• share
• favorite_border

The p53 gene has been a well-documented player in the prevention of tumors and is considered the most frequently mutated gene in human tumors. These mutations often can be caused by disruption in normal p53 function. A team of investigators, including those from New Jersey’s only National Cancer Institute-designated Comprehensive Cancer Center, has identified a mechanism that interrupts normal p53 function, thus causing negative impact which can lead to tumor development.

• share
• favorite_border

If you were found to be a carrier of a mutated form of the tumor suppressor genes known as BRCA1 and BRCA2, would you share that information with your child? While parents don’t always choose to share these test results with their offspring, they may choose to discuss related health information with their child. That is the result of a study by a team of investigators from The Cancer Institute of New Jersey and Fox Chase Cancer Center, whose findings suggest parents are using their mutation status as an opportunity to further educate their children on cancer risk reduction.

• share
• favorite_border

As Memorial Day Weekend and the start of summer beach season fast approach, New Jersey’s only NCI-Comprehensive Cancer Center is making experts available to discuss the risks of developing skin cancer and what steps can be taken to prevent it.

• share
• favorite_border

In an effort to improve current anticancer treatments, investigators at New Jersey’s only NCI-Comprehensive Cancer Center have been targeting a process known as autophagy, in which cancer cells eat themselves as a measure of self preservation under stress. While preclinical studies have shown that inhibition of autophagy sensitizes tumor cells to treatment, researchers recently have had an opportunity to observe these effects in early-stage clinical trials involving a drug commonly used to treat malaria.

• share
• favorite_border

Studies have well established that women who harbor a mutation in the BRCA1 tumor suppressor gene are at greater risk for developing breast and ovarian cancers. Less known is information on other molecular events that may impact cancer formation in cells having a BRCA1 mutation. Investigators from New Jersey’s only NCI-Comprehensive Cancer Center and a number of major cancer centers in Europe have identified the role a key protein plays in helping cells with mutant BRCA1 genes to survive.

• share
• favorite_border

Nurses from New Jersey’s only NCI-Comprehensive Cancer Center have developed a multimedia education tool for reducing the amount of anxiety they experience when performing high-risk procedures that are infrequently performed. The focus of the work is the creation of audiovisual materials concerning care for patients with a hepatic arterial infusion (HAI) pump.

• share
• favorite_border

Women who survive early-stage breast cancer and smoke have an increased chance of developing a new second cancer in their other breast or elsewhere. Investigators from New Jersey’s only NCI-Comprehensive Cancer Center say the findings, being presented at the Annual Meeting of the American Radium Society, show that women can exercise some control over a known risk factor for developing a new second cancer.

• share
• favorite_border

Usually when all else fails with a technical device, a “reset” button can be pressed, preventing a glitch from going any further. What if that could be done with threats to a person’s health? Investigators from New Jersey’s only NCI-Comprehensive Cancer Center and colleagues have discovered that a form of a dietary trace element can help reset a cell’s “biological clock” when it is disrupted by a chemical carcinogen. The findings ultimately may help prevent the development of breast cancer.

• share
• favorite_border

Building off recent laboratory discoveries on how cancer cells become resistant to cancer-starving therapies, scientists at New Jersey’s only NCI-Comprehensive Cancer Center are applying that knowledge to a process in which cancer cells eat themselves to downsize and resist therapy. The ultimate goal of a new clinical trial is to improve upon current anticancer treatments with combination therapy.

• share
• favorite_border

Trying to break down a barrier that prevents effective treatment of prostate cancer, investigators from New Jersey’s only NCI-Comprehensive Cancer Center have identified candidate drugs that block a key protein responsible for tumor growth. Researchers hope their laboratory work with zebrafish will pave the way for clinical trials.

• share
• favorite_border

Investigators from New Jersey’s only NCI-Comprehensive Cancer Center are sharing their findings on how a common genetic variation can impact diagnosis of breast cancer in postmenopausal women. At focus is a tumor suppressor gene and how a genetic change in DNA sequence can delay disease onset for this population.

