A Johns Hopkins scientist and a team of collaborators have discovered how precancerous moles may progress to melanomas, the most deadly type of skin cancer. The report describes a link between two genes that trigger skin cancers and could serve as early diagnostic markers for the disease.
The 10th edition of the Hopkins guide to AIDS care, Medical Management of HIV Infection mirrors a decade's history of medical successes and challenges. The internationally renowned publication began in 1991 as a 28-page booklet with 10 pages devoted to anti-HIV therapy as well as treatment of opportunistic infections and complications. It is now a 356-page book.
Researchers at the Johns Hopkins Oncology Center have developed a new gene-based therapy that they hope will transform one of the most lethal types of adult leukemia to one of the most treatable.
Cholesterol is instrumental in HIV's ability to infiltrate cells, and removing this fatty material from a cell's membrane blocks infection, according to a Johns Hopkins study.
Acting on a scientific hunch, Hopkins medical sleuths set out to find individuals with an extremely rare disorder affecting their ability to internally process water. Using international blood banks, the investigators identified two such persons, confirming their belief that the absence of a certain protein interferes with the body's ability to regulate its water levels.
The Johns Hopkins scientists who first created "mighty mice" by genetically engineering animals with a missing growth regulator called myostatin have now created a second group of mice whose genetic makeup shows it's possible to get the same effect by blocking the gene for myostatin, rather than entirely knocking it out.
A team of scientists from Johns Hopkins Children's Center and two other institutions have found that low levels of HIV-1 virus in the blood of children and adults undergoing a common combination drug therapy does not necessarily indicate the virus is becoming resistant to these life-prolonging medications.
The care of asthmatic African Americans falls short of many recommendations contained in national guidelines, compared to whites, according to a new study by Johns Hopkins researchers.
1) Faulty bee tests make for stinging surprises; 2) Mexican-Americans at high risk for diabetic retinopathy; 3) Novel measure of blood cholesterol better predicts death from heart disease; 4) Women facing cancer treatment may still have fertility options.
Researchers from Johns Hopkins and Toshiba Corporation Medical Systems Company have formed a joint research program at Hopkins to develop new, minimally invasive procedures using combinations of CT scans and fluoroscopy.
The Johns Hopkins Medicine Department of Radiology has been selected to take part in the first major study assessing the value of digital mammography versus standard mammography. The study, called the American College of Radiology Imaging Network (ACRIN) study, is funded with a $25 million grant from the National Cancer Institute.
Researchers at Johns Hopkins Children's Center report success in treating sickle cell disease in mice with a modified bone marrow transplant. The finding adds further support to human trials now under way at the Children's Center.
Armed with evidence from a recent study of latex allergy skin reactions in patients' scientists at Johns Hopkins encourage the Food and Drug Administration and drug makers to label all current vials as "containing natural rubber" where appropriate and convert to using synthetic rubber for all medicine bottle stoppers.
On July 13, an 18-wheeler will leave Maryland, bound for the Navajo Indian Reservation in Arizona. On board will be an astonishing array of the latest in digital breast mammography equipment and sophisticated satellite systems for relaying the mammography images back to expert radiologists at the U.S. Army's Walter Reed Medical Center in Maryland and to Johns Hopkins in Baltimore.
Resistance training burns calories for more than an hour after a workout and may be as important as aerobic exercise for women in the fight against fat, according to researchers at Johns Hopkins and Arizona State universities.
For the first time, Hopkins is the top earner of AIDS research funding from the National Institutes of Health for fiscal year 2000.
Older people who are more fit and have less body fat may also have a better outlook on life than their less active, less lean counterparts, according to a Johns Hopkins study.
The furry- or feathered-costumed mascots at professional ball games may have more in common than entertaining the crowd: a high propensity for heat illness and other assorted injuries, according to a Johns Hopkins study.
Spending more time and money up front to keep injection drug users with latent tuberculosis (TB) on strict, anti-TB regimens will improve patient outcomes and save money in the long run, according to a new study by Johns Hopkins researchers.
A Johns Hopkins study of elderly persons found that many have either moderate or severe asthma that has been underdiagnosed or undertreated.
Approximately one in five older people -- even those with good health insurance -- misuse their asthma drugs, and doctors fail an even greater proportion by not managing their care aggressively or giving them enough information to manage symptoms on their own, according to a report from Johns Hopkins researchers.
Investigators at Johns Hopkins have proven that distracting patients during and after bronchoscopy with the gurgle of a brook and a colorful panorama of tranquil meadow improves pain control by approximately 43 percent.
Doctors who do not periodically reevaluate their patients' asthma severity are failing to provide good care to asthma sufferers, report Johns Hopkins physicians May 20 at the American Thoracic Society's annual meeting.
Researchers at Johns Hopkins and the University of Pittsburgh report promising results in tests of a new prostate cancer drug known as ABT-627 made by Abbott Laboratories (Abbott Park, IL).
Results of an eight-year national clinical trial show that combining chemotherapy and radiation treatment at the same time offers patients with advanced cancer of the larynx, or voice box, better hope of preserving their voice.
