St. Jude Children’s Research Hospital plays key role in research showing that drug shortages erode the quality and increase the cost of cancer care; experts warn that shortages persist despite efforts to fix the problem.
St. Jude Children’s Research Hospital-led study links inherited variations in a few genes to a substantially increased risk of acute lymphoblastic leukemia and helps to explain ethnic differences in the cancer’s incidence.
The United States Patent and Trademark Office today awarded St. Jude Children’s Research Hospital U.S. patent number 8,399,645 for St. Jude’s invention of compositions for genetically modifying human immune cells so they can destroy some of the most common forms of cancer in children and adults.
The Helping Hands initiative at St. Jude Children’s Research Hospital provides breaks to caregivers, underscoring the hospital’s commitment to family-centered care and serves as model program to other institutions.
A study led by St. Jude Children’s Research Hospital has discovered mutations in two genes that lead to the death of nerve cells in amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, and related degenerative diseases.
Even though costs for medications will continue to rise in 2013 by as much as 4 percent, the increase is projected to be less than in previous years, according to a report in the advance online publication of the American Journal of Health-System Pharmacy, the journal of the American Society of Health-System Pharmacists (ASHP).
St. Jude Children’s Research Hospital investigators found evidence that chest irradiation may leave some adult survivors of childhood cancer in danger of developing pulmonary hypertension in middle age.
St. Jude Children’s Research Hospital has been named one of the best cancer care hospitals in the country by Parents magazine.
Genome sequencing data once regarded as junk is now being used to gain important clues to help understand disease. The latest example comes from the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project, where scientists have developed an approach to mine the repetitive segments of DNA at the ends of chromosomes for insights into cancer.
Research led by St. Jude Children’s Research Hospital scientists has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment outcomes.
national drug shortage has been linked to a higher rate of relapse among children, teenagers and young adults with Hodgkin lymphoma enrolled in a national clinical trial, according to research led by St. Jude Children’s Research Hospital.
Research led by the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project has identified a fusion gene responsible for almost 30 percent of a rare subtype of childhood leukemia with an extremely poor prognosis.
Among thousands of entries, Nikon has awarded its top honor to Jennifer Peters, Ph.D., and Michael Taylor, Ph.D., of St. Jude Children’s Research Hospital for their photomicrograph, “The blood-brain barrier of a live zebrafish embryo.” It is believed to be the first image showing the formation of the blood-brain barrier in a live animal.
St. Jude Children’s Research Hospital will host a webcast about the late effects of childhood cancer and its treatment Saturday, October 27, at 9 a.m. CST.
At St. Jude Children’s Research Hospital, patients use beads to mark treatment milestones, from losing their hair to completing chemotherapy, in a program other hospitals could tailor to meet the needs of their patients.
Early treatment response is a powerful predictor of long-term outcome for young patients with acute myeloid leukemia (AML). The information can help physicians decide whether a more intensive approach is needed. Research led by St. Jude Children’s Research Hospital investigators has identified the best test for measuring that response and guiding therapy.
September spotlights childhood cancer, which remains the leading cause of death by disease of young Americans. At St. Jude Children’s Research Hospital, doctors and scientists are working to change that statistic.
St. Jude Children’s Research Hospital reports success using a targeted educational approach to teach young sickle cell disease patients to remain motionless during MRI scans, making the process safer.
Scientists have identified new genetic alterations underlying a high-risk subtype of the most common childhood cancer that could be effectively targeted with existing leukemia therapies.
A faulty gene linked to a rare blood vessel disorder has led investigators to discover a mechanism involved in determining the fate of possibly thousands of proteins working inside cells.
St. Jude Children’s Research Hospital study shows how compounds blocking an enzyme universal to all influenza viruses may allow development of new antiviral drugs that also avoid the problem of drug resistance.
Studies led by St. Jude Children’s Research Hospital show that a protein working on the frontlines of the immune response dampens inflammation and might offer a completely new approach to fighting bacterial infections.
A trial led by St. Jude Children’s Research Hospital investigators succeeds in keeping cure rates high for young patients with favorable-risk Hodgkin lymphoma while reducing their chances of serious treatment side effects.
The St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project lifts lid on the most aggressive subtype of medulloblastoma and finds genes that cooperate in tumor development.
The St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project today announced the largest-ever release of comprehensive human cancer genome data for free access by the global scientific community.
