Up to two years following elective, arthroscopic hip surgery, a substantial proportion of patients reported troubling new health issues ranging from sleep problems, to arthritis to cardiovascular disease.
In the quest to develop a vaccine that triggers the immune system to prevent HIV infection, researchers have focused on identifying and eliciting a particular type of antibody that is capable of neutralizing the virus.
Using a clinical checklist to identify eligible patients, doctors were able to shorten the antibiotic duration for patients with uncomplicated staphylococcal bloodstream infections by nearly two days, Duke Health researchers report.
In a study of 1,978 older adults publishing Sept. 21 in the journal Scientific Reports, researchers at Duke Health and the Duke Clinical Research Institute found people with irregular sleep patterns weighed more, had higher blood sugar, higher blood pressure, and a higher projected risk of having a heart attack or stroke within 10 years than those who slept and woke at the same times every day.
IVF experts disagree about whether transferring a fresh or frozen embryo to a patient’s womb offers the best opportunity for healthy babies. According to a study of almost 83,000 IVF patients published August 20 in the journal Fertility and Sterility, there is no one-size-fits-all solution. The best technique may vary, depending on how many eggs the patient produces.
Researchers at Duke Cancer Institute have tracked the missing T-cells in glioblastoma patients. They found them in abundance in the bone marrow, locked away and unable to function because of a process the brain stimulates in response to glioblastoma, to other tumors that metastasize in the brain and even to injury.
Immune cells that normally rush in to protect the eyes from infection might actually be disrupting moisturizing glands and causing dry eye, a disease that afflicts more than 30 million people in the United States.
A research team led by Duke Cancer Institute scientists has found that this blood cancer infiltrates the central nervous system not by breaching the blood-brain barrier, but by evading the barrier altogether.
A genetically modified poliovirus therapy developed at Duke Cancer Institute shows significantly improved long-term survival for patients with recurrent glioblastoma, with a three-year survival rate of 21 percent in a phase 1 clinical trial.
African-American men with advanced prostate cancer might be more responsive than white men to an anti-androgen drug and steroids, according to a study led by Duke Cancer Institute researchers.
Contrary to current perceptions, certain African-American men with advanced prostate cancer have as good a chance of survival as white men and might actually have a small advantage, according to a new analysis of more than 8,000 patients who participated in clinical trials.
A software tool to automatically calculate how extensively bones have been infiltrated by prostate cancer is both accurate and speedy, capturing key prognostic information related to survival and the development of symptoms over time.
Do metastatic cancer tumors "break bad" or are they "born bad"? In a study publishing the week of May 14 scientists found that in the colorectal tumors they examined, invasive cancers are born to be bad, and this tendency can potentially be identified at early diagnosis.
Approach could guide research for inherited blindness treatment in humans
Women still at higher risk; new research could improve prevention
A simple, one-page form given to patients ahead of their doctor visit can significantly improve satisfaction with the care they receive, according to a study by Duke Health researchers.
Using chemotherapy along with aptamers -- lab-made molecules that function like antibodies -- Duke Health researchers showed that they can zero in on and kill prostate cancer tumors in mice while leaving healthy tissue unscathed.
Scientists have previously shown that when one animal watches another performing a motor task, such as reaching for food, mirror neurons in the motor cortex of the observer's brain start firing as though the observer were also reaching for food. New Duke research appearing March 29 in the journal Scientific Reports suggests mirroring in monkeys is also influenced by social factors, such as proximity to other animals, social hierarchy and competition for food.
New data shows that all moderate or vigorous exercise can add up to reduce the risk of disease or death, even if you are exercising only in short bursts throughout the day.
A 12-week mobile health, or mHealth, program not only kept cardiac rehab patients from losing ground, it appeared to help them maintain and even gain fitness.
Doctors often cite the high price of a prescription drug as a reason they don't prescribe it, while patients similarly say that cost is a main reason they quit taking a drug. Removing this financial barrier might increase the use of evidence-based therapies, improve patient adherence to those medications, and potentially save lives. That theory was tested in a study of heart attack survivors led by the Duke Clinical Research Institute; findings were presented March 11 at the American College of Cardiology annual scientific sessions meeting in Orlando.
Doctors evaluating patients for blockages in the heart are aided by having a good roadmap of the vascular terrain before they can insert stents to clear the impasse. Two technologies have been used with equal success, but now a study presented March 10 at the American College of Cardiology annual meeting by Duke cardiologists shows that the newer method carries a much lower cost, potentially saving each patient at least $800.
About 3 out of 4 Americans agree that smoking cigarettes causes health problems, but public perception of the risks posed by smoking may be declining, according to a Duke Health study published in the journal Drug and Alcohol Dependence.
Despite reports in recent years suggesting childhood obesity could be reaching a plateau in some groups, the big picture on obesity rates for children ages 2 to 19 remains unfavorable, according to a new analysis from Duke Health researchers.
