Oral chemotherapy drugs are so expensive that they will be out of the financial reach of most Medicare patients even when the Part D doughnut hole closes in 2020, according to new study from the University of North Carolina at Chapel Hill.
An Internet-based system for symptom collection benefited patients while giving them a clearer voice in their own care.
Women with a history of a false-positive mammogram result may be at increased risk of developing breast cancer for up to 10 years after the false-positive result, according to a study led by a researcher with the University of North Carolina Lineberger Comprehensive Cancer Center.
UNC Lineberger researchers say the findings of a new study indicate that activity trackers could be a useful tool for tracking symptoms and physical function
Schizophrenia is notoriously difficult to diagnose and treat, in large part because it manifests differently in different people. A new study helps explain why. Researchers at UNC have created a map that shows how specific schizophrenia symptoms are linked to distinct brain circuits.
University of North Carolina School of Medicine collaborators uncovered an epigenetic mechanism that could be the cause of painful chronic ear infections that plague people with chromosomal and genetic conditions.
Imagine you have a bone injury but you heal slowly. Instead of forming bone, you could form fat. UNC researchers may have found a way to tip the scale in favor of bone. They used cytochalasin D, a naturally occurring substance, to alter gene expression in stem cells to force them to become bone.
A UNC Lineberger Comprehensive Cancer Center-led study published in the Journal of Clinical Oncology identified a group of women with HER-2 positive breast cancer who could benefit from less intensive targeted treatment.
Scientists at the University of North Carolina and UC-San Francisco created a general tool to probe the activity of orphan receptors, illuminating their roles in behavior and making them accessible for drug discovery for the first time.
An evaluation of a statewide shaken baby prevention effort found that the number of calls to a nurse advice line from North Carolina parents who called because of a crying baby were reduced in the first 2 years after the intervention was implemented in 2007. However, the study did not find a statistically significant reduction in the number of abusive head trauma (AHT) or “shaken baby” cases in North Carolina during the same period.
A study led by a UNC Lineberger Comprehensive Cancer Center researcher found that lower doses of chemotherapy and radiation produced complete pathologic responses in 86 percent of a group of HPV-positive patients.
A study published in the New England Journal of Medicine found that vitamin D and calcium supplements do not reduce the risk of colorectal adenomas, which are benign tumors that can evolve into colorectal cancer.
“Organs-on-a-chip” have become vital for biomedical research, as researchers seek alternatives to animal models for drug discovery and testing. The new grant will fund a technology that represents a major step forward for the field, overcoming limitations that have mired other efforts.
The Cancer Genome Atlas Network of researchers analyzed hundreds of breast cancer samples to reveal genetic drivers of invasive lobular carcinoma, the second most commonly diagnosed invasive form of breast cancer.
A new analysis led by researchers at the UNC School of Medicine identified “illogical thoughts” as most predictive of schizophrenia risk. Surprisingly, perceptual disturbances – the forerunners of hallucinations – are not predictive.
Researchers at the UNC School of Medicine found that people with anorexia nervosa have very different microbial communities inside their guts compared to healthy individuals and that this bacterial imbalance is associated with some of the psychological symptoms related to the eating disorder.
A UNC Lineberger Comprehensive Cancer Center researcher and his partners describe the design and engineering of the new bioluminescent imaging tool called the “LumiFluor” in a study published in the journal Cancer Research.
A UNC Lineberger Comprehensive Cancer Center researcher is a co-investigator with Sunnyvale, Calif.,-based InSilixa Inc. for the development of a rapid oral HPV test.
A new study led by researchers in the UNC Department of Pediatrics finds a direct correlation between more severe forms of obesity in children and related risk factors for developing heart disease and diabetes—particularly in boys.
If you have two faulty copies of the CFTR gene, you will have cystic fibrosis. But the severity of your disease will depend partly on many other genes. Now, researchers report that five regions of the human genome are home to the genetic variations that play major roles in disease severity.
A new study has shown that for certain cancer drugs, participants in clinical trials are often not representative of the patients that ultimately take the drugs, raising questions about the direct applicability of trial data.
The UNC Lineberger Comprehensive Cancer Center’s application for renewal of a major five-year, federal grant earned an "exceptional" rating from the National Cancer Institute. The rating is the highest that a cancer center can earn for the application.
Inside our bones there is fat. Diabetes increases the amount of this marrow fat. And now a study from the UNC School of Medicine shows how some diabetes drugs substantially increase bone fat and thus the risk of bone fractures.
The study, published in Nature Genetics, paves the way for potential personalized medicine approaches for the deadly cancer type.
Metformin was introduced as a type-2 diabetes treatment decades ago, but researchers still debate how the drug works. A new study shows that metformin’s primary effect occurs in the gut, not the bloodstream. And a new version of the drug could help more people control their diabetes.
James Bear, PhD, uncovers the intricate mechanisms that allow certain cells to move, discoveries with implications for cancer metastasis.
In an article published in JAMA Oncology, a study led by a UNC Lineberger Comprehensive Cancer Center researcher and colleagues shows that a system they developed accurately and reliably captures the patient experience with cancer drug side effects.
