3D-Printed 'Hyperelastic Bone' May Help Generate New Bone for Skull Reconstruction


Newswise — May 16, 2019Defects of the skull and facial bones can pose difficult challenges for plastic and reconstructive surgeons. A synthetic material called hyperelastic bone – readily produced by 3D-printing – could offer a powerful new tool for use in reconstructing skull defects, reports a study in the May issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

The experimental material accelerates bone regeneration across skull defects in rats, according to initial results by Ramille N. Shah, PhD, and colleagues of Northwestern University and University of Illinois Health, Chicago. The researchers write, "Hyperelastic bone has significant potential to be translated to craniofacial reconstructive surgery, where the need for cost-effective bone replacement grafts is enormous."

Promising New 3D-Printed Bone Replacement for Skull Reconstruction

The researchers report initial experiments with hyperelastic bone in rats with surgically created defects of the top of the skull. The surgically created defects were of a "critical size" unlikely to heal on their own – similar to those seen in patients who have undergone surgery for brain tumors.

Hyperelastic bone is a "3D-printed synthetic scaffold," consisting mainly of bone mineral (hydroxyapatite) plus a widely used, biocompatible material (polyglycolic acid). Hyperelastic bone consists of an intricate latticework, designed to support the growth and regeneration of new bone. It[TO1]  can be quickly and inexpensively produced using current 3D printing hardware platforms and is malleable enough to be press-fit or cut into shape during surgery.

In the experiments, some cranial defects were reconstructed using hyperelastic bone and others using the animal's own (autologous) bone. Autologous bone is the preferred material for reconstructing bone defects, but can be difficult to obtain – requiring bone to be taken from a "donor site" elsewhere in the body – and sometimes isn't available at all. In other animals, reconstruction was performed using a scaffold made of polyglycolic acid only, without bone mineral.

The 3D-printed hyperelastic bone provided good bone regeneration. On follow-up CT scans, hyperelastic bone was about 74 percent effective after eight weeks and 65 percent at 12 weeks, compared to autologous bone. In contrast, defects treated with the polyglycolic acid scaffold showed little new bone formation.

Microscopic examination showed that the hyperelastic bone scaffold was gradually surrounded first by fibrous tissue, then by new bone cells. Over time, the scaffold would be gradually replaced completely by new bone, incorporating the implanted bone mineral.

"Hyperelastic bone has significant potential to be translated to craniofacial reconstructive surgery, where the need for cost-effective bone replacement grafts is enormous," Dr. Shah and colleagues conclude. With further development, they believe this 3D-printed material may provide a valuable alternative to autologous bone and commercially available bone substitutes.

"Our study underscores the promising translational potential of this novel strategy for tissue engineering applications, particularly bone regeneration," the researchers add. They emphasize that further experimental studies will be needed to confirm the use of hyperelastic bone for specific types of craniofacial reconstruction.

Click here to read "Three-Dimensionally Printed Hyperelastic Bone Scaffolds Accelerate Bone Regeneration in Critical-Size Calvarial Bone Defects"

DOI:10.1097/PRS.0000000000005530

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Plastic and Reconstructive Surgery® is published in the Lippincott portfolio by Wolters Kluwer.

About Plastic and Reconstructive Surgery

For more than 70 years, Plastic and Reconstructive Surgery® (http://www.prsjournal.com/) has been the one consistently excellent reference for every specialist who uses plastic surgery techniques or works in conjunction with a plastic surgeon. The official journal of the American Society of Plastic Surgeons, Plastic and Reconstructive Surgery® brings subscribers up-to-the-minute reports on the latest techniques and follow-up for all areas of plastic and reconstructive surgery, including breast reconstruction, experimental studies, maxillofacial reconstruction, hand and microsurgery, burn repair and cosmetic surgery, as well as news on medico-legal issues.

 About ASPS

The American Society of Plastic Surgeons is the largest organization of board-certified plastic surgeons in the world. Representing more than 7,000 physician members, the society is recognized as a leading authority and information source on cosmetic and reconstructive plastic surgery. ASPS comprises more than 94 percent of all board-certified plastic surgeons in the United States. Founded in 1931, the society represents physicians certified by The American Board of Plastic Surgery or The Royal College of Physicians and Surgeons of Canada.

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