• share
• favorite_border

Among people over 50, those who did not finish high school or have not recently had a mammogram, PSA test or colorectal cancer screening, are also less likely to be screened for skin cancer. The finding, in a study by an investigator at New Jersey’s only NCI-Comprehensive Cancer Center and colleagues, shows that physicians may want to further emphasize skin examinations for this population.

• share
• favorite_border

Does lactate play a role in the metabolic fate of cancer cells? Researchers from New Jersey’s only NCI-Comprehensive Cancer Center are in Washington, D.C., this week for the 101st Annual Meeting of the American Association for Cancer Research to share their findings on what role this common energy byproduct in the body plays in the development of breast cancer cells and surrounding connective tissue.

• share
• favorite_border

While the reasons for the unequal cancer burden among different minority groups may not be fully known, factors are believed to include inferior health insurance and greater poverty than the general population, which could result in delayed doctor visits and diagnosis in disease. Experts from New Jersey’s only NCI-Comprehensive Cancer Center are available for comment on risk factors, treatment and prevention options for the various types of cancer that are more prevalent in these groups.

• share
• favorite_border

New Jersey’s only NCI-Comprehensive Cancer Center is joining communities, schools and other institutions across the nation in celebrating the contributions of their libraries and librarians during this year’s National Library Week (April 11 – 17). The unique library at The Cancer Institute of New Jersey is known as the Resource and Learning Center and provides valuable educational resources to both cancer patients and the public.

• share
• favorite_border

Scientists, oncology healthcare professionals and others are meeting this week to share ideas about the development of new treatments for cancer, which result from extensive research and drug development. Scientific leaders from New Jersey’s only NCI-Comprehensive Cancer Center are leading a key discussion on the topic of cell self-digestion and how the latest discoveries in this area can relate to new therapies.

• share
• favorite_border

Research by an investigator at New Jersey’s only NCI-Comprehensive Cancer Center and colleagues shows that the type of specialist men with localized prostate cancer see can influence the therapy they receive. Patients aged 65 to 69 who consult a urologist are more likely to undergo surgery to remove the prostate, while those who see a radiation oncologist and a urologist, regardless of age, usually receive radiation therapy.

• share
• favorite_border

The frequency of post-operative complications following surgery for liver cancer is associated with a hospital having a low volume of liver surgery. That finding by investigators at New Jersey’s only NCI-Comprehensive Cancer Center is being presented this week at the 63rd Annual Society of Surgical Oncology Symposium.

• share
• favorite_border

While new cases of colorectal cancer continue to decline in the United States, it remains the third leading cause of cancer death in the nation. That is why researchers at New Jersey’s only NCI-Comprehensive Cancer Center are looking to add a drug known for fighting malaria to traditional chemotherapy for colorectal cancer to see if treatment can be made more effective for patients.

• share
• favorite_border

Enhancing its strong presence as a statewide leader in cancer care and providing patients with additional access to cancer programs, The Cancer Institute of New Jersey Network of hospitals has formally welcomed Cooper University Hospital as its newest Major Clinical Research Affiliate.

• share
• favorite_border

Expanding its research horizons in the fight against cancer, New Jersey’s only NCI-Comprehensive Cancer Center has formally welcomed Princeton University as a scientific collaborator. The new relationship will allow for the sharing of resources and the strengthening of quality research programs at both institutions.

• share
• favorite_border

Investigators at New Jersey’s only NCI-designated Comprehensive Cancer Center have launched a clinical trial targeting immunotherapy. Scientists are testing a series of vaccine injections, including those given directly into the tumor, to see if they will produce an immune response against pancreatic cancer.

• share
• favorite_border

In an effort to build the groundwork for future research on health promotion among colorectal cancer patients, investigators at New Jersey’s only NCI-Comprehensive Cancer Center have launched a study examining diet and physical activity patterns in those patients who have recently finished treatment. The goal is to promote positive health behavior changes in this population.

• share
• favorite_border

Research by an investigator at New Jersey’s only NCI-Comprehensive Cancer Center shows the benefits of a shortened radiation course to those with the most common type of non-invasive breast cancer, ductal carcinoma in situ. The results are being presented as part of the 32nd Annual CTRC-AACR San Antonio Breast Cancer Symposium.

