Researchers from the UC San Diego, School of Medicine and colleagues have identified a new gene, ETS-1, that is linked to human congenital heart defects. The landmark study, recently published online in the journal of Human Molecular Genetics, provides important insights into some of the most prevalent forms of congenital heart defects in humans.
Over three decades, a world-recognized medical team at UC San Diego Medical Center has spurred the evolution of a complex surgery to destroy dangerous clusters of arteries and veins in the brain. Integrating innovative approaches in radiology, anesthesia, and surgery, the team has perfected a method to systematically starve these abnormal brain lesions, artery by artery, vein by vein.
A team of scientists from the UC San Diego School of Medicine and Osaka University in Japan have identified a protein switch that helps prevent liver damage, including inflammation, fibrosis and cancer. The findings suggest that a better understanding of how the protein, TAK1, works could lead to new insights into the development of liver disease and cancer.
The recent shootings at the Ft. Hood, Texas army base, allegedly by an army psychiatrist, have placed much-needed focus on mental health care in the army. In an article published in the December issue of the journal CNS Spectrum, renowned psychopharmacology expert Stephen M. Stahl, MD, PhD, calls for increased mental health staffing at Fort Hood and other army bases.
Researchers at the UC San Diego School of Medicine have pinpointed a mechanism that may help explain how chromosomal translocations – the supposedly random shuffling of large chunks of DNA that frequently lead to cancer – aren’t so random after all.
A study by neuroscientist William C. Mobley, MD, PhD, chair of the Department of Neurosciences at the UCSD, School of Medicine, and colleagues at Stanford University Medical School has demonstrated a possible new approach to slowing the inevitable progression of cognitive decline found in Down’s syndrome.
A new study finds that atherosclerosis, hardening of the arteries, was common in ancient Egyptians, challenging a belief that vascular disease is a modern affliction caused by current-day risk factors such as stress and sedentary lifestyles.
In a study that promises to improve diagnosis and monitoring of Alzheimer’s disease, scientists at the University of California, San Diego have developed a fast and accurate method for quantifying subtle, sub-regional brain volume loss using magnetic resonance imaging (MRI). The study will be published the week of November 16 in the Proceedings of the National Academy of Science (PNAS).
Igor Grant, MD, professor of psychiatry at the University of California, San Diego School of Medicine, and colleagues have been awarded a $17 million grant from the National Institute on Drug Abuse to establish the Translational Methamphetamine AIDS Research Center (TMARC) at UC San Diego.
UC San Diego Medical Center recently launched a website dedicated to offering families and the medical community valuable information about the best way to provide human milk to premature and underweight infants.
To find a long-term, permanent solution for GERD, the Center for the Future of Surgery at UC San Diego Medical Center is leading a multicenter clinical trial to test the safety and effectiveness of a new incisionless treatment.
The University of California, San Diego will lead a new Center of Expertise on Migration and Health as one of three multi-campus initiatives launched by the University of California system under the auspices of the new UC Global Health Institute.
Using imaging mass spectrometry, researchers at the University of California, San Diego have developed tools that will enable scientists to visualize how different cell populations of cells communicate. Their study shows how bacteria talk to one another – an understanding that may lead to new therapeutic discoveries for diseases ranging from cancer to diabetes and allergies.
Researchers led by Moores UCSD Cancer Center Director Dennis A. Carson, MD, professor of medicine, and Catriona Jamieson, MD, PhD, assistant professor of medicine and director of the Cancer Stem Cell Research Program at the Moores UCSD Cancer Center have been awarded $20 million over four years to develop novel drugs against leukemia stem cells.
Scientists at the University of California, San Diego School of Medicine report that regeneration of central nervous system axons can be achieved in rats even when treatment delayed is more than a year after the original spinal cord injury.
Distinguished transplant and cancer surgeon, Alan Hemming, MD, has been recruited to the University of California, School of Medicine to launch a multidisciplinary center for the treatment of advanced liver disease at the UC San Diego Medical Center and Moores UCSD Cancer Center.
Researchers at the University of California, San Diego, have identified a key protein that promotes the development of pulmonary arterial hypertension in humans and mice. This groundbreaking discovery has implications for future drug therapies that may extend the life of patients with pulmonary arterial hypertension and prevent the need for lung transplantation, currently the only cure for this debilitating disease.
