Feature Channels: Stem Cells

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Released: 28-May-2020 12:55 PM EDT
Stem Cell Treatments ‘Go Deep’ to Regenerate Sun-Damaged Skin
Wolters Kluwer Health: Lippincott Williams and Wilkins

For a while now, some plastic surgeons have been using stem cells to treat aging, sun-damaged skin. But while they’ve been getting good results, it’s been unclear exactly how these treatments – using adult stem cells harvested from the patient’s own body – work to rejuvenate “photoaged” facial skin.

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Embargo will expire: 2-Jun-2020 11:00 AM EDT Released to reporters: 28-May-2020 11:00 AM EDT

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access_time Embargo lifts in 2 days
Embargo will expire: 2-Jun-2020 11:00 AM EDT Released to reporters: 28-May-2020 4:45 AM EDT

A reporter's PressPass is required to access this story until the embargo expires on 2-Jun-2020 11:00 AM EDT The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.

Newswise: Treatment shows promise in treating deadly brain cancer
25-May-2020 8:55 AM EDT
Treatment shows promise in treating deadly brain cancer
McMaster University

In this study, researchers investigated if specific targeting of CD133+ glioblastoma with cutting-edge immunotherapy drugs could eradicate the most aggressive subpopulation of cells in the tumour. They also looked at the safety of CD133-targeting therapies on normal, non-cancerous human stem cells including hematopoietic stem cells which create blood cells and progenitor cells which can form one or more kinds of cells.

Newswise: Rejuvenated fibroblasts can recover the ability to contract
Released: 26-May-2020 9:00 AM EDT
Rejuvenated fibroblasts can recover the ability to contract
National University of Singapore

A recent study from the Mechanobiology Institute at the National University of Singapore has shown that rejuvenated fibroblasts can recover their ability to self-contract. This encouraging discovery holds great potential for applications in regenerative medicine and stem cell engineering.

Newswise: Image Analysis Technique Provides Better Understanding of Heart Cell Defects
11-May-2020 8:05 AM EDT
Image Analysis Technique Provides Better Understanding of Heart Cell Defects
American Institute of Physics (AIP)

Many patients with heart disease face limited treatment options. Fortunately, stem cell biology has enabled researchers to produce large numbers of cardiomyocytes, which may be used in advanced drug screens and cell-based therapies. However, current image analysis techniques don’t allow researchers to analyze heterogeneous, multidirectional, striated myofibrils typical of immature cells. In the Journal of Applied Physics, researchers showcase an algorithm that combines gradient methods with fast Fourier transforms to quantify myofibril structures in heart cells with considerable accuracy.

Newswise: Hackensack Meridian Health Invests in EpiBone, Inc., 
A Regenerative Medicine Company
Released: 19-May-2020 10:50 AM EDT
Hackensack Meridian Health Invests in EpiBone, Inc., A Regenerative Medicine Company
Hackensack Meridian Health

EpiBone’s Craniomaxillofacial, or EB-CMF, product is a living, anatomically correct bone graft made from a patient’s own fat-derived stem cells.

Released: 14-May-2020 2:10 PM EDT
Surplus antioxidants are pathogenic for hearts and skeletal muscle
University of Alabama at Birmingham

Oxidative stress can be pathological. Now researchers report that the other end of the redox spectrum, reductive stress, is also pathological. Reductive stress causes pathological heart enlargement and diastolic dysfunction in a mouse model.

Newswise: Scientists show MRI predicts the efficacy of a stem cell therapy for brain injury
11-May-2020 12:45 PM EDT
Scientists show MRI predicts the efficacy of a stem cell therapy for brain injury
Sanford Burnham Prebys Medical Discovery Institute

Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve efficacy. The study was published in Cell Reports.

Newswise: UCLA scientists create first roadmap of human skeletal muscle development
Released: 11-May-2020 12:15 PM EDT
UCLA scientists create first roadmap of human skeletal muscle development
University of California, Los Angeles (UCLA), Health Sciences

An interdisciplinary team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA has developed a first-of-its-kind roadmap of how human skeletal muscle develops, including the formation of muscle stem cells.

