A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling

Newswise — Throughout an organism’s life, the activity of niche signals fluctuates due to injury, and stem cells need to respond accordingly. Klein and colleagues found that during high Wnt activity observed in intestinal regeneration, niche canonical WNT ligands activate non-canonical Wnt signaling via a DLG1-ARHGAP31-CDC42 axis required for stem cell-driven regeneration.