Research Alert

Article title: Statins activate the NLRP3 inflammasome and impair insulin signalling via p38 and mTOR

Authors: Brandyn D. Henriksbo, Akhilesh K. Tamrakar, Jobanjit S. Phulka, Nicole G. Barra, Jonathan D. Schertzer

From the authors: “We propose that dysregulated [mammalian target of rapamycin] is a common feature of statin-mediated effects on cells responsible for blood glucose control. This may be useful knowledge for mitigating the side-effects of statin while retaining the cholesterol lowering capability of this drug class.” 

This study is highlighted as one of July’s "best of the best" as part of the American Physiological Society's APSselect program.

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