Feature Channels: Stem Cells

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Released: 29-Sep-2023 8:05 AM EDT
A lethal parasite’s secret weapon: infecting non-immune cells
Ohio State University

The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.

Released: 28-Sep-2023 4:05 PM EDT
UC Irvine named one of CIRM’s cell and gene therapy manufacturing facilities
University of California, Irvine

Irvine, Calif., Sept. 28, 2023 — With a two-year, $2 million grant from the California Institute for Regenerative Medicine, the University of California, Irvine has earned membership in CIRM’s Cell and Gene Therapy Manufacturing Network.

Newswise: Researchers discover disease-causing stem cells in lungs of cystic fibrosis patients
Released: 27-Sep-2023 5:05 PM EDT
Researchers discover disease-causing stem cells in lungs of cystic fibrosis patients
University of Houston

Two nationally recognized experts in cloning and stem cell science from the University of Houston, Wa Xian and Frank McKeon, are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis (CF), and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.

Released: 26-Sep-2023 12:00 PM EDT
Mechanism of adipose-derived mesenchymal stem cell exosomes in the treatment of heart failure
World Journal of Stem Cells

BACKGROUNDHeart failure (HF) is a global health problem characterized by impaired heart function. Cardiac remodeling and cell death contribute to the development of HF. Although treatments such as digoxin and angiotensin receptor blocker dr

Released: 26-Sep-2023 12:00 PM EDT
Multiomics reveal human umbilical cord mesenchymal stem cells improving acute lung injury via the lung-gut axis
World Journal of Stem Cells

BACKGROUNDAcute lung injury (ALI) and its final severe stage, acute respiratory distress syndrome, are associated with high morbidity and mortality rates in patients due to the lack of effective specific treatments. Gut microbiota homeostas

Released: 26-Sep-2023 12:00 PM EDT
Integrin beta 3-overexpressing mesenchymal stromal cells display enhanced homing and can reduce atherosclerotic plaque
World Journal of Stem Cells

BACKGROUNDUmbilical cord (UC) mesenchymal stem cell (MSC) transplantation is a potential therapeutic intervention for atherosclerotic vascular disease. Integrin beta 3 (ITGB3) promotes cell migration in several cell types. However, whether

Released: 26-Sep-2023 12:00 PM EDT
Enhanced wound healing and hemostasis with exosome-loaded gelatin sponges from human umbilical cord mesenchymal stem cells
World Journal of Stem Cells

BACKGROUNDRapid wound healing remains a pressing clinical challenge, necessitating studies to hasten this process. A promising approach involves the utilization of human umbilical cord mesenchymal stem cells (hUC-MSCs) derived exosomes. The

Newswise: Regenerative Medicine: How Scientists Manufacture Cells
Released: 19-Sep-2023 11:05 AM EDT
Regenerative Medicine: How Scientists Manufacture Cells
Cedars-Sinai

In 1998, scientists reported being able to derive cells from human embryos that could develop into almost any cell in the body. In 2007, the field took a huge leap when scientists discovered they could reprogram human adult skin cells to act like these embryonic stem cells.

Released: 11-Sep-2023 3:05 PM EDT
Stem cell-derived components may treat underlying causes of PCOS
University of Chicago Medical Center

UChicago researchers recently unveiled a potential new PCOS treatment that restored ovarian function and improved hormonal and metabolic regulation in mice.

29-Aug-2023 5:55 PM EDT
New study shows promising evidence for sickle cell gene therapy
University of Chicago Medical Center

UChicago Medicine Comer Children’s Hospital was one of three sites to enroll patients in a clinical trial to test a potentially curative stem cell gene therapy for sickle cell disease. The results were promising.

Released: 29-Aug-2023 3:15 PM EDT
UC Davis Eye Center tests experimental gene therapy for wet age-related macular degeneration (AMD)
UC Davis Health

Ophthalmologists at UC Davis Health used an experimental gene therapy last month to treat a patient with wet age-related macular degeneration, or wet AMD. Wet AMD is a leading cause of vision loss among older adults. Glenn Yiu, a professor of ophthalmology at UC Davis Health, is the principal investigator for the new clinical trial.

