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Obesity, Appetite Control, Weight, Endoplasmic Reticulum, Pomc Neurons, Hypothalamus, ERAD

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 19-Feb-2018 4:00 PM EST

Science

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Biology, DNA, Chromosomes, Cell Division, condensin, Cell Biology

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 22-Feb-2018 2:00 PM EST

Science

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Hydrogels, Voltage, soft power, electric eel, Implants, Power, electric organ, Anirvan Guha, Thomas B. H, Schroeder, Aaron Lamoureaux, Gloria Vanrenterghem, David Sept, Max Shtein, Jerry Yang, Michael Mayer, University of Fribourg, University Of Michigan, University of California, San Diego, Biophysical Society 62nd Meeting, Biophysical Society

Electric Eel-Inspired Device Reaches 110 Volts

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In an effort to create a power source for future implantable technologies, a team of researchers developed an electric eel-inspired device that produced 110 volts from gels filled with water, called hydrogels. Their results show potential for a soft power source to draw on a biological system’s chemical energy. Anirvan Guha will present the research during the 62nd Biophysical Society Annual Meeting, Feb. 17-21.

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Science

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Mitosis, cell, Cancer Cells, Cancer, Bayesian, Yeast, spindle pole body, Chromosomes, cell structure, Shruthi Viswanath, Massimiliano Bonomi, Seung Joong Kim, Vadim A. Klenchin, Keenan Taylor, King C. Yabut, Neil T. Umbreit, Janet Meehl, Michele H. Jones, Javier Velazquez-Muriel, Mark Winey, Ivan Rayment, Trisha N. Davis, Andrej Sali, Eric D. Muller, University o

Studying Mitosis’ Structure to Understand the Inside of Cancer Cells

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Cell division is an intricately choreographed ballet of proteins and molecules that divide the cell. During mitosis, microtubule-organizing centers assemble the spindle fibers that separate the copying chromosomes of DNA. While scientists are familiar with MTOCs’ existence and the role they play in cell division, their actual physical structure remains poorly understood. Researchers are now trying to decipher their molecular architecture, and they will present their work during the 62nd Biophysical Society Annual Meeting, held Feb. 17-21.

Science

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Circadian Clock, Circadian, Protein, Biological Clock, Cyanobacteria, Bacteria, biological function, Andy LiWang, University of California, Merced, Biophysical Society 62nd Meeting, Biophysical Society

What Makes Circadian Clocks Tick?

Circadian clocks arose as an adaptation to dramatic swings in daylight hours and temperature caused by the Earth’s rotation, but we still don’t fully understand how they work. During the 62nd Biophysical Society Meeting, held Feb. 17-21, Andy LiWang, University of California, Merced, will present his lab’s work studying the circadian clock of blue-green colored cyanobacteria. LiWang’s group discovered that how the proteins move hour by hour is central to cyanobacteria’s circadian clock function.

Medicine

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Ras protein, Cancer, Cell Membrane, Signaling Pathway, Biophysics, cancer signaling, Oncogene, Stephen G. Sligar, Michael C. Gregory, Mark A. McLean, University of Illinois at Urbana-Champaign, Biophysical Society 62nd Meeting, Biophysical Society

Ras Protein’s Role in Spreading Cancer

Protein systems make up the complex signaling pathways that control whether a cell divides or, in some cases, metastasizes. Ras proteins have long been the focus of cancer research because of their role as “on/off switch” signaling pathways that control cell division and failure to die like healthy cells do. Now, a team of researchers has been able to study precisely how Ras proteins interact with cell membrane surfaces.

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Cryo Electron Microscopy, Direct electron detector

The “Resolution Revolution” Arrives at UAB with Installation of a $600,000 Cryo-Electron Microscope Detector

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Imaging of biomolecules is taking a leap forward at the University of Alabama at Birmingham. UAB installed a $600,000 direct electron detector on its cryo-electron microscope in January, and validation tests to fine-tune the resolution are underway.

Medicine

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Paternal, Development, Neurodevelopment, Autism, Depression, Sperm, genetic, DNA, Epigenetic, Gene Expression, Maternal, Brain Development, Neuroscience, Aaas, AAAS Annual Meeting

New Research: Increased Stress on Fathers Leads to Brain Development Changes in Offspring

New research in mice has found that a father’s stress affects the brain development of his offspring. This stress changes the father’s sperm, which can then alter the brain development of the child. This new research provides a much better understanding of the key role that fathers play in the brain development of offspring.

Medicine

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kidney development

Research Compares Mouse and Human Kidney Development

• Three new research articles compare human and mouse kidney development to identify shared and novel features. • The studies provide new detailed molecular data to guide future research. • The studies revealed deep conservation of certain processes, but also significant differences in gene expression during kidney development, as well as in the timing, scale, organization, and molecular profile of key cell types and cell structures.







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