Released: 7-May-2020 4:50 PM EDT
Bioethicist calls out unproven and unlicensed 'stem cell treatments' for COVID-19
Cell Press

As the COVID-19 pandemic enters its third month, businesses in the United States are marketing unlicensed and unproven stem-cell-based "therapies" and exosome products that claim to prevent or treat the disease. In Cell Stem Cell on May 5, bioethicist Leigh Turner describes how these companies are "seizing the pandemic as an opportunity to profit from hope and desperation."

Released: 7-May-2020 2:35 PM EDT
Stem cells shown to delay their own death to aid healing
Cornell University

A new study shows how stem cells – which can contribute to creating many parts of the body, not just one organ or body part – are able to postpone their own death in order to respond to an injury that needs their attention. The study was done in planarians, which are tiny worms used as model organisms to study regeneration because of their ability to recover from any injury using stem cells.

29-Apr-2020 6:25 PM EDT
New targets for childhood brain tumors identified
Washington University in St. Louis

People with the genetic condition neurofibromatosis type 1 (NF1) are prone to developing tumors on nervous system tissue. A new study from Washington University School of Medicine in St. Louis has found that the development and growth of such tumors are driven by nearby noncancerous neurons and immune cells. The findings point to potential new therapeutic targets for people with NF1.

Newswise: Four UTSW faculty elected to prestigious National Academy of Sciences
Released: 29-Apr-2020 12:45 PM EDT
Four UTSW faculty elected to prestigious National Academy of Sciences
UT Southwestern Medical Center

The National Academy of Sciences today elected four UT Southwestern Medical Center scientists in the fields of biophysics, cell biology, molecular biology, and stem cell biology into its membership, one of the highest honors for American scientists.

Newswise: Soup to Nuts
Released: 27-Apr-2020 11:35 AM EDT
Soup to Nuts
Harvard Medical School

The COVID-19 pandemic demands action on many fronts, from prevention to testing to treatment. Not content to focus its research efforts on just one, the laboratory of George Church in the Blavatnik Institute at Harvard Medical School and the Wyss Institute for Biologically Inspired Engineering at Harvard University is tackling the problem from seven different angles.

Newswise: UCLA scientists receive grants for COVID-19 research from California’s stem cell agency
Released: 24-Apr-2020 4:55 PM EDT
UCLA scientists receive grants for COVID-19 research from California’s stem cell agency
University of California, Los Angeles (UCLA), Health Sciences

Three researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received awards to pursue treatments and vaccines for COVID-19 from the California Institute for Regenerative Medicine, the state’s stem cell agency.

Released: 24-Apr-2020 8:10 AM EDT
بحث مايو كلينك (Mayo Clinic) يكتشف كيف ترمم الخلايا الجذعية أضرار النوبات القلبية
Mayo Clinic

اكتشف باحثو مايو كلينك (Mayo Clinic) آليات شفاء بتنشيط الخلايا الجذعية بعد نوبة قلبية حيث أعادت الخلايا الجذعية عضلة القلب إلى حالتها قبل النوبة القلبية، ما قدم مخططًا لكيفية عمل الخلايا الجذعية.

Released: 23-Apr-2020 4:45 PM EDT
Pesquisa da Mayo Clinic descobre como as células-tronco reparam danos causados por ataques cardíacos
Mayo Clinic

Pesquisadores da Mayo Clinic descobriram mecanismos de cura ativados por células-tronco após um ataque cardíaco. As células-tronco restauraram o músculo cardíaco devolvendo-o ao seu estado anterior ao ataque cardíaco, fornecendo um esquema sobre como as células-tronco podem funcionar.

Newswise: Diabetes reversed in mice with genetically edited stem cells derived from patients
21-Apr-2020 8:50 AM EDT
Diabetes reversed in mice with genetically edited stem cells derived from patients
Washington University in St. Louis

Researchers at Washington University School of Medicine in St. Louis have used induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes, transformed the stem cells into insulin-producing cells, used the CRISPR gene-editing tool to correct a defect that caused a form of diabetes, and implanted the cells into mice to reverse diabetes in the animals.