Released: 26-Aug-2023 12:00 PM EDT
Up-to-date meta-analysis of long-term evaluations of mesenchymal stem cell therapy for complex perianal fistula
World Journal of Stem Cells

BACKGROUNDLocal mesenchymal stem cell (MSC) therapy for complex perianal fistulas (PFs) has shown considerable promise. But, the long-term safety and efficacy of MSC therapy in complex PFs remain unknown. AIMTo explore the long-term effect

Released: 26-Aug-2023 12:00 PM EDT
Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis
World Journal of Stem Cells

BACKGROUNDIntervertebral disc degeneration (IDD) is a main contributor to low back pain. Oxidative stress, which is highly associated with the progression of IDD, increases senescence of nucleus pulposus-derived mesenchymal stem cells (NPMS

Released: 26-Aug-2023 12:00 PM EDT
Wnt signaling pathway inhibitor promotes mesenchymal stem cells differentiation into cardiac progenitor cells in vitro and improves cardiomyopathy in vivo
World Journal of Stem Cells

BACKGROUNDCardiovascular diseases particularly myocardial infarction (MI) are the leading cause of mortality and morbidity around the globe. As cardiac tissue possesses very limited regeneration potential, therefore use of a potent small mo

Released: 26-Aug-2023 12:00 PM EDT
Constitutive aryl hydrocarbon receptor facilitates the regenerative potential of mouse bone marrow mesenchymal stromal cells
World Journal of Stem Cells

BACKGROUNDBone marrow mesenchymal stromal cells (BMSCs) are the commonly used seed cells in tissue engineering. Aryl hydrocarbon receptor (AhR) is a transcription factor involved in various cellular processes. However, the function of const

Released: 26-Aug-2023 12:00 PM EDT
Interferon-gamma and tumor necrosis factor-alpha synergistically enhance the immunosuppressive capacity of human umbilical-cord-derived mesenchymal stem cells by increasing PD-L1 expression
World Journal of Stem Cells

BACKGROUNDThe immunosuppressive capacity of mesenchymal stem cells (MSCs) is dependent on the “license” of several proinflammatory factors to express immunosuppressive factors such as programmed cell death 1 ligand 1 (PD-L1), which dete

Released: 26-Aug-2023 12:00 PM EDT
Mastering the craft: Creating an insightful and widely-cited literature review
World Journal of Stem Cells

The art of constructing an insightful literature review manuscript has witnessed an exemplar in the work of Oz et al (2023), wherein concept progression harmoniously merges with figures and tables. Reflecting on retrospective data science,

Newswise: Myocardial infarction, the number one cause of sudden death, may be treated by modulating the immune response
Released: 25-Aug-2023 12:00 AM EDT
Myocardial infarction, the number one cause of sudden death, may be treated by modulating the immune response
National Research Council of Science and Technology

Dr. Yoon Ki Joung and Dr. Juro Lee of the Biomaterials Research Center at the Korea Institute of Science and Technology (KIST), together with Prof. Hun-Jun Park and Dr. Bong-Woo Park of the Catholic University of Korea College of Medicine, have developed a new treatment for myocardial infarction that uses nanovesicles derived from fibroblasts with induced apoptosis to modulate the immune response.

Newswise: Mutations in blood stem cells can exacerbate colon cancer
21-Aug-2023 9:45 AM EDT
Mutations in blood stem cells can exacerbate colon cancer
The Rockefeller University Press

Researchers at the University of Florida College of Medicine have discovered how common age-related changes in the blood system can make certain colon cancers grow faster.

Newswise: Cell Therapy That Repairs Cornea Damage with Patient’s Own Stem Cells Achieves Positive Phase I Trial Results
Released: 18-Aug-2023 2:10 PM EDT
Cell Therapy That Repairs Cornea Damage with Patient’s Own Stem Cells Achieves Positive Phase I Trial Results
Massachusetts Eye and Ear

Cultivated autologous limbal epithelial cells (CALEC) transplant, in which stem cells from the healthy eye and transplanted into the injured eye, for significant cornea injuries was found safe and led to gains in preliminary phase I clinical trial.

