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If you call 911 due to a hypoglycemic episode there is a roughly 3 in 4 chance the emergency medical responder will be unable to give you glucagon

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BOSTON – (November 29, 2017) – Scientists at Joslin Diabetes Center have taken another step toward solving a long-standing puzzle about heart health in type 2 diabetes, with a finding that eventually may point towards more personalized patient care.People with type 2 diabetes, who are at least twice as likely to develop cardiovascular disease (CVD) as people without the condition, generally can reduce their risks by careful controlling their glycemic (blood glucose) levels.

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BOSTON – (October 3, 2017) – If you’re one of the two billion people in the world who are over-weight or obese, or the one billion people with fatty liver disease, your doctor’s first advice is to cut calories—and especially to cut down on concentrated sugars such as high-fructose corn syrup, a sugar found in sweetened beverages and many other processed foods.

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Joslin’s research involves a wide variety of biologic disciplines ranging from the most basic model systems to studies of pathophysiology in animal models and humans to the evaluation of new therapies in patients. The primary aim of the Joslin DRC is to provide a facilitating framework for conducting multi-disciplinary basic and clinical research and to encourage the scientific development of young investigators. Special attention is paid to fostering rapid translation of basic research.

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Researchers at Joslin Diabetes Center have identified an unexpected natural protective factor against chronic inflammation that drives cardiovascular disease in type 2 diabetes.

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“People are living longer with type 1 diabetes, and the onset of complications is taking longer,” says Hillary Keenan, Ph.D., a Joslin Diabetes Center Assistant Investigator and co-Principal Investigator on the Joslin 50-Year Medalist Study.

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The award recognizes Aiello's research to determine the underlying biochemistry and molecular mechanisms of diabetic retinopathies, then develop and test novel therapeutic interventions through rigorous translational and clinical trial research.

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Joslin Diabetes Center has established a Center for Cell-Based Therapy for Diabetes (CCTD), the goal of which is to lead the development and translation of cell-based interventions to treat and cure diabetes and its complications.

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Doctors rely mostly on two biomarkers -- urinary albumin to creatinine ratio (ACR) and estimated glomerular filtration rate -- to identify those at higher risk of kidney failure. But researchers say those criteria miss a large proportion of patients who are at high risk of the disease and fail to predict accurately time of onset of ESRD. Researchers from Joslin Diabetes Center have developed a prognostic tool that accurately predicts the risk of end stage renal disease (ESRD) in patients with both type 1 and type 2 diabetes.

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Diabetes researchers have puzzled for decades about why insulin-producing beta cells in one pancreatic islet often look and behave quite differently than their counterparts in the same islet or in nearby islets. Using newly identified cellular markers of aging, Joslin Diabetes Center scientists now have shown that this diversity may be driven at least in part by differently aged beta cell populations within the pancreas.

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Scientists at Joslin Diabetes Center now have identified a route by which fat also can deliver a form of small RNAs called microRNAs that helps to regulate other organs. This mechanism may offer the potential to develop an entirely new therapeutic approach.

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Joslin Diabetes Center will take part in two clinical trials this year to test artificial pancreas systems designed to automatically monitor and regulate blood glucose levels in people with type 1 diabetes, which would replace traditional methods of managing the disease such as testing blood glucose levels by finger stick or using continuous glucose monitoring systems with separate, non-integrated delivery of insulin by either injections or a pump.

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American Diabetes Association awards Aleksandar Kostic, PhD, of Joslin Diabetes Center, $1.625M for the development of a novel experimental system designed to improve our understanding about how bacteria in the gut (the gut “microbiome”) may contribute to the autoimmune attack that leads to type 1 diabetes.

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Participants in Joslin's Why WAIT (Weight Achievement and Intensive Management) program lost substantial amounts of weight, and even those who maintained relatively little loss of weight after five years demonstrated reduced risks of cardiovascular disease.

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People with any form of diabetes are at greater risk of developing cardiovascular conditions than people without the disease. Moreover, if they undergo an operation to open up a clogged artery by inserting a “stent” surgical tube, the artery is much more likely to clog up again. However, researchers at Joslin Diabetes Centers now have uncovered an explanation for why these procedures often fail, which may lead toward better alternatives.

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Laurie J. Goodyear, PhD, at Joslin Diabetes Center will be part of the NIH's new MoTrPAC consortium and will help map molecular changes from physical activity.

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Most people struggle with their weight and are less active than ever before. Taken together, this toxic lifestyle can lead to serious health problems. The truth is that 86 million American adults—more than one out of three—have prediabetes. What’s scarier is that nine out of 10 don’t know they have it.

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Joslin Diabetes Center investigators are shedding light on how the success of such microbiome treatments may be affected by genetics of the individual or animal being treated.

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Genes play a role in how people with type 2 diabetes at high risk of cardiovascular disease risk respond to intensive glycemic control as an intervention to prevent the disease.