Research Alert

Article title: AICAR and Compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro

Authors: Katrin Böttcher, Lisa Longato, Giusi Marrone, Giuseppe Mazza, Leo Ghemtio, Andrew Hall, Tu Vinh Luong, Stefano Caruso, Benoit Viollet, Jessica Zucman-Rossi, Massimo Pinzani, Krista Rombouts

From the authors: “The results of the study show that activation of [adenosine monophosphate-activated kinase (AMPK)] is involved in [hepatocellular carcinoma (HCC)] tumour-stromal interaction and suggests AMPK as a potential target for novel treatments for the overall stromal derangement typical of chronic liver disease and the associated development of HCC.” 

This study is highlighted as one of March’s "best of the best" as part of the American Physiological Society's APSselect program.