Newswise — Washington, D.C., August 29, 2022 — Melanie McCauley of Fort Washington, Md., first experienced angina, or chest pain, at a bowling tournament. The tightness and pain in her chest, nausea, and sweating became so intense that she ended up in an ER. After a battery of tests, including an angiogram, which is an X-ray of the heart, found no blockages in her coronary arteries, she was sent home.

She returned to the ER several more times over the next few months. Each time, doctors assured her there was nothing wrong. When her cardiologist referred her to MedStar Washington Hospital Center, Hayder Hashim, MD, determined a definitive diagnosis: coronary microvascular dysfunction (CMD), a condition in which the heart’s smallest arteries don’t dilate properly. As a result, the heart doesn’t get enough oxygen-rich blood.

CMD historically has been difficult to diagnose because these tiny arteries are not visible on an angiogram. In fact, an estimated 50 percent of all angina cases are now attributed to CMD, with women accounting for most incidences. Yet, detecting CMD has remained elusive. Until now.

MedStar Heart & Vascular Institute became one of only a few programs in the nation to use the Coroventis CoroFlow Cardiovascular System. It is an advanced software-based platform that, along with a special guidewire, can effectively measure the workings of the heart’s tiniest arteries, allowing physicians to confirm the cause of their patient’s unexplained chest pain.

“For the first time, we now have the ability to correctly diagnose and then treat coronary microvascular dysfunction,” said Dr. Hayder Hashim, an interventional cardiologist at MedStar Washington Hospital Center. “As such, this innovative approach has the potential to help us prevent subsequent damage, improve quality of life, and give patients peace of mind.”

The assessment begins with an angiogram, followed by threading the guidewire through the left anterior descending artery. Once in place, the wire measures true blood flow and microvascular resistance, which the CoroFlow software then determines whether the heart’s smallest arteries are functioning properly.

“Patients with coronary microvascular dysfunction often feel dismissed by their doctor, like it’s ‘all in their head,’” said Brian Case, MD, an interventional cardiologist at MedStar Southern Maryland Hospital Center. “Yet, they know their pain is real, regardless of the lack of medical evidence. And that leaves them worried, unhappy, and even distrustful of the medical system. Even physicians are frustrated by their inability to provide optimal care for their patients. The CoroFlow platform should help both parties get the answers they seek.”

For Melanie McCauley, when Dr. Hashim told her she had coronary microvascular dysfunction, she felt immediate relief. “I started crying. I finally had a diagnosis and Dr. Hashim assured me that what I was experiencing was not in my head.”

After a diagnosis, CMD patients are returned to their referring physician for treatment and management. CMD is often treated with medications and/or lifestyle changes to control risk factors and reduce symptoms.

Doctors Hayder Hashim, Brian Case, and Itsik Ben-Dor are the only specialists in the area to offer the approach. Combined, they have performed 140 of these procedures since its debut last year. They are also creating a CMD registry to follow patients long-term and further advance understanding of the disease. 



MedStar Heart & Vascular Institute, founded at MedStar Washington Hospital Center in Washington, D.C., is a national leader in the research, diagnosis, and treatment of cardiovascular disease, and has been recognized by U.S. News & World Report and The Society of Thoracic Surgeons as one of the top cardiovascular programs in the nation. It is comprised of a network of 10 hospitals and 175 cardiovascular physicians located throughout Maryland, Northern Virginia and the Greater Washington, D.C., region. MedStar Heart & Vascular Institute’s cardiac surgery program is one of the busiest and best regarded in the mid-Atlantic region with more than 2,200 surgeries performed annually. It is among the top five centers in the country for Ventricular Assist Device (VAD) implantation, and 29 heart transplants were performed in 2020, making it one of the most active circulatory support centers in the nation.