Newswise — PHILADELPHIA— For some surgeries, spinal anesthesia has been increasingly used instead of general anesthesia as a method to provide more comfort to patients and cut down on painkiller use. But research among hip fracture patients shows that this change may actually be having the reverse of its intended effect. The study, led by researchers from the Perelman School of Medicine at the University of Pennsylvania, was published today in Annals of Internal Medicine.

“In our study, patients who got spinal anesthesia did get fewer opioids in the operating room, but they ended up having more pain, and more prescription pain medication use after surgery,” said lead author Mark Neuman, MD, an associate professor of Anesthesiology and past chair of the Penn Medicine Opioid Task Force. “While our study can’t determine conclusively whether this was due to the spinal anesthesia itself or the fact that fewer opioids were given up front, this is a result that should make people examine some of the assumptions informing current care pathways.”

Neuman and his colleagues sought to check whether assumptions about spinal anesthesia and lessened pain were accurate. So they examined data from 1,600 patients who’d had hip fracture surgery between 2016 and 2021 at dozens of hospitals across the United States and Canada. The study was called the REGAIN Trial, and roughly half of the enrollees had spinal anesthesia for their surgery while the other half had general anesthesia. Each patient was asked to assess their levels of pain (on a scale of 1 to 10) at varying intervals, and to indicate their prescription painkiller use following the procedure.

Overall, patients rated their worst pain in the day following their procedure, with the spinal anesthesia patients indicating slightly higher levels of their worst pain, averaging 7.9 out of 10 compared to 7.6 among those who’d had general anesthesia.

After that, spinal anesthesia patients were 33 percent more likely than the general anesthesia patients to have still taken prescription painkillers roughly two months out from their procedure. There was not a significant difference noticed in prescription pain medicine use at six and 12 months from the surgery, but Neuman was still wary of what he saw.

“Even though the 180- and 365-day findings are not statistically significant, the 60-day finding is still concerning, since there could be medication-related harms like respiratory depression or over-sedation that could still occur over the short term,” Neuman said.

The study follows research from Neuman in 2021 that showed general anesthesia was just as safe for patients who’d suffered a broken hip as spinal anesthesia. Again, that study’s findings went against a relatively widely held assumption in the medical community.

Neuman and his colleagues hope to improve pain care for patients with hip fracture and dementia by finding ways to increase use of peripheral nerve blocks – a form of local anesthetic injection that remains under-used despite recommendations encouraging their use for all hip fracture patients. Additionally, they want to apply the same lens they used in the REGAIN trial – comparing general to spinal anesthetic – to total joint replacements, such as hip replacements.

This study was funded by the Patient-Centered Outcomes Research Institute (1406-18876).



Penn Medicine is one of the world’s leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation’s first medical school) and the University of Pennsylvania Health System, which together form a $9.9 billion enterprise.

The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $546 million awarded in the 2021 fiscal year.

The University of Pennsylvania Health System’s patient care facilities include: the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center—which are recognized as one of the nation’s top “Honor Roll” hospitals by U.S. News & World Report—Chester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; and Pennsylvania Hospital, the nation’s first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.

Penn Medicine is powered by a talented and dedicated workforce of more than 52,000 people. The organization also has alliances with top community health systems across both Southeastern Pennsylvania and Southern New Jersey, creating more options for patients no matter where they live.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2021, Penn Medicine provided more than $619 million to benefit our community.