Using a next generation sequencing analysis to examine human endogenous retrovirus (HERV) integration sites, researchers from Kumamoto University, the National Institute of Genetics (Japan), and the University of Michigan (USA) have discovered that these ancient retroviruses can undergo retrotransposition (DNA sequence insertion with RNA mediation) into iPS cells.
Poor healing of cutaneous wounds is a common medical problem in the field of traumatology. Due to the intricate pathophysiological processes of wound healing, the use of conventional treatment methods, such as chemical molecule drugs and tradit
Pharmacological inhibitors of glutathione synthesis and circulation, such as buthionine-sulfoximine, inhibit glutathione metabolism. These drugs decrease the aggressiveness of pancreatic cancer, inhibit tumor stem cell survival, and reduce chem
BACKGROUNDDiabetes mellitus (DM) is a serious and growing global health burden. It is estimated that 80% of diabetic patients have micturition problems such as poor emptying, urinary incontinence, urgency, and urgency incontinence. Patients wit
BACKGROUNDHuman Wharton’s jelly-derived mesenchymal stromal/stem cells (hWJ-MSCs) have gained considerable attention in their applications in cell-based therapy due to several advantages offered by them. Recently, we reported that hWJ-MSCs an
UC Davis Comprehensive Cancer Center has a new chief science officer and associate director for basic science. Xiao-Jing Wang comes from the University of Colorado Anshutz Medical Campus where she focused on skin as well as head and neck cancers
A stomach adult stem cell population can fulfill two distinct functions: either help with digestion under normal conditions or take the lead on injury response.
Announcement of Koen van Besien, MD, PhD, being named leader of the new Wesley Center for Immunotherapy at University Hospitals Seidman Cancer Center in Cleveland, Ohio. He also will head the Division of Hematology.
Yi Liu, Bowen Zheng, Yuan Zhong
TianLei Xie, Zhongqing Zhang, Wenmin Cao, Wei Chen, Hongqian Guo, Junlong Zhuang
Lijun Wang, Lihui Wang, Rongli Wang, Ting Xu, Jingyuan Wang, Zhiwei Cui, Feiyan Cheng, Wei Wang, Xinyuan Yang
Daniel Richard, Steven Pregizer, Divya Venkatasubramanian, Pushpanathan Muthuirulan, Zun Liu, Terence D. Capellini, April M. Craft
Two nationally recognized experts in cloning and stem cell science from the University of Houston are taking the first step toward limiting the consequences of chronic inflammation in cystic fibrosis (CF) by identifying the source of this persistent and enigmatic inflammation in CF lungs.
Fabiën Belle, Tomáš Sláma, Christina Schindera, Tamara Diesch, Mutlu Kartal-Kaess, Claudia Kuehni, Luzius Mader
Raquel Rua Martins, Michael Rera, Catarina M. Henriques
Tahir Haideri, Alessandro Howells, Yuqian Jiang, Jian Yang, Xiaoping Bao, Xiaojun Lian
Yaiza Nunez-Alvarez, Tristan Espie--Caullet, Reini F Luco
Belen Alvarez-Palomo, Anna Veiga, Angel Raya, Margarita Codinach, Silvia Torrents, Laura Ponce Verdugo, Clara Rodriguez-Aierbe, Leopoldo Cuellar, Raquel Alenda, Cristina Arbona, Dolores Hernández-Maraver, Cristina Fusté, Sergi Querol
Hojjatollah Nazari, Asieh Heirani, Masoud Soleimani, Reza Akbari Asbagh, Behnam Behboudi, Mohammad Sadegh Fazeli, Mojgan Rahimi, Mohammad Reza Keramati, Amir Keshvari, Alireza Kazemeini, Foroogh Alborzi, Seyed Mohsen Ahmadi Tafti
Yuki Nakafusa, Naoyoshi Nitta, Kazunari Ishii, Naoto Shirasu, Takahiro Iwamoto, Takayuki Nemoto, Masafumi Nakamura, Masafumi Goto, Hiroo Iwata, Masaru Taniguchi, Yohichi Yasunami
Ishan Goswami, Eleonora de Klerk, Phichitpol Carnese, Matthias Hebrok, Kevin Healy
Min Luo, Hui Zhang, Chaoke Bu, Zhiyong Peng, Guangchao Li, Zhao Zhou, Wen Ding, Yongwei Zheng, Yingyi He, Zhengbin Hu, Kunlin Pei, Chunfu Li
Hyo Sung Jung, Seyoung Koo, Miae Won, Seeun An, Haebeen Park, Jonathan Sessler, Jiyou Han, Jong Seung Kim
Sudip Paul, Masamitsu Sone, Ashwini Patil, Hisaya Kato, Yoshiro Maezawa, Motohiko Oshima, Masaki Fukuyo, Bahityar Rahmutulla, Yasuo Ouchi, Kyoko Tsujimura, Mahito Nakanishi, Atsushi Kaneda, Atsushi Iwama, Koutaro Yokote, Koji Eto, Naoya Takayama