Released: 14-Aug-2023 5:00 AM EDT
A Neurogenic Signature Involving Monoamine Oxidase-A controls Human Thermogenic Adipose Tissue Development
bioRxiv

Mechanisms that control “beige/brite” thermogenic adipose tissue development may be harnessed to improve human metabolic health. To define these mechanisms, we developed a species-hybrid model in which human mesenchymal progenitor cells were used to develop white or thermogenic/beige adipose tissue in mice.

Released: 10-Aug-2023 3:50 PM EDT
Scientists reveal two paths to autism in the developing brain
Yale University

Two distinct neurodevelopmental abnormalities that arise just weeks after the start of brain development have been associated with the emergence of autism spectrum disorder, according to a new Yale-led study in which researchers developed brain organoids from the stem cells of boys diagnosed with the disorder.

Newswise: Scientists harness the power of AI to shed light on different types of Parkinson’s disease
Released: 10-Aug-2023 3:40 PM EDT
Scientists harness the power of AI to shed light on different types of Parkinson’s disease
Francis Crick Institute

Researchers at the Francis Crick Institute and UCL Queen Square Institute of Neurology, working with technology company Faculty AI, have shown that machine learning can accurately predict subtypes of Parkinson’s disease using images of patient-derived stem cells.

   
Newswise: Stem Cell Therapy Rescues Symptoms of Alzheimer’s Disease
Released: 9-Aug-2023 4:05 PM EDT
Stem Cell Therapy Rescues Symptoms of Alzheimer’s Disease
University of California San Diego

Promising preclinical results from UC San Diego show hematopoietic stem cell therapy was effective in rescuing memory loss, neuroinflammation and beta amyloid build-up in a mouse model of Alzheimer’s disease.

Newswise: New Chief of Pediatric Bone Marrow Transplantation and Cellular Therapies Named to New Jersey’s Only NCI-designated Comprehensive Cancer Center
Released: 9-Aug-2023 10:15 AM EDT
New Chief of Pediatric Bone Marrow Transplantation and Cellular Therapies Named to New Jersey’s Only NCI-designated Comprehensive Cancer Center
Rutgers Cancer Institute of New Jersey

Rutgers Cancer Institute of New Jersey and RWJBarnabas Health have appointed Niketa C. Shah, MD, as chief of Pediatric Bone Marrow Transplantation and Cellular Therapies at New Jersey’s leading cancer program.

Newswise: Organoids revolutionize research on respiratory infections
Released: 1-Aug-2023 3:05 PM EDT
Organoids revolutionize research on respiratory infections
École Polytechnique Fédérale de Lausanne (EPFL)

Biofilms are highly resistant communities of bacteria that pose a major challenge in the treatment of infections.

Newswise: New Insights into Heterotopic Ossification: Progenitor Cells Play a Key Role in Aberrant Bone Formation
Released: 1-Aug-2023 12:40 PM EDT
New Insights into Heterotopic Ossification: Progenitor Cells Play a Key Role in Aberrant Bone Formation
Chinese Academy of Sciences

Heterotopic ossification (HO), a pathological condition characterized by abnormal bone formation in soft tissues, can result from traumatic injuries like fractures and surgeries such as hip arthroplasty. The underlying cellular mechanisms and specific cell phenotypes driving this process remain poorly understood due to the complex heterogeneity of the involved progenitor cells.

Released: 28-Jul-2023 11:30 AM EDT
Neonatal Stem Cells from the Heart Could Treat Crohn’s Disease
Ann and Robert H. Lurie Children's Hospital of Chicago

Research from Ann & Robert H. Lurie Children’s Hospital of Chicago found that direct injection of neonatal mesenchymal stem cells, derived from heart tissue discarded during surgery, reduces intestinal inflammation and promotes wound healing in a mouse model of Crohn’s disease-like ileitis, an illness marked by chronic intestinal inflammation and progressive tissue damage.

