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Article ID: 702120

Rush Transplant Survival Rates Above Expectations

Rush University Medical Center

Adult patients who received liver and kidney transplants at Rush University Medical Center had better-than-expected one-year survival rates, according to the most recent transplantation on the 5-tier system report by the Scientific Registry of Transplant Recipients (SRTR), which was released on Oct. 9.

Released:
12-Oct-2018 11:05 AM EDT

Article ID: 702049

How a common drug causes liver failure

American Society for Biochemistry and Molecular Biology (ASBMB)

High doses of acetaminophen can damage the liver. Researchers have found a new mechanism by which an acetaminophen breakdown product can impair liver proteins. The compound activates a protein modification pathway called glutathionylation. The finding explains how the compound can damage even proteins it doesn't bind to directly.

Released:
11-Oct-2018 12:05 PM EDT

Article ID: 701687

肝移植结合减肥手术可使肥胖患者长期受益

Mayo Clinic

Mayo Clinic的研究显示,相比那些在自行减肥之后接受肝脏移植的患者,同时接受挽救生命的肝脏移植以及减肥手术的肥胖患者在长期保持体重以及代谢并发症上都表现的更好。该研究成果发表在《肝病学》(Hepatology)杂志上。

Released:
4-Oct-2018 3:05 PM EDT

Article ID: 701582

Combinação de cirurgia para perda de peso e transplante de fígado beneficia pacientes obesos no longo prazo

Mayo Clinic

Pacientes obesos submetidos simultaneamente a uma cirurgia para perda de peso e ao transplante do fígado tiveram maior sucesso para manter a redução de peso no longo prazo e tiveram menos complicações metabólicas do que pacientes que perderam peso por conta própria antes de passar por um transplante do fígado, segundo pesquisa da Mayo Clinic. As descobertas foram publicadas no periódico Hepatology.

Released:
3-Oct-2018 2:05 PM EDT

Article ID: 701464

Liver transplant, weight-loss surgery combination benefits obese patients in long term

Mayo Clinic

Obese patients who underwent a life-saving liver transplant and weight-loss surgery at the same time were better able to keep the weight off long term and had fewer metabolic complications than those who lost weight on their own before undergoing a liver transplant, Mayo Clinic research shows. The findings were recently published in Hepatology.

Released:
2-Oct-2018 12:05 PM EDT
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Article ID: 701208

Hopkins Researchers Use Endoscope to Deliver Gene Therapy in Animal Study

Johns Hopkins Medicine

Fixing or replacing faulty genes has emerged as a key to unlocking cures for numerous devastating diseases. But if the new, engineered genes can’t find their way into the patient’s genomic sequence, they won’t help.

Released:
2-Oct-2018 8:00 AM EDT
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Article ID: 701353

No “Reservoir”: Detectable HIV-1 in Treated Human Liver Cells Found to Be Inert

Johns Hopkins Medicine

In a proof-of-principle study, researchers at Johns Hopkins report that a certain liver immune cell called a macrophage contains only defective or inert HIV-1 copies, and aren’t likely to restart infection on their own in HIV-1-infected people on long-term antiretroviral therapy (ART).

Released:
1-Oct-2018 9:00 AM EDT
  • Embargo expired:
    17-Sep-2018 11:00 AM EDT

Article ID: 700462

Liver Allocation System Disadvantages Children Awaiting Transplants

Health Sciences at the University of Pittsburgh

Children are at a considerable disadvantage when competing with adults for livers from deceased organ donors in the U.S. allocation system for liver transplants, a University of Pittsburgh Graduate School of Public Health-led analysis reveals today in JAMA Pediatrics.

Released:
13-Sep-2018 12:00 PM EDT

Article ID: 700557

Big Data Studies Scrutinize Links Between Fatty Liver Disease and How Cells Make Energy

American Society for Biochemistry and Molecular Biology (ASBMB)

Three recent studies dig into how nonalcoholic fatty liver disease affects mitochondria in the liver: how mitochondrial energy production stutters and fails as the disease progresses, and how this affects the organ’s use of nutrients to produce energy.

Released:
14-Sep-2018 10:05 AM EDT
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  • Embargo expired:
    13-Sep-2018 11:00 AM EDT

Article ID: 700321

Caspase-2 Enzyme Inhibition Shows Promise for Ameliorating Fatty Liver Disease

University of California San Diego Health

Researchers at University of California San Diego School of Medicine have discovered using mice and human clinical specimens, that caspase-2, a protein-cleaving enzyme, is a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive liver condition. By identifying caspase-2’s critical role, they believe an inhibitor of this enzyme could provide an effective way to stop the pathogenic progression that leads to NASH — and possibly even reverse early symptoms.

Released:
11-Sep-2018 11:05 AM EDT

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