Research Alert

Newswise — Article title: Silencing of MYH7 ameliorates disease phenotypes in human iPSC-cardiomyocytes

Authors: Alexandra Dainis, Kathia Zaleta-Rivera, Alexandre Ribeiro, Andrew Chia Hao Chang, Ching Shang, Feng Lan, Paul W. Burridge, W. Robert Liu, Joseph C. Wu, Alex Chia Yu Chang, Beth L. Pruitt, Matthew Wheeler, Euan Ashley

From the authors: “These findings are the first exploration of allele-specific silencing in a human [hypertrophic cardiomyopathy] model and provide a foundation for further exploration of silencing as a therapeutic treatment for MYH7-mutation-associated cardiomyopathy.” 

This study is highlighted as one of August’s "best of the best" as part of the American Physiological Society's APSselect program.

Journal Link: Physiological Genomics