Newswise — BOSTON, NEW YORK, SECAUCUS, NJ- Nov. 16, 2020– Today, Dana-Farber Cancer Institute, one of the world’s leading centers of cancer research and treatment, and Quest Diagnostics, (NYSE: DGX), the world’s leading provider of diagnostic information services, announced the start of a new research study that provides free COVID-19 antibody testing to individuals who are at high risk of developing multiple myeloma.

 The Immune Profiling with Antibody-based COVID-19 Testing (IMPACT) study will investigate the short and long-term impact of COVID-19 of a population who is at risk of developing myeloma or who has a precursor condition to myeloma. This population may be more susceptible to complications after exposure to the virus that causes COVID-19 or during recovery from the disease.  Precursor conditions for multiple myeloma include monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma.

 Through this collaboration, Quest Diagnostics will perform SARS-CoV-2 (COVID-19) IgG antibody testing at no cost to study participants through an in-kind donation to Dana-Farber.

  “Quest Diagnostics is committed to understanding and exploring risk factors for COVID-19 and providing critical diagnostic insights that can help improve care,” said Yuri A. Fesko, MD, Senior Medical Director, Oncology, Quest Diagnostics. “Our research with Dana-Farber Cancer Institute will improve scientific understanding of the unique health challenges facing patients at heightened risk for multiple myeloma and COVID-19 and potential paths to improve their care.”

 According to Irene Ghobrial, MD, clinical investigator and senior physician at Dana-Farber Cancer Institute and Professor of Medicine at Harvard School of Medicine, the goal of IMPACT is to understand what happens to the immune system in patients with multiple myeloma precursor conditions with COVID-19 infection.

 “We ask whether those patients have a different immune system compared to healthy people in a large prospective cohort study,” said  Ghobrial on IMPACT. “We look at antibody levels and changes in immune cells over one year of follow up, while also examining risk factors such as race, obesity, age, and stem cell mutations to rapidly inform the community on risk factors of worse outcome to COVID-19 infection and  response to therapy, including vaccination.”

 Multiple myeloma is not a common cancer, but it is the second most common blood cancer diagnosis, after non-Hodgkin lymphoma, in the United States.1 Multiple myeloma is difficult to diagnose early due to symptoms appearing at an advanced stage.

Currently, there are an estimated 12 million people who have MGUS and smoldering multiple myeloma.2 Because medical professionals do not look for this disease during a routine wellness visit or screen for this blood cancer, many people are unaware they have or are prone to developing the precursor conditions. According to Ghobrial, African Americans are even more severely affected by COVID-19, which may cause immune suppression.

Antibodies developed by the body in response to a viral infection may provide potential immunity against future infection. According to the U.S. Food and Drug Administration, COVID-19 antibody testing may indicate that a “person has been exposed to the virus and developed antibodies against it, which may mean that person has at least some immunity to the coronavirus." Antibody testing uses blood serum specimens and is sometimes referred to as serology testing.

 With the COVID-19 pandemic, there is no test currently in place to detect how a patient with MGUS and smoldering myeloma will respond to COVID-19 and a vaccine. IMPACT was created to provide answers to what happens to these patients when infected by COVID-19. The investigators will study 1) how will these individuals be affected by the virus and will they get affected at higher rates, 2) how severe is the prognosis, 3) what is the long term immune response after infection in patients with precursor blood cancer compared to healthy individuals, 4) what is the long term response after vaccination.  

 “This study is critical to arm medical professionals with important information and guidance on how to proceed when treating patients with MGUS and smoldering multiple myeloma during the pandemic,” said Ghobrial.

 Research shows that multiple myeloma, its precursor conditions, and COVID-19 disproportionately affect African Americans compared to White individuals. However, little is known about how exposure to the virus that causes COVID-19 may influence risk of developing multiple myeloma in the future or the severity of the disease if it does occur. IMPACT is the first research study designed to answer these questions.

 “Plasma cells secrete antibodies and antibodies are the first line of attack against COVID-19.  By definition if you have MGUS and smoldering multiple myeloma, and you have a plasma cell problems, then you will have an issue where the immune system will be suppressed,” said Ghobrial. “We do not know how the immune system will respond to a COVID-19 infection in these patients, how the patients will respond to a vaccine when it eventually becomes available, and what is the long term immunity of these patients in response to COVID-19 or to a vaccine.”

 This study requires participants to be enrolled for one year, and if positive for the presence of COVID-19 antibodies, provide blood samples every three months during this one-year period.

 Participants must be part of either the PROMISE or PCROWD studies. The PROMISE study is a screening study that aims to enroll and screen for multiple myeloma or its precursor conditions but have not already been diagnosed with these conditions. The PCROWD study, a sister study for people with precursor conditions, is for adults who have been diagnosed with MGUS, smoldering multiple myeloma, or Waldenstrӧm Macroglobulinemia.

For more information, please visit and sign up for the free screening at or call 617-582-8544.





About Dana-Farber Cancer Institute

Dana-Farber Cancer Institute is one of the world’s leading centers of cancer research and treatment. Dana-Farber’s mission is to reduce the burden of cancer through scientific inquiry, clinical care, education, community engagement, and advocacy. We provide the latest treatments in cancer for adults through Dana-Farber/Brigham and Women’s Cancer Center and for children through Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. Dana-Farber is the only hospital nationwide with a top 10 U.S. News & World Report Best Cancer Hospital ranking in both adult and pediatric care.

 As a global leader in oncology, Dana-Farber is dedicated to a unique and equal balance between cancer research and care, translating the results of discovery into new treatments for patients locally and around the world, offering more than 1,100 clinical trials. 

 About COVID-19 Testing by Quest Diagnostics Quest Diagnostics is at the forefront of the response to the COVID-19 pandemic, working to broaden access to laboratory insights to help us all lead healthier lives. We provide both molecular and antibody tests for diagnosing COVID-19 and identifying past infections. Our COVID-19 molecular and antibody tests are FDA approved and meet our high standards for quality. We are providing these test services under the Public Readiness and Emergency Preparedness Act. We provide data on COVID-19 testing to various federal and state public health authorities, including the Centers for Disease Control and Prevention, and participate in studies with government and private institutions, aiding COVID-19 public health response and research. Through our team of dedicated phlebotomists, air fleet team, couriers and laboratory professionals, Quest Diagnostics works hard every day to help patients and communities across the United States access quality COVID-19 testing. For the latest updates and digital assets about Quest Diagnostics COVID-19 testing, visit:


About Quest Diagnostics

Quest Diagnostics empowers people to take action to improve health outcomes. Derived from the world's largest database of clinical lab results, our diagnostic insights reveal new avenues to identify and treat disease, inspire healthy behaviors and improve health care management. Quest annually serves one in three adult Americans and half the physicians and hospitals in the United States, and our 47,000 employees understand that, in the right hands and with the right context, our diagnostic insights can inspire actions that transform lives.