Hana Najahi, Nicola Alessio, Tiziana Squillaro, Gea Oliveri Conti, Margherita Ferrante, Giovanni Di Bernardo, Umberto Galderisi, Imed Messaoudi, Sergio Minucci, Mohamed Banni
Jixian Xiong, Yuting Li, Xiangyu Tan, Tie Chen, Baohua Liu, Li Fu
Takeshi Fujimori, Yuki Shibayama, Takahiro Kanda, Kenta Suzuki, Daisuke Ogawa, Ryo Ishikawa, Kyuichi Kadota, Toru Matsunaga, Keisuke Miyake, Akira Nishiyama, Takashi Tamiya
Zhihua Chen, Yilin Lin, Suyong Lin, Xiaoyu Yang, Shao-Qin Chen
Maxime Fredon, Margaux Poussard, Sabeha Biichle, Francis Bonnefoy, Evan Seffar, Elodie Bôle-Richard, Florian Renosi, Romain Boidot, François Anna, Maria Loustau, Julien Caumartin, Philippe Saas, Eric Deconinck, Etienne Daguindeau, Xavier Roussel, Olivier Adotevi, Fanny Angelot-Delettre, Jeanne Galaine, Francne Garnache-Ottou
Roqaye Karimi, Amir Atashi, Mina Soufi Zomorrod, Monireh Agami, Mansoureh Ajami
Negin Samadi Kharajouei
UNC-Chapel Hill scientists boosted electrical activity between cells in the hypothalamus and the hippocampus to create new neurons – an important process called neurogenesis -- in animal models.
Céline Hervieu, Mireille Verdier, Gaëlle Bégaud, Niki Christou, Magali Sage, Julie Pannequin, Serge Battu, Muriel Mathonnet
Jingan Chen, Yi Liu, Jingwen Zhang, Haowei Liang, Ting Li, Li Yan, Li Zhou, Letian Shan, Hui Wang
Hitomi Nagayama, Jun Ooi
Li-E Zhu, Hui-Ping Huang, Yi-Peng Cai, Yan Wang, Bao-Hua Xu, Mao-Bai Liu, Xue-Mei Wu
Rajib Shome, Plaboni Sen, Siddhartha Sankar Ghosh
Factor Bioscience Inc., a Cambridge-based biotechnology company focused on developing mRNA and cell-engineering technologies, announced its participation in the American Society of Gene & Cell Therapy (ASGCT) 25th Annual Meeting to be held in Washington, D.C. from May 16-19, 2022.
Background Relapse is the leading cause of death from myeloid malignancies after allogeneic hematopoietic stem cell transplantation (HSCT). Azacitidine has gained attention in recent years in the prophylaxis of relapsed refractory hematologic …
Conditioning with treosulfan and fludarabine (Treo/Flu) has been proven to be feasible and efficient in several types of malignancies before allogeneic hematopoietic stem cell transplantation (allo-HSCT). Given its favorable reduced …
It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this …
… Given the important function of PTBP1 in directing lineage choice in diverse stem cell systems and the overall relevance of mRNA splicing in hematopoiesis, we hypothesized that PTBP1 might play a role as a regulator of posttranscriptional …
… To investigate the status of the T-cell compartment of UPN1 up to 51 years post-HSCT in the context of a stem cell boost at 37 years after HSCT, we aimed to combine detailed phenotyping with TCR repertoire analysis. Development of a T-cell-focused …
Jing Yuan, Zhen-Zhen Wang, Han-Yun Ren, Fu-Xu Wang
The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs development pipeline by mimicking the physiological environment and functions of human organs. The translational value of OoC is further enhanced when …
… for Atg5, the stem cell loss in vivo was more pronounced than in vitro, suggesting that additional cell populations likely depend upon Atg5 function to support ileum health. We first tested whether ATG5-dependent WNT signaling was required for …
… With Select-seq, we analyse the cancer stem cell-like microniches in relation to the tumour microenvironment of triple-negative breast cancer patients. We identify alternative splice variants, perform complementarity-determining region analysis of …
Over the last 30 years, allogeneic haematopoietic stem cell transplantation (allo‐HSCT) has been adopted as a therapeutic strategy for many inborn errors of metabolism (IEM), due to the ability of donor‐derived cells to provide life‐long enzyme delivery to …
Youxiang Su, Nianhu Li, Jian Xin, Shang Gao, Yun Song, Xintian Qu, Yan Liu, Xiusen Ma
Renal fibrosis is a common pathological process of chronic kidney diseases induced by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance the efficacy of secreted extracellular vesicles (MSC-EVs) on various diseases, but it …
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