Duke Health has become the first healthcare institution in the U.S. to be awarded the highest honor for analytic capabilities by HIMSS Analytics, a global healthcare IT market intelligence, research and standards organization.
Treating food allergies might be a simple matter of teaching the immune system a new trick, researchers at Duke Health have found. In a study using mice bred to have peanut allergies, the Duke researchers were able to reprogram the animals' immune systems using a nanoparticle delivery of molecules to the lymph nodes that switched off the life-threatening reactions to peanut exposures.
A drug used to slow cognitive decline in Alzheimer's disease could offer clues on how drugs might one day be able to reverse brain changes that affect learning and memory in teens and young adults who binge drink.
A research team at the Duke Cancer Institute has found a new way to keep the immune system engaged, and is planning to test the approach in a phase 1 clinical trial.
A new study from Duke Health has found pregnant women experienced less secondhand smoke exposure since the 2009 passage of the ‘smoking ban’ in North Carolina, which outlawed smoking inside public places such as bars and restaurants.
Duke Health researchers found baseball players with higher scores on vision and motor tasks completed on large touch-screen machines called Nike Sensory Stations had better on-base percentages, more walks and fewer strikeouts -- collectively referred to as plate discipline -- compared to their peers.
Compared to younger adults, older people have higher rates of complications from surgery. But many problems can be avoided by intervening with assessments and risk-reduction strategies before, during and after procedures.
Duke Health researchers, publishing in the Jan. 4 issue of the New England Journal of Medicine, found significantly improved survival among patients with a severe form of scleroderma who underwent chemotherapy, whole body radiation and a stem cell transplant. Patients also had less need for immune suppressant drugs after transplant.
Researchers at the Duke Human Vaccine Institute have led an effort to develop a more accurate way to gauge the incidence of HIV infections in large populations, which will improve research and prevention strategies worldwide.
Asthma affects almost 1 in 10 children in the U.S. and is a leading cause of emergency room visits and hospitalizations in preschoolers. According to new research from Duke Health and collaborators, symptoms may be worse for children ages 2 to 5 who are overweight.
Researchers at Duke Health are working to expand the medical toolkit for treating Lyme disease by identifying vulnerable areas of the disease-causing bacterium that could lead to innovative therapies.
Large national study shows the life-saving potential of coordinating EMS, hospital responses
Technology that keeps track of how your smartphone is oriented can now give $50,000 ultrasound machines many of the 3-D imaging abilities of their $250,000 counterparts — for the cost of a $10 microchip. Doctors and engineers from Duke and Stanford universities will demonstrate their device Oct. 31 at the American College of Emergency Physicians (ACEP) Research Forum in Washington, D.C.
An infusion of cells from a child’s own umbilical cord blood appears to improve brain connectivity and motor function in children with spastic cerebral palsy, according to a randomized clinical trial published this week by Stem Cells Translational Medicine.
About a quarter of adults whose marijuana use is problematic in early adulthood have anxiety disorders in childhood and late adolescence, according to new data from Duke Health researchers.
Researchers have known for decades that fevers in the first trimester of pregnancy increase risk for some heart defects and facial deformities such as cleft lip or palate. Exactly how this happens is unclear. Duke researchers now have evidence indicating that the fever itself, not its root source, is what interferes with the development of the heart and jaw during the first three to eight weeks of pregnancy.
An international research effort led by Duke Cancer Institute scientists has been working to better understand the genetic underpinnings of the most prevalent form of this cancer -- diffuse large B cell lymphoma – and how those genes might play a role in patients’ responses to therapies.
States that fully expanded their Medicaid programs under the Affordable Care Act cut their rates of uninsured cancer patients by more than half between 2011 and 2014. Black patients and those living in the highest poverty areas saw the greatest benefit from Medicaid expansion, according to a Duke Cancer Institute analysis.
An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body’s own capacity to fight malignancies by activating an inflammation process that counter’s the ability of cancer cells to evade the immune system.
Researchers at Duke Cancer Institute have not only untangled an unusual wiring system that cancer cells use for carbohydrate metabolism, but also identified a natural compound that appears to selectively shut down this system in laboratory studies.
Compared to people who live in predominantly white neighborhoods, those who live in predominantly black areas are much less likely to receive CPR or defibrillation from a bystander when their heart suddenly stops beating while they are at home or out in the community.
In a large, international study led by the Duke Clinical Research Institute and five coordinating centers around the world, an informational campaign aimed at patients, families and physicians led to a 9-percent absolute increase in the use of anticoagulation therapies. The increased drug adherence was accompanied by a small, but notable reduction in the risk of stroke.
A third of insured people with cancer end up paying more out-of-pocket than they expected, despite having health coverage, researchers at the Duke Cancer Institute have found.
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