A new analysis from St. Jude Children’s Research Hospital adds to evidence that equal access to comprehensive treatment and supportive care typically translates into equally good outcomes for most young African-American and white cancer patients.
Research led by St. Jude Children’s Research Hospital investigators suggests that safeguarding cell survival and maintaining a balanced immune system is just the start of the myeloid cell leukemia sequence 1 (MCL1) protein’s work.
St. Jude Children’s Research Hospital scientists have rewritten the job description of the protein TopBP1 after demonstrating that it guards early brain cells from DNA damage. Such damage might foreshadow later problems, including cancer.
An international study found that bone marrow transplants are not the best option for some young patients with acute lymphoblastic leukemia (ALL) who fail to attain clinical remission after the initial weeks of intense chemotherapy known as induction therapy.
Ching-Hon Pui, M.D., a renowned leader in the research and treatment of childhood leukemia, is the recipient of the 2012 Pediatric Oncology Award from the American Society of Clinical Oncology (ASCO). The honor recognizes Pui’s many contributions to better understanding the blood cancer’s biology and treatment as well as his role in improving leukemia survival rates.
St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project and Memorial Sloan-Kettering Cancer Center discover first gene alteration associated with patient age and neuroblastoma outcome.
More than 70 years after the first sulfa drugs helped to revolutionize medical care and save millions of lives, St. Jude Children’s Research Hospital scientists have determined at an atomic level the mechanism these medications use to kill bacteria. The discovery provides the basis for a new generation of antibiotics that would likely be harder for bacteria to resist and cause fewer side effects.
Results from a St. Jude Children’s Research Hospital and the Children’s Oncology Group study pinpoint genetic basis for increased leukemia risk facing Hispanic children and provide new hope for closing survival gap.
Researchers studying a rare, lethal childhood tumor of the brainstem discovered that nearly 80 percent of the tumors have mutations in genes not previously tied to cancer.
St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project findings help solve mystery of retinoblastoma’s rapid growth in work that also yields a new treatment target and possible therapy.
Researchers have discovered that a subtype of leukemia characterized by a poor prognosis is fueled by mutations in pathways distinctly different from a seemingly similar leukemia associated with a much better outcome.
St. Jude Children’s Research Hospital has launched a freely available website for published research results from the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project (PCGP). The PCGP is the largest effort to date aimed at sequencing the entire genomes of both normal and cancer cells from pediatric cancer patients, comparing differences in the DNA to identify genetic mistakes that lead to childhood cancers.
Symptoms improved significantly in adults with the bleeding disorder hemophilia B following a single treatment with gene therapy developed by researchers at St. Jude Children’s Research Hospital in Memphis and demonstrated to be safe in a clinical trial conducted at the University College London (UCL) in the U.K.
St. Jude Children’s Research Hospital scientists show that a gene essential for normal development of the lymphatic system also plays a critical role in forming the valves that help maintain the body’s normal fluid balance.
St. Jude Children’s Research Hospital scientists discover that a post-production addition to most proteins can serve as a key to mediate protein interactions, which are at the foundation of life.
Nearly a decade after St. Jude Children’s Research Hospital began offering therapeutic scrapbooking as an alternative to traditional support groups for patients’ parents, researchers have demonstrated that the sessions promote hopefulness, in part by helping families recognize their strengths and by expanding their support network. The study on the effects of therapeutic scrapbooking were published in the Journal of Psychosocial Oncology.
A small molecule developed at St. Jude Children’s Research Hospital advances progress toward more tailored drugs in research that also offers insight into the biology of thyroid hormone.
Recently approved drug for treatment of an adult cancer is the latest example of how St. Jude scientific discoveries are used to identify new therapies that benefit patients regardless of age.
St. Jude Children’s Research Hospital scientists tie low levels of a key DNA repair protein to loss of regulatory genes in a study that offers new clues about why acute lymphoblastic leukemia sometimes returns.
The largest study ever of a rare childhood brain tumor found more than half the tumors carried extra copies of specific genes linked to cancer growth, according to research led by St. Jude Children’s Research Hospital investigators.
Research led by St. Jude Children’s Research Hospital investigators used a pioneering approach to drug development and identified dozens of potential new treatments of ependymoma, a rare tumor of the brain and spinal cord.
St. Jude Children’s Research Hospital recognizes Childhood Cancer Awareness Month.
St. Jude Children’s Research Hospital officials have named Richard Gilbertson, M.D., Ph.D., director of its Comprehensive Cancer Center and an executive vice president in the organization.
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