Focus: Cancer Center Featured Story 2

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Cancer health disparities are often identified from population-based surveillance data routinely captured by statewide cancer registries. Antoinette Stroup, PhD, of Rutgers Cancer Institute of New Jersey, New Jersey’s only National Cancer Institute – Designated Comprehensive Cancer Center together with RWJBarnabas Health and Rutgers School of Public Health is the director of the New Jersey State Cancer Registry (NJSCR), explores cancer and health data on the Asian American and Pacific Islander population.

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Investigators from Rutgers Cancer Institute of New Jersey, New Jersey’s only National Cancer Institute- Designated Comprehensive Cancer Center, led a collaborative study to examine the patterns of druggable oncogenic fusions in colon cancer specimens including microsatellite-stable and unstable (MSI) tumors.

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A study by UC Davis and UC San Francisco identified multiple barriers that family physicians navigate to provide abortion services to their patients. The barriers include lack of physician training and federal, state and institutional restrictions on providing medication abortion.

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Current discoveries include a novel target for mutant colorectal cancers, advances in breast cancer metastases to the brain and bone, a new understanding for secondary leukemias, biomarkers for myelofibrosis treatment response, a computational tool for combining single-cell datasets, unique immune features of pre-cancerous pancreatic cysts, encouraging clinical results for Ewing sarcoma and a new protein critical for T cells to mount an anti-tumor immune response.

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In a new study featured on the cover of the May 1 issue of the journal Cancer Research, Moffitt Cancer Center researchers report on their identification of biomarkers based on a type of genetic modification called methylation that predicts the type of tumor immune environment and patient outcomes.

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UC Davis Health physicians have performed the first single anesthesia diagnosis to treatment of lung cancer utilizing a fully robotic approach in the UC Health System. Procedure allows physicians to diagnose and remove lung cancer mass during single surgery.

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Dana-Farber Cancer Institute names new Senior Vice President, General Counsel and Chief Governance Officer

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Adolescent and young adult survivors of acute lymphoblastic leukemia and acute myeloid leukemia, two of the most common leukemias for ages 15 to 39 years old, have increased risk of mortality than the general population for decades after initial diagnosis. Researchers investigated disparities specific to survivorship to learn about patients’ outcomes after they survived their initial diagnosis; and analyzed data from cancer survivors who were at least five years post treatment. Results suggest there is a gap in critical data surveillance that needs to be examined to further understand what is impacting long-term survivorship for AYAs.

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A new study in JNCCN finds patients with cancer who smoke are more likely to receive evidence-based cessation assistance by using the ELEVATE program, increasing the likelihood of better outcomes.

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A study led by UC Davis Cancer Center identified a binding protein in cancer cell’s nucleus, known as CHD4, as a critical agent keeping Kaposi's sarcoma-associated herpesvirus (KSHV) dormant and undetected by the body’s immune system. CHD4 is linked to cancer cell growth in many types of cancers.

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About 95% of participants achieved a measurable immune response after vaccination, according to study published in JAMA Oncology.

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Though the mutations accumulated by cancer cells occur more or less randomly, certain regions of genes essential to cancer growth appear to be more frequently mutated than others in established tumors.

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Memorial Sloan Kettering Cancer Center (MSK) and the Robbins Family Foundation are proud to announce today that 13 distinguished MSK nurses and one nursing team were recognized with the 2022 Robbins Family Award for Nursing Excellence. During National Nurses Week (May 6 – 12), MSK recognizes outstanding nurses for exemplary service.

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Two nurses are named recipients of Rutgers Cancer Institute’s ‘Oncology Nursing Excellence Awards’ during Nurses Week each year. This year’s award recipients were named during the annual Elizabeth Gibby Osborne Lecture today.

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A phase 2 clinical trial testing novel immunotherapy combinations in aggressive ovarian cancer has opened and first patients have begun treatment.

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In a new study published in the journal Cell Reports, Moffitt Cancer Center researchers show that cancer cells in an acidic environment undergo lipid synthesis and accumulation. The team identified the key signaling molecules responsible for these changes and discovered that these alterations are associated with poor outcomes and disease progression among breast cancer patients.

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In a study led by Dr. Lajos Pusztai, Professor of Medicine (Medical Oncology) at Yale Cancer Center, researchers across various institutions, and on behalf of the I-SPY consortium, developed a novel continuous residual cancer based metric to compare neoadjuvant chemotherapy efficacy between randomized trial arms in preoperative breast cancer trials.