Newswise: New Cell Therapy Trial Launches for Patients with Severe COVID-19
Released: 20-Apr-2020 4:05 PM EDT
New Cell Therapy Trial Launches for Patients with Severe COVID-19
University of Miami Health System, Miller School of Medicine

An international team of scientists led by Camillo Ricordi, M.D., director of the Diabetes Research Institute and Cell Transplant Center at the University of Miami Miller School of Medicine, has been granted immediate FDA authorization for a 24-patient clinical trial to test the safety and exploratory efficacy of umbilical cord-derived mesenchymal stem cells to block the life-threatening lung inflammation that accompanies severe cases of COVID-19.

Newswise: Signal Switch Gives MDS Cells a Competitive Advantage that Supports Disease Progression
Released: 20-Apr-2020 2:30 PM EDT
Signal Switch Gives MDS Cells a Competitive Advantage that Supports Disease Progression
Cincinnati Children's Hospital Medical Center

A study published online April 20, 2020, in Nature Immunology, led by researchers at Cincinnati Children's reports a possible new approach for treating myelodysplastic syndrome (MDS), which often can lead to leukemia.

Newswise: First COVID-19 patient in Texas enrolled in UTHealth stem cell therapy study at Memorial Hermann
Released: 17-Apr-2020 5:10 PM EDT
First COVID-19 patient in Texas enrolled in UTHealth stem cell therapy study at Memorial Hermann
University of Texas Health Science Center at Houston

The first COVID-19 patient in Texas has been enrolled in a stem cell therapy clinical trial for acute respiratory distress syndrome (ARDS) at The University of Texas Health Science Center at Houston (UTHealth).

Newswise: Cedars-Sinai Looks to Space for Tomorrow's Stem Cell Therapies
Released: 17-Apr-2020 9:00 AM EDT
Cedars-Sinai Looks to Space for Tomorrow's Stem Cell Therapies
Cedars-Sinai

Is the future of personalized medicine out of this world? Cedars-Sinai is trying to find out by launching special stem cells into space to see if they multiply better there. The Cedars-Sinai Board of Governors Regenerative Medicine Institute is partnering with Space Tango of Lexington, Kentucky, to send induced pluripotent stem cells (iPSCs) to the International Space Station. The first flight for the project, funded by a $1.5 million award from NASA, could occur as early as next year.

Newswise: When Damaged, the Adult Brain Repairs Itself by Going Back to the Beginning
Released: 15-Apr-2020 2:05 PM EDT
When Damaged, the Adult Brain Repairs Itself by Going Back to the Beginning
University of California San Diego Health

When adult brain cells are injured, they revert to an embryonic state, say researchers at UC San Diego School of Medicine. In their newly adopted immature state, the cells become capable of re-growing new connections that, under the right conditions, can help to restore lost function.

Newswise: Researchers restore sight in mice by turning skin cells into light-sensing eye cells
14-Apr-2020 6:25 PM EDT
Researchers restore sight in mice by turning skin cells into light-sensing eye cells
NIH, National Eye Institute (NEI)

Researchers have discovered a technique for directly reprogramming skin cells into light-sensing rod photoreceptors used for vision, sidestepping the need for stem cells. The lab-made rods enabled blind mice to detect light after the cells were transplanted into the animals’ eyes.

Newswise: UCI clinical trial targeting retinitis pigmentosa receives $6.6M grant from California Institute for Regenerative Medicine
Released: 13-Apr-2020 3:55 PM EDT
UCI clinical trial targeting retinitis pigmentosa receives $6.6M grant from California Institute for Regenerative Medicine
University of California, Irvine

Henry J. Klassen, MD, PhD, professor and director of the Stem Cell and Retinal Generation Program at the UCI School of Medicine, Gavin Herbert Eye Institute, and founder of jCyte, Inc., was awarded a $6.6 million dollar grant from the California Institute for Regenerative Medicine (CIRM) for a clinical trial targeting retinitis pigmentosa (RP).