Funding for two research projects at the University of California, San Diego School of Medicine are among the 76 grants announced by the Bill & Melinda Gates Foundation in the third funding round of Grand Challenges Explorations, an initiative to help scientists around the world explore bold and largely unproven ways to improve health in developing countries.
A chemical cousin of a drug currently used to treat sepsis dramatically slows the progression of amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig’s disease, in mice. The results offer a bit of good news in efforts to develop a therapy to stop or slow the progression of a disease that generally kills its victims within just a few years.
A study by researchers at the University of California, San Diego School of Medicine reports a significant breakthrough in explaining gaps in scientists’ understanding of human brain function. The study – which provides a picture of language processing in the brain with unprecedented clarity – will be published in the October 16 issue of the journal Science.
Researchers at the Moores UCSD Cancer Center have received $6 million from the National Institutes of Health to spend the next five years looking for, testing and developing chemicals called “adjuvants” that they hope will make current vaccines more effective.
More than four million babies are born in the United States every year. A growing number of these infants, more than 10 percent, are “caught” by midwives. This year, UC San Diego Medical Center celebrates the 10th anniversary of its Birth Center—California’s only in-hospital unit dedicated to natural childbirth.
The UCSD/Salk Center for Academic Research and Training in Anthropogeny (CARTA), an organized research unit of the University of California, San Diego, today announced the launch of its online Museum of Comparative Anthropogeny (MOCA), available at http://carta.anthropogeny.org/moca/about.
An international team, led by researchers from the University of California, San Diego School of Medicine and the National Eye Institute, has discovered gene variants for glaucoma in a black population. The finding could lead to future treatments or a cure for this disease, which leads to blindness in two million Americans each year.
Researchers from the University of California, San Diego School of Medicine and the Salk Institute for Biological Studies in La Jolla have developed a safe strategy for reprogramming cells to a pluripotent state without use of viral vectors or genomic insertions.
A molecular signature that helps account for the aggressive behavior of a variety of cancers such as pancreatic, breast and melanoma may also predict the likelihood of successful treatment with a particular anti-cancer drug.
UC San Diego Medical Center has once again excelled in the “Physicians of Exceptional Excellence” survey, which will appear in the October issue of San Diego Magazine. Eighty University of California, San Diego physicians in 30 specialties were rated the best doctors in the region by their peers, and more than any other health care system or medical group in San Diego County.
A study from the Center for Molecular Genetics at the University of California, San Diego School of Medicine shows that a gene called HPRT plays an important role in setting the program by which primitive or precursor cells decide to become normal nerve cells in the human brain.
A specific protein on the surface of a common bacterial pathogen allows the bacteria to leave the bloodstream and enter the brain, initiating the deadly infection known as meningitis. The new finding, which may guide development of improved vaccines to protect those most vulnerable, including young infants and the elderly, is now available online in the Journal of Experimental Medicine.
Officials of the University of California, San Diego Health Sciences and the Indian Institute of Technology (IIT) Kharagpur today signed a historic preliminary agreement to collaborate in the development of an International Medical Center (IMC) at IIT Kharagpur.
Surgeons at the University of California, San Diego Medical Center have performed the next in a series of groundbreaking single-incision surgeries. Through one small port in the navel, surgeons removed a kidney and ureter and reconstructed a patient’s bladder as part of an innovative cancer surgery.
An international group of researchers is the first to show that common variations in a gene – previously shown to be associated with Retts Syndrome, autism, and mental retardation – are associated with differences in brain structure in both healthy individuals and patients with neurological and psychiatric disorders.
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, have discovered a connection between mutations in the INPP5E gene and ciliopathies. Their findings, which may lead to new therapies for these diseases, will appear in the online edition of Nature Genetics on August 9.
Researchers at the Shiley-Marcos Alzheimer's Disease Research Center at the University of California San Diego are about to launch a Phase 2 clinical trial to test a gene therapy treatment for Alzheimer's disease (AD) called CERE-110. Previously, CERE-110 was carefully studied in animals as well as in a small study to assess safety in humans.
