Products are available to quickly seal surface wounds, but rapidly stopping fatal internal bleeding has proven more difficult. Now, biomedical engineers at Texas A&M University are developing an injectable hydrogel bandage that could save lives in emergencies such as penetrating shrapnel wounds on the battlefield.
A team of Cornell University engineers and nutritionists with funding from the National Institute of Biomedical Imaging and Bioengineering, part of NIH, have designed and tested a small, portable diagnostic system that can be used in the field to test blood for vitamin A and iron deficiencies.
Bioengineers have developed micro-technologies that capture extracellular vesicles (EVs) released by brain tumors. The vesicles carry samples of the mutated genetic material and proteins causing malignancy that researchers can analyze to optimize precision cancer treatment.
Scientists at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have combined two different microscope technologies to create sharper images of rapidly moving processes inside a cell.
Chronic bladder pain affects millions with abdominal discomfort that increases as their bladder fills, causing excessive urinary urgency and frequency. Neuroscientists used optogenetics in experiments with mice to switch on and off the neurons that signal bladder pain.
Researchers are now able to use induced pluripotent stem cells (iPSC) to form a model of human adult-like cardiac muscle by introducing electric and mechanical stimulation at an early stage.
Tissue-engineering technique based on a novel cylindrical scaffolding design seeded with collagen-secreting cells yields grafts for articular cartilage repair with superior mechanical strength and durability.
Yarn weaved from carbon nanotubes monitors brain control of organ functions in rats, paves way for disease diagnosis and treatment at single nerve level.
To treat cardiovascular disease, surgery can remove blockages in large vessels in the heart or legs but is not possible in small vessels. To address this problem, researchers designed 3D-printed patches seeded with vessel-inducing endothelial cells. In a mouse model of hindlimb ischemia, the researchers identified specific patch patterns that induced growth of organized, tissue-saving blood vessels, demonstrating the potential for the novel technology to address this significant public health problem.
NIH-supported researchers at Massachusetts General Hospital are studying an alternative to current contrast agents used for magnetic resonance imaging. In a recent study, they showed that the experimental alternative, which is a manganese-based compound, performs as well as approved contrast agents. Their study appeared online Nov. 15, 2017, in Radiology.
Creating an artificial implantable kidney would be an epic advance in medicine and could address a chronic shortage of donor kidneys needed for transplant. Researchers who have been at this quest for the past 15 years face the challenge of how to keep the blood flowing smoothly through the artificial device without clotting. They are combining expertise in artificial kidney development and in computer simulation of blood flow to surmount the problem.
Clinical application of cancer fighting nanovaccines has been hampered by complications in large-scale manufacturing, quality control, and safety. Biomedical engineers developed nanovaccines that bind to the albumin protein naturally present in the body. The albumin protein then delivers these nanocomplexes to the lymph nodes, resulting in potent immune activation against multiple tumor types in mouse cancer models. The use of natural albumin as a universal vaccine shuttle is a significant step towards the application of cancer nanovaccine immunotherapy in humans.
Researchers funded by the National Institute Biomedical Imaging and Bioengineering (NIBIB), a part of the National Institutes of Health (NIH), have developed florescent nanoparticles that light up to track the progress of breast cancer metastasis. They are currently testing the particles in mice with the hope of someday being able to use them in humans.
Using an approach that combines ultrasound imaging and genetic engineering of bacterial microbes, a team from California Institute of Technology (Caltech), with funding from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), has created a powerful new system to track bacteria dispatched to deliver therapies deep inside the body.
Sutures and staples can be inadequate in complex surgeries and cannot make an air-tight or liquid-tight seal on a lung or artery wound or incision. Now researchers have created a surgical glue that sets to form an elastic air-tight or liquid-tight seal in just one minute. Successfully tested in animals, the sealant has enormous promise for life-saving use in humans.
NIH researchers have devised a biochemically formulated patch of dissolvable microneedles for the treatment of type 2 diabetes. The biochemical formula of mineralized compounds in the patch responds to blood chemistry to manage glucose automatically. In a proof-of-concept study performed with mice, the researchers showed that the chemicals interact in the bloodstream to regulate blood sugar for days at a time.
NIBIB-funded scientists have developed a new technique for 3D-printing patient-specific organ models – here the prostate gland -- using polymers that accurately model the prostate’s dimensions and physical properties, while also providing quantitative tactile feedback, or response to pressure, incisions, and suturing.
Researchers at the National Institute of Biomedical Imaging and Bioengineering have developed a synergistic cancer nanovaccine packing DNA and RNA sequences that modulate the immune response, along with anti-tumor antigens, into one small nanoparticle. The nanovaccine produced an immune response that specifically killed tumor tissue, while simultaneously inhibiting tumor-induced immune suppression to block lung tumor growth in a mouse model of metastatic colon cancer.
Hari Shroff, Ph.D., chief of the National Institute of Biomedical Imaging and Bioengineering’s lab section on High Resolution Optical Imaging (HROI), and his team have spent the last few years developing optical microscopes that produce high resolution images at very high speed. After his lab develops these new microscopes, they release the plans and software for free, so any researcher can replicate the advances made at NIH. This latest microscope builds on previous improvements that Shroff’s lab had made with selective plane illumination microscopy (SPIM).
More than 50 million Americans have food allergies and often just trace amounts of allergens can trigger life-threatening reactions. Now, researchers have developed a $40 device that fits on a key chain and can accurately test for allergens, like gluten or nuts, in a restaurant meal in less than 10 minutes.
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