Intraventricular Transplantation of Autologous Bone Marrow Mesenchymal Stem Cell in Hemorrhagic Stroke
A presentation at the 2016 American Association of Neurological Surgeons Annual Scientific Meeting
Article ID: 652457
Released: 1-May-2016 11:05 AM EDT
Source Newsroom: American Association of Neurological Surgeons (AANS)
Newswise — Winner of the American Association of Neurological Surgeons (AANS) International Travel Scholarship, Asra Al Fauzi, MD, IFAANS, presented his research, Intraventricular Transplantation of Autologous Bone Marrow Mesenchymal Stem Cell in Hemorrhagic Stroke, during the 2016 AANS Annual Scientific Meeting.
This research investigates the role of intraventricular transplantation using bone marrow mesenchymal stem cell in stroke patients.
This study was one group (eight patients) pre- and post-test design. Subjects were selected from supratentorial hemorrhagic stroke patients after six months of treatment with stable neurological deficits with NIHSS of 5–25. Clinical outcomes were measured using the NIHSS scale six months after transplantation. Bone marrow was aspirated, taken from the same patient under aseptic conditions, and expansion of MSC took three to four weeks. All patients were administered a mean of 20 × 106 cells intraventricularly.
The result showed improvement of the NIHSS score in five patients after treatment, and the rest were in the same condition. No important adverse events derived from transplant or surgery was observed during a six-month follow up.
The study demonstrates that bone marrow mesenchymal stem cell can be transplanted intraventricularly with excellent tolerance and without complications. Stem cell transplantation aiming to restore function in stroke is both safe and feasible. Further randomized controlled trials are needed to evaluate efficacy.
Author Block: Asra Al Fauzi, MD, IFAANS; Nur Suroto (Surabaya, Indonesia)
Disclosure: The author reported no conflicts of interest.
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Founded in 1931 as the Harvey Cushing Society, the American Association of Neurological Surgeons (AANS) is a scientific and educational association with more than 10,000 members worldwide. The AANS is dedicated to advancing the specialty of neurological surgery in order to provide the highest quality of neurosurgical care to the public. Fellows of the AANS are board-certified by the American Board of Neurological Surgery, the Royal College of Physicians and Surgeons of Canada or the Mexican Council of Neurological Surgery, A.C. Neurosurgery is the medical specialty concerned with the prevention, diagnosis, treatment and rehabilitation of disorders that affect the spinal column, spinal cord, brain, nervous system and peripheral nerves.
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