Two Sanford Burnham Prebys Medical Discovery Institute scientists have been honored as 2020 Fellows by the American Association for the Advancement of Science (AAAS). Eva Engvall, Ph.D., professor emerita; and Hudson Freeze, Ph.D., professor and director of the Human Genetics Program, were named Fellows in a vote by the AAAS Council.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue and improve treatment efficacy—a scientific first and major advance for the field of regenerative medicine. The discovery, published in the Proceedings of the National Academy of Sciences (PNAS), could improve current stem cell therapies designed to treat such neurological disorders as spinal cord injury, stroke, amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders; and expand their use to new conditions, such as heart disease or arthritis.
Jerold Chun, M.D., Ph.D., a professor and senior vice president at Sanford Burnham Prebys Medical Discovery Institute, has been named a “Highly Cited Researcher” by Clarivate, the global analytics company. The honor recognizes researchers who have demonstrated a significant influence in their chosen field of study through the publication of multiple works that have been cited by their peers.
Scientists at Sanford Burnham Prebys Medical Discovery Institute, University of California San Diego School of Medicine and Hopp Children’s Cancer Center Heidelberg (KiTZ) have demonstrated that personalized drug screens can be used to identify new therapeutic candidates for medulloblastoma. The approach measures the effectiveness of therapeutics using tumor cells obtained from a biopsy and can be performed in a few days—making it one of the quickest sources of information used in clinical decision-making.
Sanford Burnham Prebys Medical Discovery Institute today announced that two faculty members, Peter Adams, Ph.D., and Jerold Chun, M.D., Ph.D., have received National Institutes of Health (NIH) Director’s Transformative Research Awards. The awards, which total $8.5 million and are two of only nine granted in 2020, come from the NIH Common Fund’s High-Risk, High-Reward Program.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that blocking the construction of nuclear pores complexes—large channels that control the flow of materials in and out of the cell nucleus—shrank aggressive tumors in mice while leaving healthy cells unharmed. The study, published in Cancer Discovery, a journal of the American Association for Cancer Research, reveals a new Achilles heel for cancer that may lead to better treatments for deadly tumors such as melanoma, leukemia and colorectal cancer.
Malene Hansen, Ph.D., has been awarded a three-year, $300,000 Breakthroughs in Gerontology (BIG) Award. The BIG Award is sponsored by The Glenn Foundation for Medical Research in collaboration with the American Federation for Aging Research (AFAR), and provides funding for research projects aimed at discoveries that address aging and health span. Hansen is a professor in the Development, Aging and Regeneration Program at Sanford Burnham Prebys Medical Discovery Institute.
Scientists at Sanford Burnham Prebys Medical Discovery Institute today announced they have released Coronascape (coronascape.org), a customized version of the Metascape bioinformatics platform that removes big-data analysis hurdles for biologists. Coronascape will enable scientists to interpret the growing body of big data related to COVID-19. More than 23,000 papers about COVID-19 have been published since January 2020—and this number continues to rise exponentially.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have received a $3 million grant from the National Institutes of Health (NIH) to study how SARS-CoV-19 weakens the immune system—and identify drugs to help infected individuals recover. The research will be led by Carl Ware, Ph.D., director of the Institute’s Infectious and Inflammatory Disease Center, and builds on the Institute-wide initiative to develop therapeutics to treat COVID-19.
Scientists at Sanford Burnham Prebys Medical Discovery Institute, Camino Pharma, LLC and University of California San Diego School of Medicine have been awarded an $11.4 million grant from the National Institute on Drug Abuse (NIDA) at the National Institutes of Health (NIH) to advance a novel drug candidate for nicotine addiction into first-in-human Phase 1 studies. The drug targets a neuronal signaling pathway underlying addictive behaviors, and would be a first-in-class medication to help people quit smoking.
Scientists at Sanford Burnham Prebys, Fondazione Santa Lucia IRCCS, and Università Cattolica del Sacro Cuore in Rome have shown that pharmacological (drug) correction of the content of extracellular vesicles released within dystrophic muscles can restore their ability to regenerate muscle and prevent muscle scarring. The study, published in EMBO Reports, reveals a promising new therapeutic approach for Duchenne muscular dystrophy (DMD), an incurable muscle-wasting condition.
Sanford Burnham Prebys Medical Discovery Institute has been awarded a $4.5 million grant from the National Institutes of Health (NIH) to identify new therapies for mental health disorders. The research will be headed by Layton Smith, Ph.D., and Michael Jackson, Ph.D., of the Institute’s Conrad Prebys Center for Chemical Genomics. The funding supports the discovery of new classes of drugs that target “orphan” receptors to treat psychological conditions such as schizophrenia, depression, anxiety and substance abuse.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have uncovered a novel drug target, a protein called PPP1R1B, that stops the deadly spread of pancreatic cancer, called metastasis, when inhibited in mice. Published in Gastroenterology, the findings are a first step toward a potential treatment for one of the deadliest cancers known today.
A Nature study authored by a global team of scientists and led by Sumit Chanda, Ph.D., professor at Sanford Burnham Prebys Medical Discovery Institute, has identified 21 existing drugs that stop the replication of SARS-CoV-2, the virus that causes COVID-19.
Sanford Burnham Prebys Medical Discovery Institute has received an award from the California Institute for Regenerative Medicine (CIRM) to advance promising drug candidates for COVID-19. The research team will test two existing drugs against “mini lungs in a dish” that have been infected with SARS-CoV-2.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that the blood protein vitronectin is a promising drug target for dry age-related macular degeneration (AMD), a leading cause of vision loss in Americans 60 years of age and older. The study, published in the Proceedings of the National Academy of Sciences (PNAS), also holds implications for Alzheimer’s and heart disease, which are linked to vitronectin.
Sanford Burnham Prebys Medical Discovery Institute today announced that its Board of Trustees has appointed C. Randal “Randy” Mills, Ph.D., as chief executive officer, effective immediately. Mills joins the Institute with decades of experience as an entrepreneur and transformational leader in the biomedical industry.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have demonstrated the therapeutic potential of PRMT5 inhibitors to sensitize unresponsive melanoma to immune checkpoint therapy. PRMT5 inhibitors are currently in clinical trials in oncology, and this research provides a strong rationale for evaluating the drugs in tumors that are not responsive to immune checkpoint therapy. The study was published in Science Translational Medicine.
Sanford Burnham Prebys Medical Discovery Institute is pleased to announce that the American Cancer Society (ACS) has awarded Brooke Emerling, Ph.D., a Research Scholar Grant to study a new approach to targeting tumors that have a mutation in the p53 gene—the most altered gene in human cancers. The grants are often a career-launching award for “rising stars” in the cancer research arena.
Sanford Burnham Prebys Medical Discovery Institute today announced a research agreement with Eli Lilly and Company (Lilly) to characterize Lilly’s next-generation anti-SARS-CoV-2 antibodies. These collaborative studies aim to build on Lilly’s current portfolio of neutralizing antibodies by exploring novel cocktails, half-life extension technologies and strategies to further enhance potency.
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