• share
• favorite_border

Researchers from New Jersey’s only NCI-Comprehensive Cancer Center are presenting findings on advances in the area of breast cancer and patient data collection at the Annual American Society for Radiation Oncology meeting this week. The benefits of implanting gold markers in the breast cavity to deliver radiation and the testing of a prototype web-based system to improve radiation oncology practice are among the presentations.

• share
• favorite_border

In trying to better predict a patient’s response to chemotherapy for cancer treatment, investigators at New Jersey’s only NCI-Comprehensive Cancer Center and Rutgers University, have identified a way to better manipulate a gene product to cause cancer cells to die. And in order to further examine this mechanism, researchers also created a new vehicle for pre-clinical testing of cancer treatments.

• share
• favorite_border

New research suggests that more intervention is needed to ensure cancer survivors are having screening and surveillance needs met as they transition from cancer treatment back to primary care. Investigators at New Jersey’s only NCI-Comprehensive Cancer Center who conducted the study say since the cancer survivor population continues to grow, these latest findings are key.

• share
• favorite_border

An epidemiologist at New Jersey’s only NCI-Comprehensive Cancer Center has been awarded a grant from the National Institutes of Health to explore the clinical outcomes of prostate cancer in older men. The two-year study will focus on this population following the two most commonly used treatment options: deferred treatment and radiation therapy.

• share
• favorite_border

An associate director at New Jersey’s only NCI-Comprehensive Cancer Center has been awarded a $1 million Challenge Grant to study the role of cell metabolism in cancer growth. The research involving The Cancer Institute of New Jersey, Rutgers and Princeton Universities, aims to shed light on why some cancer treatments fail.

• share
• favorite_border

A $1.6M award from the Department of Defense will help fund the participation of New Jersey’s only NCI Comprehensive Cancer Center in the development of a prostate cancer consortium. The effort, which involves 14 cancer centers, will help expand clinical trial options for prostate cancer patients in New Jersey and elsewhere.

• share
• favorite_border

Keeping with its mission of offering comprehensive services to patients, New Jersey’s only NCI Comprehensive Cancer Center has expanded its Urologic Oncology Program, having gained formal recognition as a Section of Urologic Oncology. The program provides highly specialized care for patients with prostate, testicular, kidney, and bladder cancers.

• share
• favorite_border

Grabbing your morning "cup of joe" just may help save someone's life. That sentiment comes from New Jersey's only NCI Comprehensive Cancer Center, as it once again is the recipient of proceeds from the sale of the "pink ribbon bagel" by local Panera Bread cafes. The effort is part of a nationwide campaign during Breast Cancer Awareness Month.

• share
• favorite_border

Rutgers University and collaborators have been awarded funds through the NIH and the American Recovery and Reinvestment Act to develop tools to further target how prostate cancer is identified. The team, which includes an investigator from New Jersey’s only Comprehensive Cancer Center, will target its efforts at improving current clinical methods through enhanced use of MRI.

• share
• favorite_border

Researchers at New Jersey’s only NCI-Comprehensive Cancer Center have shown that men diagnosed with localized prostate cancer beginning in the early 1990’s had significantly improved survival outcomes compared with patients whose cancers were diagnosed prior to that time. The study found that a patient’s risk of dying from prostate cancer over a ten-year period following diagnosis declined by more than 60 percent compared with patients diagnosed in the 1970s and 1980s.

• share
• favorite_border

October marks National Breast Cancer Awareness Month, and investigators at New Jersey’s only NCI-Comprehensive Cancer Center are engaging in unique research examining DNA to find out why some women develop breast cancer earlier than others. Experts can discuss that topic and other areas including the latest in radiation treatment, the unique needs of young women with breast cancer, and the benefits of breast self exams.

• share
• favorite_border

The various forms of gynecologic cancer will result in more than 80,000 new cases nationwide this year. Experts from New Jersey's only NCI-Comprehensive Cancer Center are available to discuss the latest in research, treatment and prevention surrounding this group of diseases.