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New research from Yale Cancer Center provides a new understanding of patients’ views of artificial intelligence (AI) in health care. W

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Researchers in the Center of Excellence for Evolutionary Therapy at Moffitt Cancer Center have been investigating an alternative treatment approach called adaptive therapy that focuses on maintaining disease control instead of complete tumor cell elimination. In a new study published in Communications Medicine, the researchers used mathematical modeling to reveal that the spatial organization of a tumor is an important factor that governs how cells compete with one another and the effectiveness of adaptive therapy.

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Researchers at The University of Texas MD Anderson Cancer Center have identified a novel strategy to reduce immune-related adverse events from immunotherapy treatment by targeting the cytokine interleukin-6 (IL-6).

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SEATTLE — May 4, 2022 — Below are summaries of recent Fred Hutchinson Cancer Research Center research findings and other news.

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Featured studies include clinical advances with a new combination therapy targeting angiogenesis in platinum-resistant ovarian cancer and a promising immunotherapy combination for kidney cancer, plus laboratory studies that focus on targeting ferroptosis in specific lung cancers, developing chimeric antigen receptor (CAR) T cell therapies for blastic plasmacytoid dendritic cell neoplasms, and characterizing racial and ethnic disparities in breast cancer early detection.

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In a new study published in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research, Moffitt Cancer Center researchers share the identification of a new potential target for CAR T cells called OR2H1 that they have demonstrated inhibits growth in lung and ovarian tumors

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The Association of American Cancer Institutes (AACI) welcomes its newest member, the Koch Institute for Integrative Cancer Research at MIT.

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To highlight the importance of lifesaving cancer research, National Cancer Research Month, led by the American Association for Cancer Research (AACR), is recognized during May. Rutgers Cancer Institute of New Jersey together with RWJBarnabas Health, the state’s only National Cancer Institute-designated Comprehensive Cancer Center, has curated a selection of ongoing research focusing on cancer disparities which features members from the Cancer Health Equity Center of Excellence.

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Saum Ghodoussipour, MD, urologic oncologist and director of the Bladder and Urothelial Cancer Program at Rutgers Cancer Institute and assistant professor of surgery at Rutgers Robert Wood Johnson Medical School, shares more on bladder health.

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Joseph P. Weiner, MD, radiation oncologist at Rutgers Cancer Institute and assistant professor of radiation oncology at Rutgers Robert Wood Johnson Medical School, who specializes in malignant and benign cancers of the brain and spine shares more about Gamma knife, a non-surgical treatment option that uses high doses of precisely focused radiation beams to destroy cancer cells and non-cancerous tumors.

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Carolyn J. Heckman, PhD, co-leader of the Cancer Prevention and Control Program at Rutgers Cancer Institute and an associate professor of medicine at Rutgers Robert Wood Johnson Medical School, is corresponding author and shares more on unburns and sun protection behaviors among male Hispanic outdoor day laborers in the Northeast U.S.

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Sarah Weiss, MD, medical oncologist at Rutgers Cancer Institute of New Jersey and associate professor of medicine at Rutgers Robert Wood Johnson Medical School, answers questions about skin cancer and sun protection that you may be wondering

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Several nursing teams from Roswell Park Comprehensive Cancer Center were invited to share their research at the 47th Annual Congress of the Oncology Nursing Society (ONS), which is underway in Anaheim, California, and continues through May 1, 2022.

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The University of Texas MD Anderson Cancer Center and Indianapolis-based Community Health Network today announced a partnership agreement to create Community Health Network MD Anderson Cancer Center. A comprehensive clinical and research cancer program collaboration in central Indiana, Community MD Anderson will provide Hoosier cancer patients greater access to some of the most advanced oncology care.

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Moffitt Cancer Center researchers are working to improve the ability to identify patients who are at a higher risk of poor survival through radiomics, an area of science that uses imaging, such as CT scans and MRIs, to uncover tumoral patterns and characteristics that may not be easy to spot by the naked eye. Results of their newest study was published today in Cancer Biomarkers.

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National Comprehensive Cancer Network Advisory Committee on COVID-19 Vaccination and Pre-exposure Prophylaxis provides expert consensus to help guide cancer care providers on latest research, available at NCCN.org/covid-19.

