Chulalongkorn University

“ChulaCov19” Thailand’s First COVID-19 Vaccine Has Been Tested on Humans

17-Jun-2021 8:55 AM EDT, by Chulalongkorn University

On June 14, 2021 at Bhumisirimangalanusorn Building, Chulalongkorn Memorial Hospital, the Thai Red Cross Society, the Faculty of Medicine and the Chula Vaccine Research Center (CVRC), Faculty of Medicine, Chulalongkorn University conducted its first phase of clinical trial on volunteers who have passed the screening process and deemed to be in good health.  The process is continuing on to phase 2 to monitor immunity reactions to the ChulaCov19 vaccine under the supervision of medical experts, doctors, nurses and the research team.

 

                                                      o Professor Suttipong Wacharasindhu, M.D., Director of Chulalongkorn Memorial Hospital, the Thai Red Cross Society and Dean of the Faculty of Medicine

                                                                 Professor Suttipong Wacharasindhu

 

According to Professor Suttipong Wacharasindhu, M.D., Director of Chulalongkorn Memorial Hospital, the Thai Red Cross Society and Dean of the Faculty of Medicine, since the spread of COVID-19 in Thailand Chulalongkorn Memorial Hospital and the Faculty of Medicine, Chulalongkorn University have assured the public that its facilities, personnel and state-of -the-art technology can be used efficiently in the screening and treatment for members of the public.  There is also the Vaccine Research Center of Chula’s Faculty of Medicine, a medical research institution that prides itself on the collaborative efforts of medical researchers and scientists who have worked on developing vaccines to serve the needs of the people both at the national and international levels.  These efforts have reached the stage where the ChulaCov19 vaccine has now been tested in the first phase of clinical trial on a number of volunteers and continued on to the second phase under close supervision of the various sectors involved, along with a team of highly qualified medical practitioners from CVRC.  This is to offer the people the greatest possible confidence in all the phases of the clinical trials.

“We wish to express our appreciation to the Ministry of Public Health, the National Vaccine Institute, CVRC, and several other agencies from the government, the private as well as the public sectors, along with medical researchers of high repute at both the national and international levels.  It is due to their efforts that we have achieved this level of success where we are now ready to manufacture the vaccine and perform clinical trials on participating volunteers.” said the Dean of the Faculty of Medicine. 

 

                                                       Professor Kiat Ruxrungtham, M.D., Director of the CVRC added that the development of the ChulaCov19

                                                                      Professor Kiat Ruxrungtham

 

Professor Kiat Ruxrungtham, M.D., Director of the CVRC added that the development of the ChulaCov 19 was made possible with the support from the government, private and public sectors such as the National Vaccine Institute, the National Research Council of Thailand, Chulalongkorn University’s Second Century Fund, and donations from the Faculty of Medicine Alumni Association’s Vaccine Research Fund, the Red Cross Society of Thailand. 

ChulaCov19 was designed and developed by a team of Thai researchers working collaboratively with Pennsylvania University’s Professor Drew Weissman a physician-scientist renowned for his discovery of the technology used in the production of this vaccine.  We use the tiny particles of the Corona Virus’ genetic material (mRNA) to tell cells to make specific viral proteins such as the spike protein to enter host cells and boost them to build immunity to combat the virus once there is contact with the vaccine.  After this mRNA has performed its role of enabling the body to develop the protein within a few days, the mRNA will disintegrate and not leave any build up in the body whatsoever. 

Prior to this, the CVRC has been successful in its trial on monkeys and mice where it was found to be able to prevent the virus from entering the bloodstream and increased the level of immunity significantly.  This led to the manufacturing and clinical trials in the first phase to volunteers starting on June 14, 2021.  The trial phases are divided into:

The First phase trial is carried out in 72 volunteers from two age groups:  the first group with 36 volunteers aged 18-55 years; the second with 36 volunteers aged 65-75.  Both groups are divided into sub-groups each with a different dosage of 10, 25 and 50 micrograms.  This is to determine the dosage at which the ChulaCov19 shows the greatest efficacy, since at present Moderna’s dosage is 100 micrograms while Pfizer is 30 micrograms.  The CVRC will need to find out whether the dosage for Thais or Asians should be 10, 25 or 50 micrograms in order to ensure safety while increasing immunity levels.  Then the trial will move on to Phase 2.