Newswise: LJI and Kyowa Kirin launch immunology fellowship program
Released: 27-Jul-2023 2:55 PM EDT
LJI and Kyowa Kirin launch immunology fellowship program
La Jolla Institute for Immunology

Support for early career researchers is about to get a major boost, thanks to a new fellowship fund established by leaders at La Jolla Institute for Immunology (LJI) and Japan-based global pharmaceutical corporation, Kyowa Kirin, Inc.

   
Newswise:Video Embedded stem-cell-transplant-helps-treat-scleroderma
VIDEO
Released: 27-Jul-2023 2:40 PM EDT
Stem Cell Transplant Helps Treat Scleroderma
Michigan Medicine - University of Michigan

After the successful treatment, a patient shares his story to inspire others.

24-Jul-2023 11:10 AM EDT
CHOP and Penn Medicine Researchers Develop “In Vivo” RNA-based Gene Editing Model for Blood Disorders
Children's Hospital of Philadelphia

In a step forward in the development of genetic medicines, researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body. If translated into the clinic, this approach could expand access and reduce the cost of gene therapies for blood disorders, many of which currently require patients receive chemotherapy and a stem cell transplant. The findings were published today in the journal Science.

Newswise: UC San Diego Health among First in Nation to Perform Regenerative Brain Cell Procedure for Epilepsy
Released: 26-Jul-2023 4:05 PM EDT
UC San Diego Health among First in Nation to Perform Regenerative Brain Cell Procedure for Epilepsy
UC San Diego Health

UC San Diego Health is among the first in the nation to perform an experimental regenerative brain cell therapy for epilepsy aimed at eliminating seizures.

Released: 26-Jul-2023 12:00 PM EDT
Injectable hydrogel made from antler mesenchyme matrix for regenerative wound healing via creating a fetal-like niche
World Journal of Stem Cells

BACKGROUNDScar formation and loss of cutaneous appendages are the greatest challenges in cutaneous wound healing. Previous studies have indicated that antler reserve mesenchyme (RM) cells and their conditioned medium improved regenerative w

Released: 26-Jul-2023 12:00 PM EDT
Zinc enhances the cell adhesion, migration, and self-renewal potential of human umbilical cord derived mesenchymal stem cells
World Journal of Stem Cells

BACKGROUNDZinc (Zn) is the second most abundant trace element after Fe, present in the human body. It is frequently reported in association with cell growth and proliferation, and its deficiency is considered to be a major disease contribut

Released: 26-Jul-2023 12:00 PM EDT
Generation of a human haploid neural stem cell line for genome-wide genetic screening
World Journal of Stem Cells

BACKGROUNDHaploid embryonic stem cells (haESCs) have been established in many species. Differentiated haploid cell line types in mammals are lacking due to spontaneous diploidization during differentiation that compromises lineage-specific

Released: 26-Jul-2023 12:00 PM EDT
Transplantation of human induced pluripotent stem cell derived keratinocytes accelerates deep second-degree burn wound healing
World Journal of Stem Cells

BACKGROUNDCurrent evidence shows that human induced pluripotent stem cells (hiPSCs) can effectively differentiate into keratinocytes (KCs), but its effect on skin burn healing has not been reported. AIMTo observe the effects of hiPSCs-deri

Released: 26-Jul-2023 12:00 PM EDT
Commitment of human mesenchymal stromal cells to skeletal lineages is independent of their morphogenetic capacity
World Journal of Stem Cells

BACKGROUNDMesenchymal stromal cells (MSCs) are multipotent cell populations obtained from fetal and adult tissues. They share some characteristics with limb bud mesodermal cells such as differentiation potential into osteogenic, chondrogeni

Released: 26-Jul-2023 12:00 PM EDT
Neural stem cells for Parkinson’s disease management: Challenges, nanobased support, and prospects
World Journal of Stem Cells

Parkinson’s disease (PD), characterized by loss of nigrostriatal dopaminergic neurons, is one of the most predominant neurodegenerative diseases affecting the elderly population worldwide. The concept of stem cell therapy in managing neur

Released: 26-Jul-2023 12:00 PM EDT
Human retinal secretome: A cross-link between mesenchymal and retinal cells
World Journal of Stem Cells

