Research Alert

Article title: SNX27 regulates DRA activity and mediates its direct recycling by PDZ-interaction in early endosomes at the apical pole of Caco2 cells

Authors: Karen Bannert, Peggy Berlin, Johannes Reiner, Heiko Lemcke, Robert David, Robby Engelmann, Georg Lamprecht

From the authors:“The results from this study, our previous data and findings from the literature indicate that different [downregulated in adenoma (DRA)] recycling routes exist. Furthermore, not only the interaction of DRA with [postsynaptic density 95, disc large, zonula occludens 1] adapter proteins itself but also the function of multiprotein complexes like the [sorting nexin 27] retromer complex are important for its recycling and regulation.”

This study is highlighted as one of May's "best of the best" as part of the American Physiological Society's APSselect program.

SEE ORIGINAL STUDY