The second-phase trial is expected to commence around early August 2021 and the number of volunteers will be increased to 150-300 persons. 

“For our vaccine trails, the safety of our volunteers is our greatest concern.  The injections will therefore take time and should be carried out incrementally.  The same standards are applicable throughout the country to determine if the vaccine can really prevent illness and death.  If the World Health Organization (WHO) or the National Institutes of Health (NIH) is able to set the standards of immunity boosting level for a vaccine to be considered efficient” then this should help reduce the process.  For example, if the standard for a quality Covid-19 vaccine is determined as the ability to boost the immunity at higher than 80 IU (international units), if ChulaCov19 can achieve a higher immunity boosting level, then it meets the requirements of efficiency, and can skip the third phase trial and may be given the green light to be manufactured for a large number of people before the middle of next year” Prof. Kiat, M.D. explained.

 

                             Professor Kiat Ruxrungtham, M.D., Director of the CVRC added that the development of the ChulaCov19
                                                       
                                                                  Professor Kiat Ruxrungtham

 
Outstanding qualities of the ChulaCov19 Vaccine

  • Vaccine temperature endurance tests showed that ChulaCov19 could be stored at 2-8 degrees Celsius refrigeration for as long as 3 months and can also be kept at room temperature of 25 degrees Celsius for a period of 2 weeks.  This makes the vaccine much easier to store than other types of mRNA Covid-19 vaccines. 

  • The results of the animal trials have been very good.  The mice that had been modified to have the ability to contract Covid-19 showed that after being fully vaccinated with 2 doses of ChulaCov19 vaccine at 3-week intervals, and exposed to COVID-19 virus via their nose, the rats were prevented from contracting the virus and having the virus entering their bloodstream.  The vaccine also could reduce the level of viruses in the nose and in the lungs by at least 10,000,000 times.  When tested, toxicity was at a safe level.  The mice that did not receive the vaccine would contract Covid-19 within 3-5 days an all of them showed a high level of infection in the bloodstream, in their noses as well as in their lungs. 
     

  • Since there is no need to wait for the virus to be cultured, the mRNA type of vaccine can be manufactured very rapidly.  With the mRNA vaccine, one simply needs to know the variant of the virus to be able to design a vaccine that can be synthesized in a test tube within 4 weeks and able to be tested in mice. With the short manufacturing turnaround, this means there is no need for large scale factories since the synthesis for another vaccine can also take place when the virus mutates. 

             

 

Finally, the CVRC has prepared for animal trials of the second batch of vaccine alongside the aforementioned first batch clinical trials in case of drug resistance or mutations – a matter that is a cause of immense concern all over the world with the emerging variants such as the English, Indian, South African and Brazilian.  The ChulaCov19 vaccine has been designed, developed and manufactured by Thais and enjoys excellent support and collaboration from all relevant sectors. If things proceed as planned, it is hoped that a vaccine capable of preventing mutated and drug resistant variants can be tested on our volunteers by the fourth trimester of this year. 

The volunteers in the project shared their feelings saying that they decided to take part in the project upon hearing the news calling for volunteer applicants on social media.  This was the first day of the trial and they did not feel nervous or anxious since they had been briefed on what to expect and were warmly welcomed by the doctors, nurses and staff who reassured them tremendously.  They said they looked forward to seeing Thailand with a vaccine of its own and felt confident in the potentials of Chula medical doctors who have been able to invent and develop a vaccine that is suitable for Thais.  They ask that the Thai people to put their trust in the potentials of the Thai medical doctor team which is a matter of great pride to all of us to now have a vaccine we can call our own.

 



Filters close

Showing results

110 of 6132
Released: 5-Aug-2021 2:10 PM EDT
Should COVID-19 Vaccination Be Mandatory for Health and Care Staff?
BMJ

Italy, France, and Greece have made covid-19 vaccination mandatory for healthcare workers, and England is making it compulsory for care home workers and consulting on whether to extend this to healthcare workers and other social care staff.

