1) Pyridorin, a vitamin B6 derivative, may help slow or prevent the progression of mild kidney disease in some patients with diabetes. 2) The drug does not appear to help diabetics with more advanced kidney disease. 3) The prevalence of type 2 diabetes is expected to double by 2030. Kidney disease cases are sure to rise in parallel.
1) Suloxdexide is no better than placebo at preventing kidney failure or reducing urinary protein excretion in diabetes patients with kidney failure. 2) Kidney disease due to diabetes is the most common cause of kidney failure in developed countries. 3) The prevalence of type 2 diabetes is expected to double by 2030. Kidney disease cases are sure to rise in parallel.
Researchers tested the effectiveness of lenvatinib in patients with advanced, progressive differentiated thyroid cancer (DTC) that does not respond to conventional radioiodine therapy. Data demonstrated a partial response in 45%-50% of the 58 patients enrolled in the study.
A drug treatment has been proven to prevent lesions from cerebral cavernous malformation — a brain blood vessel abnormality that can cause bleeding, epilepsy and stroke — for the first time in a new study. Fasudil shows potential as a valuable new tool in addressing a clinical problem that is currently treatable only with complex surgery.
– Individuals with advanced papillary thyroid cancer (PTC) that are associated with the BRAFV600E gene mutation have a higher risk of recurrent disease and progression to more advanced, poorly differentiated thyroid cancer, according to data presented today at the 81st Annual Meeting of the American Thyroid Association (ATA).
Closer follow-up and recognizing at-risk patients may improve cardiac and colorectal procedure results
New method shows promise in eliminating the need for long-term anti-rejection drugs, particularly for hand and face transplants.
In a development that sheds new light on the pathology of Alzheimer’s disease (AD), Whitehead Institute scientists have identified connections between genetic risk factors for the disease and the effects of a peptide toxic to nerve cells in the brains of AD patients.
Dana-Farber scientists have devised a test that can predict how effective chemotherapy will be by determining whether tumor cells are "primed" for death. The discovery suggests it may be possible to predict which patients will likely benefit from chemo, as well as to make some chemo more effective.
Scientists outline new methods for better understanding links between specific proteins and the risks associated with Alzheimer’s disease in an article co-authored by University of Alabama researchers and publishing today in Science Express.
Identification of three fatty acids involved in the extreme growth of Burmese pythons’ hearts following large meals could prove beneficial in treating diseased human hearts, according to research co-authored by a University of Alabama scientist and publishing in the Oct. 28 issue of Science.
Robert Linhardt is working to forever change the way some of the most widely used drugs in the world are manufactured. Today, in the journal Science, he and his partner in the research, Jian Liu, have announced an important step toward making this a reality. The discovery appears in the October 28, 2011 edition of the journal Science in a paper titled “chemoenzymatic synthesis of homogeneous ultra-low molecular weight heparins.”
People who use over-the-counter “thyroid support’’ supplements may be putting their health at risk, according to a study being presented at the annual meeting of the American Thyroid Association.
Whitehead Institute scientists have determined that master transcription factors determine the genes regulated by key signaling pathways. By manipulating these pathways, scientists may find new ways to treat cancer and other diseases.
A new analysis of Hubble surveys, combined with simulations of galaxy interactions, reveals that the merger rate of galaxies over the last 8 billion to 9 billion years falls between the previous estimates.
A recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM) found that higher levels of testosterone were associated with reduced loss of lean muscle mass in older men, especially in those who were losing weight. In these men, higher testosterone levels were also associated with less loss of lower body strength.
A recent study has found that a childhood behavioral intervention to lower dietary intake of total fat and saturated fat and increase consumption of foods that are good sources of dietary fiber resulted in significantly lower fasting plasma glucose levels and lower systolic blood pressure when study participants were re-evaluated in young adulthood. The study was accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology and Metabolism (JCEM).
Slower walking speed may indicate increased risk of postoperative complications and longer length of hospital stay
A large, international clinical trial led by doctors at the University of California, San Francisco indicates that a vaccine to prevent anal cancer is safe and effective, according to a study reported in the October 27, 2011 issue of New England Journal of Medicine.
Study shows EVAR results can be similar if the technology is affordable and available.
New study finds no change in complications and death rates in major operations when quality care variables provide framework for pay-for-performance programs
Delivering anticancer drugs into breast ducts via the nipple is highly effective in animal models of early breast cancer, and has no major side effects in human patients, according to a report by Johns Hopkins Kimmel Cancer Center researchers in Science Translational Medicine on October 26. The results of the study are expected to lead to more advanced clinical trials of so-called intraductal treatment for early breast cancer.
In a trial that included more than 150,000 participants, those who underwent annual chest radiographic screening for up to 4 years did not have a significantly lower rate of death from lung cancer compared to participants who were not screened, according to a study in the November 2 issue of JAMA.