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Bladder cancer affects nearly 84,000 people in the United States each year, making it the sixth most common cancer. Most people survive it, but unfortunately, many lose their bladders. Neda Hashemi, MD, and her team at The University of New Mexico Comprehensive Cancer Center are now offering several clinical trials, including one that will give people with bladder cancer a chance to fight their disease and keep their bladders.

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Oncology Nurses from Rutgers Cancer Institute of New Jersey together with RWJBarnabas Health will be presenting at the Oncology Nursing Society’s (ONS) 47th Annual Congress being held April 27 to May 1 in Anaheim, California.

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UC Davis Comprehensive Cancer Center has launched the Center for Advancing Cancer Health Equity. The new center will work to improve health outcomes in underserved populations and help shape cancer-related policy decisions at the county, state, and national levels.

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The phase 2 clinical trial of a multi-center study known as the COAST clinical trial has demonstrated improved outcomes using immunotherapy combinations for patients with unresectable stage III non-small cell lung cancer, according to researchers at Yale Cancer Center and participating organizations.

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National Comprehensive Cancer Network’s Oncology Research Program to oversee projects from early-career investigators advancing key areas for study in cancer care and biology, such as novel combination therapy, equitable access to cellular therapies, immune cell dysfunction, liquid biomarkers, genetic ancestry, oncogenic vulnerabilities, and MAIT cell antitumor activity.

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The American Cancer Society has awarded Rutgers Cancer Institute $60,000 in patient transportation and lodging grants, which will help alleviate the financial burden of transportation and lodging costs for cancer patients.

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oswell Park Comprehensive Cancer Center specialists will share the latest advances and developments in the treatment of blood-related cancers at the 2022 Tandem Transplantation & Cellular Therapy Meetings of American Society for Transplantation and Cellular Therapy (ASTCT) and Center for International Blood and Marrow Transplant Research (CIBMTR) in Salt Lake City, Utah, from April 23 to 26.

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The University at Buffalo will lead a $10 million project to develop software that academia, industry and government agencies use to manage high-performance computing infrastructure, the U.S. National Science Foundation (NSF) announced on Friday.

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A new initiative called Pluralist will challenge the current paradigm and pursue equity in organ transplantation. The effort will place particular emphasis on communities of color in Sacramento and throughout California by using education intervention tools like social networks and digital media.

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Rutgers Cancer Institute of New Jersey and RWJBarnabas Health have appointed Ira Braunschweig, MD, as chief, Section of Transplant and Cell Therapy at Rutgers Cancer Institute, chief of the Transplant and Cell Therapy Service of the RWJBarnabas Health Oncology Service Line, and director for Cell Therapy and Bone Marrow Transplantation at Robert Wood Johnson University Hospital, an RWJBarnabas facility.

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Racism facing Asian Americans is compounding existing cancer inequities. They are the first U.S. population group to experience cancer as the leading cause of death. A commentary in the Journal of the American Cancer Institute outlines the factors contributing to this.

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Memorial Sloan Kettering Cancer Center (MSK) today announced the establishment of The Starr Foundation Program for Discovery Science, a pioneering new initiative made possible by a generous $50 million gift from The Starr Foundation.

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MD Anderson awarded more than $10 million in grants to support collaborative research teams working to advance novel interception and treatment strategies that will improve outcomes for several cancer types with the greatest unmet need, including pancreatic cancer, ovarian cancer and glioblastoma (GBM).

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With all that the Land of Enchantment has to offer, skin cancer isn’t on the top on anyone’s list. But abundant sunshine and a dearth of dermatologists in the state pose a challenge for detecting and treating the various forms of skin cancer. Skin Cancer Screening clinics are now resuming. The first of several new clinics will be held in Albuquerque on Saturday, May 7. More are planned over the coming year in Gallup, Taos and southern New Mexico.

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With all that the Land of Enchantment has to offer, skin cancer isn’t on the top on anyone’s list. But abundant sunshine and a dearth of dermatologists in the state pose a challenge for detecting and treating the various forms of skin cancer. Skin Cancer Screening clinics are now resuming. The first of several new clinics will be held in Albuquerque on Saturday, May 7. More are planned over the coming year in Gallup, Taos and southern New Mexico.

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Following an analysis of over 12,000 human genes, research from Yale Cancer Center indicates there is cancer-relevant importance in a much larger proportion of human genes than current cancer research models suggest.