In recent years, mesenchymal stem cells (MSC) have been considered the most effective source for regenerative medicine, especially due to released soluble paracrine bioactive components and extracellular vesicles. These factors, collectivel

Released: 26-Jul-2023 12:00 PM EDT
Could extracellular vesicles derived from mesenchymal stem cells be a potential therapy for acute pancreatitis-induced cardiac injury?
World Journal of Stem Cells

Acute pancreatitis (AP) often leads to a high incidence of cardiac injury, posing significant challenges in the treatment of severe AP and contributing to increased mortality rates. Mesenchymal stem cells (MSCs) release bioactive molecules

Released: 24-Jul-2023 4:05 PM EDT
Researchers Identify the Cellular Mechanisms by Which Lactate Helps our Brains Develop
Tohoku University

Scientists at Tohoku University have discovered the critical role that lactate plays in helping neural stem cells develop into specialized neurons, a process dubbed neuronal differentiation.

Released: 21-Jul-2023 11:55 AM EDT
Oldest known molecule surprises researchers. It could lead to new important treatments
University of Copenhagen, Faculty of Health and Medical Sciences

The human body consists of numerous trillions of cells, and 60 percent of the energy used within a cell is dedicated to a specific molecular machine. That machine is responsible for producing proteins, which are fundamental building blocks of the body.

   
Newswise: UT Southwestern stem cell biologists develop embryo model
Released: 20-Jul-2023 2:30 PM EDT
UT Southwestern stem cell biologists develop embryo model
UT Southwestern Medical Center

UT Southwestern Medical Center biologists have developed a new stem cell-based embryo model for studying early human development, tissue formation, and differentiation, offering valuable contributions to the field of developmental biology and regenerative medicine.

Newswise: Powerhouse proteins protect heart cells from chemotherapy damage 
Released: 20-Jul-2023 2:05 PM EDT
Powerhouse proteins protect heart cells from chemotherapy damage 
University of Illinois Chicago

Researchers at the University of Illinois Chicago have identified a process by which enzymes can help prevent heart damage in chemotherapy patients

   
Released: 18-Jul-2023 12:00 PM EDT
Life on Earth didn’t arise as described in textbooks
University of Copenhagen, Faculty of Science

No, oxygen didn’t catalyze the swift blossoming of Earth’s first multicellular organisms. The result defies a 70-year-old assumption about what caused an explosion of oceanic fauna hundreds of millions of years ago.

Newswise: gladstone_devcell-vasic-hero.jpg?itok=Pp3YvR2y
Released: 18-Jul-2023 11:45 AM EDT
A key function for tight junctions in embryo models
Gladstone Institutes

As a human embryo grows, a set of molecules directs cells as they multiply and take on specific identities and spatial positions within the embryo. In one crucial step known as gastrulation, these signaling molecules guide a single layer of embryonic stem cells to form three layers of distinct cell types that will later become different parts of the body.

   
Released: 13-Jul-2023 7:00 AM EDT
Artificially grown ‘mini-brains’ without animal components bring opportunities for neuroscience
Michigan Medicine - University of Michigan

Researchers at University of Michigan developed a method to produce artificially grown miniature brains — called human brain organoids — free of animal cells that could greatly improve the way neurodegenerative conditions are studied and, eventually, treated. The work offers a solution to overcome Matrigel’s weaknesses.

Released: 10-Jul-2023 4:05 PM EDT
Hematopoietic stem cell culture technology for more effective and safer genome editing
University of Tsukuba

Hematopoietic stem cells (HSCs) are rare cells found in the bone marrow that produce red blood cells, white blood cells, and platelets.

Newswise: New Insight into How Plant Cells Divide
6-Jul-2023 1:00 PM EDT
New Insight into How Plant Cells Divide
University of California San Diego

Plant and animal stem cells both rely on the cytoskeleton to divide properly, but a new study finds that they use them in opposite ways—while animal cells pull on the cytoskeleton, plant cells push it away. Harnessing that action could help scientists engineer more resilient plants.



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