• share
• favorite_border

New research published in the Journal of the National Cancer Institute by a team of investigators at New Jersey’s only NCI-Comprehensive Cancer Center, shows significant changes in the profile of prostate cancer patients since the late 1980s. Among the findings are patients were diagnosed at a younger age and had earlier stage prostate cancer than those diagnosed in previous years.

• share
• favorite_border

Prostate cancer will strike one in six men and it is the most frequently diagnosed cancer in men. Experts at New Jersey’s only NCI-designated Comprehensive Cancer Center can discuss the latest in prostate cancer prevention, treatment and research, including the importance of being screened early and the benefits of robotic surgery.

• share
• favorite_border

While rare, pediatric cancer is the leading cause of death by disease in children younger than 15, and it is a population that has very unique needs. Experts at New Jersey’s only NCI-designated Comprehensive Cancer Center can discuss those needs, including classroom education and concerns about late effects.

• share
• favorite_border

Researchers at New Jersey’s only NCI Comprehensive Cancer Center have launched a clinical trial that focuses on a shorter course of radiation treatment for those with early-stage breast cancer. The accelerated treatment over a reduced time cuts the average treatment time by nearly half, which could improve a patient’s quality of life.

• share
• favorite_border

New Jersey’s only NCI-designated Comprehensive Cancer Center has been awarded $5.1 million in competitive grants by the New Jersey Commission on Cancer Research. The awards are designed to strengthen cancer research infrastructure in the state through shared resources and other means.

• share
• favorite_border

A cancer control and prevention expert at New Jersey’s only NCI-designated Comprehensive Cancer Center outlines benefits of increased physical activity for lung cancer patients in the latest edition of Physician’s Weekly. Overall better mood, more vigor, and fewer problems with shortness of breath are among the benefits described in the commentary.

• share
• favorite_border

Researchers at New Jersey's only NCI-Comprehensive Cancer Center have opened a clinical trial to evaluate whether the standard treatment for a common form of kidney cancer works better by itself or when combined with a certain type of blood cell that comes from a patient's relative.

• share
• favorite_border

Enhancing its strong presence as a statewide leader in cancer care and providing patients with additional access to cancer programs, The Cancer Institute of New Jersey Network of hospitals has formally welcomed Mountainside Hospital as its newest Clinical Research Affiliate.

• share
• favorite_border

What if the quality of cancer care could be assessed and improved in "real time" instead of waiting the typical two years for clinical data to be analyzed and changes implemented? New Jersey's only NCI-Comprehensive Cancer Center is exploring that opportunity, as it takes the lead in a national initiative to improve data collection on cancer treatment.

• share
• favorite_border

A New Jersey couple, which lost two daughters to cancer, has given a $5 million gift to that state's only NCI-designated Comprehensive Cancer Center. The funding will be used toward research, treatment, and fellowship opportunities for breast oncologists.

• share
• favorite_border

More than 40,000 individuals will die of breast cancer in the U.S. this year. In an effort to combat that statistic, researchers at New Jersey's only NCI-designated Comprehensive Cancer Center are testing a new drug combination to see if it stops blood vessel growth needed for tumors to grow and spread.

• share
• favorite_border

Studies estimate that five to ten percent of breast cancer cases are linked to inherited mutations. Such genetic defects significantly increase a woman's chance of getting the disease. A New Jersey scientist was just awarded $1.6 million from the National Cancer Institute to study that critical genetic pathway.

• share
• favorite_border

Why do some women develop breast cancer at an earlier age than others? Researchers at New Jersey's only NCI-designated Comprehensive Cancer Center hope to better answer that question, now that they have expanded a study to identify genetic markers in women with the disease. The trial will now include more healthy volunteers as well.

• share
• favorite_border

One in six men will be diagnosed with prostate cancer, and it is the most frequently diagnosed cancer in males other than skin cancer. A surgeon at New Jersey's only NCI-designated Comprehensive Cancer Center hopes to shed light on those figures, with the help of a $351,000 Department of Defense grant to study hormone treatment-resistant prostate cancer.