An international team of scientists and clinicians from the United States and Saudi Arabia are working to develop gene therapy for treating a rare, hereditary retinal disease. The therapy has been shown to restore lost vision in animal models of retinitis pigmentosa (RP). Their work is being funded in part by a $1.5 million grant from the Prince Salman Center for Disability Research in Saudi Arabia, where the recessive gene mutation that leads to the eye disease RP has been found in children from several families.
New imaging technology provides insight into abnormalities in the brain circuitry of patients with anorexia nervosa (commonly known as anorexia) that may contribute to the puzzling symptoms found in people with the eating disorder.
Group B Streptococcus (GBS), a bacterial pathogen that causes sepsis and meningitis in newborn infants, is able to shut down immune cell function in order to promote its own survival, according to researchers at the University of California, San Diego School of Medicine and the Skaggs School of Pharmacy and Pharmaceutical Sciences. Their study, published online July 13 in the Journal of Experimental Medicine, offers insight into GBS infection.
Veterans with post-traumatic stress disorder (PTSD) are more likely to have metabolic syndrome than veterans without PTSD, according to a study led by Pia Heppner, Ph.D., psychologist with the University of California, San Diego School of Medicine and Veterans Affairs of San Diego, VA Center of Excellence for Stress and Mental Health (CESAMH).
The University of California, San Diego Medical Center is the first hospital in California to enroll patients in a multi-center clinical trial, sponsored by Angioblast Systems Inc., to examine the safety and feasibility of administering adult stems cells to treat congestive heart failure.
The volunteers and patients of the UC San Diego Student-Run Free Clinic Project celebrated some early holiday cheer thanks to a generous gift from the Clark CARES Foundation, which presented the Free Clinic with a $15,000 contribution.
San Diego State University (SDSU) and the Moores Cancer Center at the University of California, San Diego (UC San Diego) are joining forces to help explain and eliminate cancer disparities. The five-year combined $15 million grant from the National Cancer Institute (NCI) of the National Institutes of Health will fund research, education and community outreach programs in the San Diego region.
A secondary analysis of a large, multicenter clinical trial has shown that a diet loaded with fruits, vegetables and fiber and somewhat lower in fat compared to standard federal dietary recommendations cuts the risk of recurrence in a subgroup of early-stage breast cancer survivors "“ women who didn't have hot flashes "“ by approximately 31 percent.
Rather than testing for individual marker genes or proteins, researchers at UC San Diego and the Moores UCSD Cancer Center have evidence that groups, or networks, of interactive genes may be more reliable in determining the likelihood that a form of leukemia is fast-moving or slow-growing.
The University of California, San Diego's Stein Institute for Research on Aging "“ which celebrates its 25th Anniversary this year "“ focuses on "healthy aging." As some say, 70 is now "the new 50" "“ and the coming New Year is a great time to take steps to remain cognitively and emotionally healthy.
Continuous positive airway pressure (CPAP) treatment seems to improve cognitive functioning in patients with Alzheimer's disease who also suffer from obstructive sleep apnea, according to the results of a randomized clinical trial conducted at the University of California, San Diego.
Researchers at the University of California, San Diego (UCSD) and the Moores UCSD Cancer Center have discovered what could be a novel drug target for an often difficult-to-treat form of leukemia. The investigators have identified a unique "signature" or pattern of a specific family of enzymes in patients with chronic lymphocytic leukemia (CLL), the most common form of adult leukemia.
University of California, San Diego Health Sciences leaders have announced that they have executed a formal Memorandum of Understanding (MOU) with Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD), with the objective of developing future collaborations in biomedical research and education to advance human health.
Researchers at the University of California, San Diego School of Medicine, led by Ajit Varki, M.D., have shown a new mechanism for how human consumption of red meat and milk products could contribute to the increased risk of cancerous tumors.
Erik Viirre, M.D., Ph.D., a UCSD School of Medicine physician who specializes in diseases of the inner ear, recently completed his fifth weightless flight with Zero Gravity Corporation. Aboard the same plane were four paraplegic children who left their wheelchairs on earth as they floated free in a zero-gravity environment.
Scientists have thought that one way to foil a tumor from generating blood vessels to feed its growth "“ a process called angiogenesis "“ was by creating drugs aimed at stopping a key vessel growth-promoting protein. But now the opposite seems to be true.
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