Thomas Jefferson University Hospital surgeons found that a carefully-selected surgical care check list of 12 measures reduced Whipple procedure wound infections by nearly 50 percent.
Two Fellows of the American College of Surgeons have been honored for surgical volunteerism.
Preschool children with relatively poor language skills improve more if they are placed in classrooms with high-achieving students, a new study found.
Patients with certain genes or specific factors related to use of the anti-clotting drug clopidogrel are more likely to experience a blood clot within a coronary stent shortly after placement, according to a study in the October 26 issue of JAMA.
Among men who were current or former heavy smokers, undergoing lung cancer screening with computed tomography (CT) scanning identified a substantial proportion who had chronic obstructive pulmonary disease (COPD), suggesting that this method may be helpful as an additional tool in detecting COPD, according to a study in the October 26 issue of JAMA.
In a first-of-its-kind study, researchers from Mount Sinai School of Medicine have discovered several gene variants contributing to early stent thrombosis (ST), a devastating and often deadly complication after coronary stent implantation in people with coronary artery disease.
New findings show an increase in postmastectomy breast reconstruction, and that TRAM flap reconstruction remains intact with a high degree of patient satisfaction
New research suggests that infections caused by multi-drug resistant pathogens are not associated with overall, all-cause mortality in the surgical intensive care unit.
Raman spectroscopy technique may lead to more effective treatment for patients with staph infections.
Groundbreaking study marks the first time researchers are able to freeze organoid units and successfully implant at a later date.
A simple blood test could someday quantify a smoker’s lung toxicity and danger of heart disease, researchers at UT Southwestern Medical Center have found.
New research from the University of North Carolina at Chapel Hill shows that obesity may make annual flu shots less effective.
Injectable substance made with proteins enables tissue to grow new blood vessels.
1) Indoor tanning use increased risk for three common skin cancers. 2) Risk increased 11 percent to 15 percent with use every four times per year. 3) Risk effect was more predominant during high school/college.
1) A significantly inverse association was found for coffee consumption and basal cell carcinoma. 2) Decaffeinated coffee consumption was not associated with decreased risk. 3) Coffee consumption was not related to squamous cell carcinoma and melanoma.
1) Use of aspirin was not associated with risk for renal cell cancer. 2) Acetaminophen and nonaspirin NSAID use increased risk. 3) Researchers observed similar risk trends for high-dose analgesics use.
1) Risk was further increased by being overweight, inactive lifestyle. 2) Dietary pattern may increase insulin resistance. 3) Altering diet could serve as colorectal cancer prevention method.
1) Drinking plenty of fluids reduced men’s risk for bladder cancer. 2) Men drank fewer liquids as they aged. 3) Physicians should feel comfortable recommending that patients drink plenty of low-sugar fluids.
1) Erythorbate added to hot dogs reduced the content of possibly carcinogenic N-nitroso compounds. 2) Time trends in the incidence of colon cancer may not support the view that N-nitroso compounds in processed meat are a cause of colon cancer.
1) Autosomal dominant polycystic kidney disease affects 12.5 million people worldwide; some patients develop severe disease during early childhood 2) Certain genetic mutations aggravate the disease and cause early symptoms 3) Genetic tests could identify who’s at risk for early disease.
1) Patient characteristics affect whether dialysis clinics achieve treatment success and receive Medicare reimbursement. 2) How well kidney disease patients follow their prescribed treatments has the greatest impact. 3) Dialysis clinics in low-income urban areas provide care to more patients who don’t follow their prescribed treatments; these clinics get unfairly penalized.
1) Patients who take at least one blood pressure-lowering medication at bedtime have better control of their blood pressure and are less likely to experience heart problems than patients who take medications in the morning. 2) Sleep-time blood pressure is a better measure of heart health than wake-time blood pressure. 3) About one out of three U.S. adults has high blood pressure.
Low vitamin D levels are associated with an increased risk of developing multiple sclerosis (MS), but the first randomized, controlled trial using high-dose vitamin D in MS did not find any added benefit over and above ongoing low-dose vitamin D supplementation, according to a study published in the October 25, 2011, issue of Neurology®, the medical journal of the American Academy of Neurology.
Oncolytic viral therapy shows great potential for treating an aggressive form of breast cancer
Yoga classes were found to be more effective than a self-care book for patients with chronic low back pain at reducing symptoms and improving function, but they were not more effective than stretching classes, according to a study published Online First by the Archives of Internal Medicine.
An analysis of financial payments made by orthopedic device manufacturers to orthopedic surgeons shows that the patterns of payments from 2007 to 2010 appear to be complex with a reduction in the total number of payments and the total amount of funds distributed after payment disclosure was required, as well as an increase in the proportion of consultants with academic affiliations, according to a report in the October 24 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
A model used to estimate breast cancer survival rates found that the probability that a woman with screen-detected breast cancer will avoid a breast cancer death because of screening mammography may be lower than previously thought, according to a report published Online First by Archives of Internal Medicine, one of the JAMA/Archives journals.
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