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Certain genes that code for proteins have long been known to contribute to cancer progression. But in a frame shift, researchers from Case Western Reserve University School of Medicine recently found that non-coding genes also contribute to the development and spreading of the disease, one of the first known examples of researchers doing so. The lead author of the study reporting this finding, Ahmad Khalil, PhD, assistant professor of genetics and genome sciences at Case Western Reserve School of Medicine, has been awarded a five-year, $1.85 million grant from the National Institutes of Health to build on the discovery, with an eventual aim of pinpointing additional targets for cancer-fighting treatments.

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Case Western Reserve University School of Medicine has received a three-year, $1,118,556 grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to investigate a new imaging approach for diagnosing peripheral arterial disease, a common and potentially serious circulatory problem. More than 200 million people worldwide suffer from the condition.

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Lan Zhou, MD, PhD, associate professor of pathology at Case Western Reserve University School of Medicine, has received a five-year, $2 million grant from the National Cancer Institute of the National Institutes of Health to study human colorectal cancer. Her work focuses on the effect of the imbalance of the gut microbiome, the immune response, and genetics in the development of adenocarcinoma (cancer that forms in the lining of the glands) through the serrated pathway.

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New research shows that the body’s own microbes are effective in maintaining immune cells and killing certain oral infections.

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Placing trust in doctors to advocate for their health needs, older adults rarely ask for referrals to specialists, specific prescriptions, express concerns or follow-up after medical visits.

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Anthony Wynshaw-Boris, MD, PhD, the James H. Jewell MD ’34 Professor of Genetics and chair of the Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center and Rainbow Babies & Children’s Hospital, has been elected as president of the American Society of Human Genetics, the primary professional membership organization for human genetics worldwide.

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Rising temperatures are melting the Arctic ice, opening new shipping routes and prompting world powers to jostle for access and control.

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Researchers from Case Western Reserve University School of Medicine have discovered a way to stop immune cell death associated with multiple diseases, including sepsis, inflammatory bowel disease (IBD), and arthritis. The findings, published in Science Immunology, identify a chemical that potently inhibits inflammatory cell death.

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A new study by Case Western Reserve researchers at the School of Dental Medicine found that about 7 percent of children between ages 9 and 17 in orthodontic care were at high risk for sleep-disordered breathing.

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A multidisciplinary research team led by Case Western Reserve University School of Medicine has received a three-year, $936,000 grant to use collaborative computational modeling approaches to promote better community health through more equitable food systems.

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Adopting an Islamic concept of coping with spiritual struggles, known as “spiritual jihad,” is associated with post-traumatic growth and virtuous behaviors—and related to reductions in anxiety and depression, according to a new Case Western Reserve University study published in the journal Religions.

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Ashleigh Schaffer, PhD, assistant professor of genetics at Case Western Reserve University School of Medicine, and a team of global genetics experts have discovered a genetic mutation and the faulty development process it triggers, causing a debilitating brain-based disorder in children. The findings, published in Nature Genetics, identify mutations in the alpha-N-catenin gene, (aka CTNNA2), which promotes cell adhesion and causes pachygyria, one of the most serious developmental brain defects in humans. Most patients are severely intellectually impaired, and are unable to walk or care for themselves. Children diagnosed with the rare disease have a life expectancy of about 10 years.

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Juveniles who complete diversion programs for their crimes are less likely to continue their criminal activity as adults, according to new research from Case Western Reserve University.

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A cutting-edge laboratory technique that turns human stem cells into brain-like tissue now recapitulates human brain development more accurately than ever, according to a new study from Case Western Reserve University School of Medicine. The study, published in Nature Methods, demonstrates how to grow brain “organoids”—self-organizing mini spheres that now contain all the major cell types found in the human cerebral cortex—in laboratory dishes.

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Research published today in the journal Nature provides new understanding about how drugs can repair damaged brain cells that cause disability in patients with multiple sclerosis. Led by researchers at Case Western Reserve University School of Medicine, the study suggests new drug targets and potent early-stage drug candidates could lead to regenerative medicines for multiple sclerosis and other debilitating neurological diseases.

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Red-light cameras don’t reduce the number of traffic accidents or injuries at intersections where the devices are installed, according a new analysis by Case Western Reserve University.

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Scientists have long known that RNA encodes instructions to make proteins. The building blocks that comprise RNA—A, U, C, and Gs—form a blueprint for the protein-making machinery in cells. In a new study published in Nature, scientists describe how the protein-making machinery identifies alternative initiation sites from which to start protein synthesis.

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Supplementing a single protein found in the spinal cord could help prevent symptoms of Lou Gehrig’s disease, according to a new study out of Case Western Reserve University School of Medicine. Researchers found high levels of the protein—called mitofusion 2 or Mfn2—prevented nerve degeneration, muscle atrophy, and paralysis in a mouse model of the disease. Since Mfn2 is often depleted during Lou Gehrig’s, the new study suggests supplementing it could be a novel therapeutic approach for the disease.