Newswise: Organ Transplant Recipients Significantly Protected by COVID-19 Vaccination
Released: 5-Aug-2021 1:55 PM EDT
Organ Transplant Recipients Significantly Protected by COVID-19 Vaccination
University of California San Diego Health

UC San Diego researchers report that solid organ transplant recipients who were vaccinated experienced an almost 80 percent reduction in the incidence of symptomatic COVID-19 compared to unvaccinated counterparts during the same time.

Newswise: Statement: Employers Need to Require COVID-19 Vaccination for Healthcare Workforce
Released: 5-Aug-2021 1:30 PM EDT
Statement: Employers Need to Require COVID-19 Vaccination for Healthcare Workforce
American Association of Critical-Care Nurses (AACN)

The American Association of Critical-Care Nurses calls for all healthcare and long-term-care employers to require every member of the healthcare team to be vaccinated against COVID-19, except when medically contraindicated.

Newswise: 17d548cf-cfe0-4673
Released: 5-Aug-2021 1:10 PM EDT
Heads Reveal How ‘Overwhelming’ Government Guidance Held Schools Back as COVID Hit
University of Cambridge

Headteachers and school leaders have described how an ‘avalanche’ of confused and shifting Government guidance severely impeded schools during the critical first months of COVID lockdown in a new study.

Released: 5-Aug-2021 10:55 AM EDT
AMSSM Partners with White House and 11 Organizations to Encourage Vaccine Conversations During Sports Physicals
American Medical Society for Sports Medicine (AMSSM)

AMSSM and 11 other leading sports and medical organizations signed on to a consensus statement to encourage healthcare providers to include conversations about COVID-19 vaccinations as part of the pre-participation physical.

Newswise: August Issue of Issue of The American Journal of Gastroenterology Includes Diet-Associated NAFLD Risk and Increased Risk of Mortality from COVID-19 Among PPI Users
Released: 5-Aug-2021 9:25 AM EDT
August Issue of Issue of The American Journal of Gastroenterology Includes Diet-Associated NAFLD Risk and Increased Risk of Mortality from COVID-19 Among PPI Users
American College of Gastroenterology (ACG)

The August issue of The American Journal of Gastroenterology includes clinical discussions of diet-associated NAFLD risk and increased risk of mortality from COVID-19 among PPI users. In addition, this issue features clinical research and reviews on IBS, gender barriers for CRC screening, hepatitis C, eosinophilic esophagitis, and more.

Released: 5-Aug-2021 8:45 AM EDT
Research Reveals that Flu Shot Protects Against Severe Effects of COVID-19
University of Miami Health System, Miller School of Medicine

In a newly published study, physician-scientists at the University of Miami Miller School of Medicine have shown that the flu vaccine may provide vital protection against COVID-19.

Released: 5-Aug-2021 8:45 AM EDT
Persistent COVID-19 Infections in Immunocompromised People May Give Rise to Variants of Concern
Fred Hutchinson Cancer Research Center

In an article in the New England Journal of Medicine, scientists from Fred Hutchinson Cancer Research Center, Johns Hopkins Bloomberg School of Medicine, the U.S. Military HIV Research Program and the Institute for Global Health and Infectious Diseases at the University of North Carolina urged increased attention to persistent COVID-19 infections in immunocompromised people.

Newswise: Novel Model Predicts COVID-19 Outbreak Two Weeks Ahead of Time
Released: 5-Aug-2021 8:30 AM EDT
Novel Model Predicts COVID-19 Outbreak Two Weeks Ahead of Time
Florida Atlantic University

People’s social behavior, reflected in their mobility data, is providing scientists with a way to forecast the spread of COVID-19 nationwide at the county level. Researchers have developed the first data-driven deep learning model with the potential to predict an outbreak in COVID-19 cases two weeks in advance. Feeding the mobility data to epidemiological forecasting models helps to estimate COVID-19 growth as well as evaluating the effects of government policies such as mandating masks on the spread of COVID-19.

Released: 4-Aug-2021 5:05 PM EDT
Canadian-Led International Study: Full-Dose Blood Thinners Benefit Moderately Ill COVID-19 Patients
University of Manitoba

The investigators discovered that in moderately ill patients full-dose heparin reduced the need for organ support compared to those who received lower-dose heparin.


Showing results

110 of 6132

close
6.43566