Johns Hopkins today announced the introduction of the Palm OS(tm) version of its digital Guide to Antibiotics and Infectious Disease -- the ABX Guide -- designed to give physicians free and up-to-the-minute information on antibiotics and their proper use. The ABX Guide offers information on more than 190 drugs and more than 140 diseases treated by both specialists and primary care physicians.
David Satcher, M.D., Ph.D., United States Surgeon General, is the commencement speaker for Johns Hopkins University School of Medicine May 24, 2001.
Research initiated by Johns Hopkins has found that a mouse bone marrow stem cell is capable of developing into the specialized cells lining intestines, lung and skin. This study provides some of the first clear evidence that a transplanted bone marrow stem cell can not only reconstitute bone marrow, but also may play a role in healing these other tissues and organs as well.
News Tips from Hopkins at the APS-SPR 2001 Conference April 27 - May 1, Baltimore Convention Center
The following news tips are based on upcoming presentations at two pediatric medical meetings in Baltimore.
A team of researchers from the Johns Hopkins Children's Center and four other medical centers have found that the antidepressant drug fluvoxamine significantly lowers anxiety without major side effects in most children who take it.
John Phillips Dorst, M.D. director of pediatric radiology at Johns Hopkins for more than two decades, died of complications from a brain tumor on April 17 at Brightwood Genesis Eldercare in Lutherville, Md.
After a half-century of looking at everything from Accutane to zinc, dermatologists still can't prove which acne treatments and drugs work best, a team at Johns Hopkins Children's Center finds after combing the scientific literature.
Unexplained weight loss, exhaustion, a weak grip, slow walking speed and low energy -- the hallmarks of frailty -- are most likely to strike women, African Americans, the less educated and the poor, according to a nationwide study of more than 5,000 older adults.
A research team led by a Johns Hopkins Children's Center scientist has found the strongest evidence yet that a virus may contribute to some cases of schizophrenia.
Winners of the Johns Hopkins Young Investigators' awards cite different reasons for becoming scientists, but have in common a knack for elegant research, a keen discipline to see it through and an unusual ability to communicate what they're doing.
Johns Hopkins today launched a rigorously peer-reviewed database and a point of care decision-support system designed to give office and hospital-based physicians free and up-to-the-minute information on antibiotics and their proper use.
Daniel N. Sauder, M.D., an internationally acclaimed dermatologist, has been appointed the new director of dermatology at Johns Hopkins, effective July 1. Sauder succeeds dermatologist Grant Anhalt, M.D., who served as interim director.
Researchers at Johns Hopkins announce that a novel method of modifying an allergen, such as ragweed, by attaching a synthetic piece of DNA to it, is showing promise in initial clinical trials. The finding may lead to a more effective vaccine for treating allergic diseases such as hay-fever or asthma.
John Hopkins researchers have developed the first color-coded tracking system to see how receptors on the surface of a living cell transmit signals to the cell's interior and regulate a wide range of biological processes. The technology should significantly speed up the search for drugs needed to treat heart disease, cancer, asthma and other ailments. (Science, 3-23-01)
Scientists discovered the gene for Huntington's disease in 1993, but in all that time, they couldn't explain how the gene leads to the death of a small patch of nerve cells in a key part of the brain. (Science, 3-01)
American hospitals with a shortage of "intensivists" to treat patients in their intensive care units could benefit from having such experts monitor their patients offsite via computer, Johns Hopkins researchers have found. (Critical Care Medicine)
A new Johns Hopkins Children's Center study reveals that caring for a chronically ill child can be a positive experience for many mothers and families. (Ambulatory Pediatrics, 3-01)
The following news tips from Johns Hopkins are based on abstracts or posters to be presented at the American College of Cardiology's 50th Scientific Sessions, held March 18-21 in Orlando, Fla.
Johns Hopkins researchers report that a portable device that's "a cross between a pager and your own mother" can, within half a year, lead to a significant drop in the amount of virus HIV patients carry in their blood or spinal fluid.
Scientists at Johns Hopkins and Tsukuba University in Japan have confirmed the existence of a long-suspected natural system the body uses to block the cancer-causing effects of toxic chemicals in food and the environment. (PNAS)
A new study by Johns Hopkins Children's Center neurologists suggests that baclofen, a drug long thought to be effective in reducing the vocal and motor tics associated with Tourette syndrome, improves a patient's overall sense of well-being but does not significantly reduce tics. (Neurology, 3-01)
A Johns Hopkins neurologist, inspired by the plight of a young patient, has established a nationwide consortium of Centers of Excellence for research and treatment of the often-paralytic neurological disease transverse myelitis (TM).
Researchers have developed the first genetic profile for Crohn's disease and ulcerative colitis, two types of inflammatory bowel diseases. (Human Molecular Genetics, 3-01)
Even though aspirin's pain-killing capacity was well known to Hippocrates in the fifth century B.C., exactly what it does remains somewhat of a mystery. Now, Johns Hopkins researchers have shown that aspirin inhibits interleukin-4, a protein involved in allergic reactions and inflammation. (Blood, 3-01)
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