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  • Embargo expired:
    17-Apr-2019 5:00 AM EDT

Article ID: 711426

Boosting Muscle Stem Cells to Treat Muscular Dystrophy and Aging Muscles

Sanford Burnham Prebys Medical Discovery Institute

Scientists from Sanford Burnham Prebys have uncovered a molecular signaling pathway involving Stat3 and Fam3a proteins that regulates how muscle stem cells decide whether to self-renew or differentiate—an insight that could lead to muscle-boosting therapeutics for muscular dystrophies or age-related muscle decline. The study was published in Nature Communications.

Released:
16-Apr-2019 12:05 PM EDT

Article ID: 711389

Rutgers Researchers Discover Crucial Link Between Brain and Gut Stem Cells

Rutgers University-New Brunswick

A gene that is necessary for prenatal growth has been shown to be essential in maintaining crucial stem cells in the adult brain and intestine, a Rutgers study has discovered.

Released:
15-Apr-2019 9:05 PM EDT
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  • Embargo expired:
    11-Apr-2019 11:00 AM EDT

Article ID: 710994

Discovery of ‘kingpin’ stem cell may help in the understanding of cancerous tumours

McMaster University

Bhatia’s team spent more than six years delving down to the cellular level to examine what they say are previously overlooked cells that form on the edges of pluripotent stem cell colonies. Having characterised these cells, the team also observed them form at the earliest stages of pluripotent cell reprogramming from adult cells. By understanding and isolating these cells on the edges using a tool called single-cell RNA sequencing gene expression analysis, the researchers discovered a subset of cells with characteristics that made them different from the cellular ecosystem surrounding them.

Released:
9-Apr-2019 10:05 AM EDT
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Article ID: 710935

New DNA “Shredder” Technique Goes Beyond CRISPR’s Scissors

Michigan Medicine - University of Michigan

The molecular "scissors" known as CRISPR-Cas9 has transformed genetic research in recent years. Now, an international team has unveiled a new CRISPR-based tool that acts more like a shredder, able to wipe out long stretches of DNA in human cells with programmable targeting. It's based on Type I CRISPR-Cas3, which has been shown to work in human cells for the first time.

Released:
8-Apr-2019 2:05 PM EDT
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Article ID: 710564

UC San Diego Health Treats 1st Cancer Patient with Stem-Cell Derived Natural Killer Cells

University of California San Diego Health

Moores Cancer Center at UC San Diego Health treats the first patient treated for cancer with a human-induced pluripotent stem cell (iPSC)-derived cell therapy called FT500. Dan Kaufman collaborated with Fate Therapeutics to bring the iPSC-derived natural killer cell cancer immunotherapy to patients.

Released:
1-Apr-2019 2:05 PM EDT
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  • Embargo expired:
    28-Mar-2019 11:00 AM EDT

Article ID: 710062

Cultured Stem Cells Reconstruct Sensory Nerve and Tissue Structure in the Nose

Tufts University

Researchers have developed a method to grow and maintain olfactory stem cells. The work is a launch pad for developing stem cell transplantation therapies or pharmacologic activation of a patient’s own dormant cells, to restore the sense of smell where it has been damaged by injury or degeneration.

Released:
21-Mar-2019 5:00 PM EDT
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Article ID: 710365

Biomedical engineers grow cardiac patches to help people recover from heart attacks

Michigan Technological University

A little goes a long way. Tiny blood vessels are essential for regenerative engineering and a team led by engineers from Michigan Tech has detailed innovative methods to ensure highly aligned, dense and mature microvasculature in engineered tissue that can be used for cardiac patches.

Released:
28-Mar-2019 10:05 AM EDT
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Article ID: 710029

How ‘Sleeper Cell’ Cancer Stem Cells Are Maintained in Chronic Myelogenous Leukemia

University of Alabama at Birmingham

While chronic myelogenous leukemia is in remission, ‘sleeper cell,’ quiescent leukemic stem cells persist in the bone marrow. Researchers find that niche-specific expression of chemokine CXCL12 by mesenchymal stromal cells controls quiescence of these treatment-resistant leukemic stem cells.

Released:
21-Mar-2019 11:05 AM EDT
  • Embargo expired:
    12-Mar-2019 11:00 AM EDT

Article ID: 708707

Targeting Stem-Like Cells Could Prevent Ovarian Cancer Recurrence

Health Sciences at the University of Pittsburgh

A new drug takes out the "seeds" that cause ovarian cancer to come back after chemo

Released:
26-Feb-2019 11:00 AM EST
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Article ID: 708964

CAR-T Cell Therapy Available at Rutgers Cancer Institute of New Jersey and Robert Wood Johnson University Hospital

Rutgers Cancer Institute of New Jersey

Those with B-cell lymphomas that do not respond to standard therapies now have another treatment option in New Jersey, as CAR-T cell therapy is now being offered at Robert Wood Johnson University Hospital New Brunswick, an RWJBarnabas Health facility, in conjunction with Rutgers Cancer Institute of New Jersey.

Released:
4-Mar-2019 8:00 AM EST

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