Hydroxychloroquine could be useful treatment of COVID-19, but more clinical studies needed

American Physiological Society (APS)
30-Jul-2020 11:05 AM EDT, by American Physiological Society (APS)

Research Alert

The role of ACE2 in the action of Chloroquine (CQ) and hydroxychloroquine (HCQ) needs to be further studied. Based on the existing studies, CQ/HCQ may be potential drugs for treatment of COVID-19 and other ACE2-related virus infections. However, the use of CQ/HCQ should be dealt with cautiously and careful monitoring of potential cardiotoxicity is required in clinical practice and research. The use of high doses and long-term CQ/HCQ treatment require particular care and serious consideration.

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Newswise: Coronavirus Drug for Cats Has Potential Use for COVID-19 Virus in Humans
28-Jul-2020 9:50 AM EDT
Coronavirus Drug for Cats Has Potential Use for COVID-19 Virus in Humans
American Crystallographic Association (ACA)

Researchers at the University of Alberta say a protease in SARS-CoV-2 can be targeted with a drug that is also used to treat feline infectious peritonitis, a fatal infection in cats caused by a coronavirus. The drugs, dipeptide-based protein inhibitors, could be used to slow or stop replication of the COVID-19 virus in humans. During the 70th annual meeting of the American Crystallographic Association, Joanne Lemieux will outline how the drugs are strong candidates for the treatment of human coronavirus infections.

Released: 4-Aug-2020 1:40 PM EDT
Tip Sheet: COVID-19 vaccines, COVID-19 and cancer patients, smoking cessation apps, structural racism in medicine – and more
Fred Hutchinson Cancer Research Center

Summaries of recent Fred Hutch research findings and other news with links for additional background and media contacts.

Newswise: Story Tips: Pandemic impact, root studies, neutrons confirm, lab on a crystal and modeling fusion
Released: 4-Aug-2020 1:25 PM EDT
Story Tips: Pandemic impact, root studies, neutrons confirm, lab on a crystal and modeling fusion
Oak Ridge National Laboratory

ORNL Story Tips: Pandemic impact, root studies, neutrons confirm, lab on a crystal and modeling fusion

Newswise: How Countries Are Reopening Schools During the Pandemic
Released: 4-Aug-2020 1:20 PM EDT
How Countries Are Reopening Schools During the Pandemic
Council on Foreign Relations (CFR)

Educators worldwide are facing the agonizing decision of whether to resume in-person instruction while there’s still no cure for the new coronavirus. Countries including Denmark, India, and Kenya are taking different approaches.

Released: 4-Aug-2020 11:55 AM EDT
ACTG Announces Launch of Novel Clinical Trial Testing Multiple Therapeutics to Treat COVID-19
University of California, Los Angeles (UCLA), Health Sciences

The AIDS Clinical Trials Group (ACTG) has initiated the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial. ACTIV-2 includes both phase 2 and phase 3 evaluations of multiple promising investigational agents for treating early COVID-19 in a single trial.

Newswise:Video Embedded covid-19-study-confirms-low-transmission-in-educational-settings2
VIDEO
Released: 4-Aug-2020 11:20 AM EDT
COVID-19 study confirms low transmission in educational settings
University of Sydney

The rate of COVID-19 transmission in New South Wales (NSW) educational settings was extremely limited during the first wave of COVID-19, research findings published today in The Lancet Journal of Child and Adolescent Health have shown.

Newswise: Droplet Spread from Humans Doesn’t Always Follow Airflow
31-Jul-2020 3:15 PM EDT
Droplet Spread from Humans Doesn’t Always Follow Airflow
American Institute of Physics (AIP)

If aerosol transmission of COVID-19 is confirmed to be significant, as suspected, we will need to reconsider guidelines on social distancing, ventilation systems and shared spaces. Researchers in the U.K. believe a better understanding of different droplet behaviors and their different dispersion mechanisms is also needed. In Physics of Fluids, the group presents a model that demarcates differently sized droplets. This has implications for understanding the spread of airborne diseases, because the dispersion tests revealed the absence of intermediate-sized droplets.

Released: 4-Aug-2020 10:30 AM EDT
COVID-19 study confirms low transmission in educational settings
University of Sydney

The rate of COVID-19 transmission in New South Wales (NSW) educational settings was extremely limited during the first wave of COVID-19, research findings published today in The Lancet Journal of Child and Adolescent Health have shown.

Newswise: Researchers develop new mouse model for SARS-CoV-2
Released: 4-Aug-2020 10:00 AM EDT
Researchers develop new mouse model for SARS-CoV-2
The Rockefeller University Press

Researchers at Yale University School of Medicine have developed a new mouse model to study SARS-CoV-2 infection and disease and to accelerate testing of novel treatments and vaccines against the novel coronavirus. The study, published today in the Journal of Experimental Medicine (JEM), also suggests that, rather than protecting the lungs, key antiviral signaling proteins may actually cause much of the tissue damage associated with COVID-19.


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