Charlotte charity Taylor’s Tale helped inspire a law designed to stimulate the creation of new treatments for rare diseases and spur economic development in North Carolina. House Bill 823, signed into law by Governor McCrory on August 6, will establish an Advisory Council on Rare Diseases within the School of Medicine of the University of North Carolina at Chapel Hill (UNC).
Last December, researchers identified more than 1,000 gene mutations in individuals with autism, but how these mutations increased risk for autism was unclear. Now, UNC researchers are the first to show how one of these mutations disables a molecular switch in one of these genes to cause autism.
Scientists at the UNC School of Medicine and the UNC Lineberger Comprehensive Cancer Center found that a rare type of stem cell is immune to radiation damage thanks to high levels of a gene called Sox9.
The Histone Antibody Specificity Database (www.histoneantibodies.com), is a newly launched online portal that lets scientists find the right antibodies for their research with a much higher degree of confidence than ever before.
A new review article, published in the July 23, 2015 issue of The New England Journal of Medicine, analyzes the pros and cons of five different interventional approaches to gallbladder disease.
College women who are more emotionally invested in Facebook and have lots of Facebook friends are less concerned with body size and shape and less likely to engage in risky dieting behaviors. But that’s only if they aren’t using Facebook to compare their bodies to their friends’ bodies, according to the authors of a surprising new study at the University of North Carolina School of Medicine.
Researchers at the UNC School of Medicine created a first-of-its-kind animal model to pinpoint two biomarkers that are elevated in the most severe form of coronary disease.
In a study published in Nature Medicine, UNC Lineberger Comprehensive Cancer Center researchers report their findings of just how a certain tumor-suppressing protein helps prevent colon cancer. With this discovery, researchers believe they’ve found a possible drug target for colon cancer patients who lack the tumor suppressor.
A panel of experts has developed recommendations for developing patient-focused assessments of health care performance. Their findings were published in the journal Value in Health.
University of North Carolina (UNC) School of Medicine researchers have developed an innovative, experimental gene transfer-based treatment for children with giant axonal neuropathy (GAN).
In a new pre-clinical study, UNC Lineberger researchers show that they can exploit cancer’s reliance on a particular protein to help fight triple negative breast cancer. They believe the protein could be a potential new drug target.
Researchers at the University of North Carolina and NC State have created the first “smart insulin patch” that can detect increases in blood sugar levels and secrete doses of insulin into the bloodstream whenever needed.
A study by The Cancer Genome Atlas network of researchers refined and revealed molecular sub-groups of patients with cutaneous melanoma who could potentially benefit from targeted treatments based on their tumor genetics, and helped clarify the immune system’s role in the disease.
Scientists from the UNC School of Medicine provide the first direct experimental evidence for how primordial proteins developed the ability to accelerate the central chemical reaction necessary to synthesize proteins and thus allow life to arise not long after Earth was created.
New research shows that the close linkage between the physical properties of amino acids, the genetic code, and protein folding was likely the key factor in the evolution from building blocks to organisms when Earth’s first life was emerging from the primordial soup.
A University of North Carolina at Chapel Hill analysis published in the journal Tobacco Control synthesized the results of 37 different experiments comparing picture-based and text warnings, finding that picture-based warnings were more effective than text warnings on 20 of 25 different outcome measures.
A new University of North Carolina School of Medicine study shows that using the most common form of electric brain stimulation had a statistically significant detrimental effect on IQ scores.
When common chemotherapy drugs damage DNA in cancer cells, the cells can’t replicate. But the cells have ways to repair the DNA. The cancer drugs aren’t effective enough. UNC researchers developed a way to find where this DNA repair happens. Their goal is to increase the potency of cancer drugs.
A new treatment for melanoma could be on the horizon, thanks to a finding by a UNC Lineberger Comprehensive Cancer Center-led team. In the study, which was published in the journal Clinical Cancer Research, the authors report that they found high levels of an enzyme in melanoma samples that they believe is a potential drug target.
Researchers have perfected a noninvasive “chemogenetic” technique that allows them to switch off a specific behavior in mice – such as voracious eating – and then switch it back on. The method works by targeting two different cell surface receptors. It’s the first fruit of the NIH BRAIN Initiative.
New research led by Brigham and Women’s Hospital in collaboration with the UNC Lineberger Comprehensive Cancer Center finds that breast-conserving therapy – or the removal of less breast tissue via a lumpectomy – was successful in more than 90 percent of the women who became eligible for this procedure after treatment with chemotherapy. Despite these findings, more than 30 percent who were eligible for breast conserving therapy chose to have the entire breast removed via mastectomy.
A new study by University of North Carolina at Chapel Hill researchers has found dramatic improvements in the care of patients with cirrhosis and liver failure and recommends improved treatment strategies for patients with cirrhosis and concurrent bacterial infections.
In February, UNC neurologist Hae Won Shin, MD, and neurosurgeon Eldad Hadar, MD, were the first in the state to implant the NeuroPace RNS System following the medical device’s recent FDA approval. In clinical trials, the NeuroPace system greatly reduced the number of seizures experienced by patients with severe epilepsy.
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