Released: 10-Apr-2020 10:55 AM EDT
Hackensack Meridian Health Studying the Blood of COVID-19 Survivors
Hackensack Meridian Health

Convalescent plasma treatments could be a potential treatment method for COVID-19 cases

Released: 9-Apr-2020 1:15 PM EDT
Mount Sinai Leading the Way in Innovative Stem Cell Therapy for COVID-19 Patients
Mount Sinai Health System

Mount Sinai Health System is the first in the country to use an innovative allogeneic stem cell therapy in COVID-19 patients and will play a central role in developing and conducting a rigorous clinical trial for patients with severe acute respiratory distress syndrome, the breathing illness that afflicts people who have severe cases of COVID-19.

Newswise: UC San Diego to Advance Stem Cell Therapies in New Space Station Lab
Released: 8-Apr-2020 3:45 PM EDT
UC San Diego to Advance Stem Cell Therapies in New Space Station Lab
University of California San Diego Health

UC San Diego and Space Tango received a NASA award to develop the first dedicated stem cell research laboratory within the International Space Station.

3-Apr-2020 4:30 PM EDT
Coriell Institute Awarded $9.2M Biobanking Grant from National Institute of General Medical Sciences
Coriell Institute for Medical Research

The Coriell Institute for Medical Research has been awarded a $9.2 million grant through an open competition from the National Institute of General Medical Sciences (NIGMS). This five-year award keeps Coriell in place as the steward of the NIGMS Human Genetic Cell Repository, a world-renowned collection of high quality cell lines and DNA samples representing genetic diseases, distinct human populations around the world, and more.

Released: 6-Apr-2020 8:30 AM EDT
Estudio de Mayo Clinic descubre cómo las células madre reparan los daños por un ataque cardíaco
Mayo Clinic

Los investigadores de Mayo Clinic descubrieron cuáles son los mecanismos de recuperación que las células madre activan después de un ataque cardíaco. Las células madre restablecieron el músculo cardíaco al estado que tenía antes del ataque al corazón, lo cual, a su vez, facilitó un diagrama del posible funcionamiento de estas células.

Newswise: A direct protein-to-protein binding couples cell survival to cell proliferation
Released: 3-Apr-2020 3:20 PM EDT
A direct protein-to-protein binding couples cell survival to cell proliferation
University of Alabama at Birmingham

The regulators of apoptosis watch over cell replication and the decision to enter the cell cycle. Researchers now show a direct link between the protein MCL1 — a member of the BCL2 protein family known as the gatekeepers of apoptosis — and the cell-cycle checkpoint protein P18.

30-Mar-2020 2:00 PM EDT
Researchers Find That Nicotinamide May Help Treat Fibrotic Eye Diseases and Mitigate Vision Loss
Mount Sinai Health System

Nicotinamide can inhibit aggressive cell transformations during wound healing and may be key to the development of therapies to treat fibrotic eye diseases

Newswise: Immunotherapy using ‘young cells’ offers promising option against cancer
Released: 20-Mar-2020 6:05 PM EDT
Immunotherapy using ‘young cells’ offers promising option against cancer
Washington University in St. Louis

A new study from Washington University School of Medicine in St. Louis suggests that the age of certain immune cells used in immunotherapy plays a role in how effective it is. These cells — natural killer (NK) cells — appear to be more effective the earlier they are in development, opening the door to the possibility of an immunotherapy that would not utilize cells from the patient or a matched donor. Instead, they could be developed from existing supplies of what are called human pluripotent stem cells.

Newswise: New UCI-led study reveals how skin cells prepare to heal wounds
Released: 19-Mar-2020 2:05 PM EDT
New UCI-led study reveals how skin cells prepare to heal wounds
University of California, Irvine

A team of University of California, Irvine researchers have published the first comprehensive overview of the major changes that occur in mammalian skin cells as they prepare to heal wounds. Results from the study provide a blueprint for future investigation into pathological conditions associated with poor wound healing, such as in diabetic patients.

Released: 18-Mar-2020 2:35 PM EDT
How Gene Therapy May Hold Key to Treating Life-Threatening Cardiac Disease
University of California San Diego Health

New study finds gene therapy improved cardiac, muscle and liver function in Danon disease mouse models.

16-Mar-2020 2:10 PM EDT
Coriell Institute for Medical Research Awarded $8.6 Million Biobanking Contract from National Institute on Aging
Coriell Institute for Medical Research

The newly awarded $8.6 million funding keeps Coriell in place as the trusted steward of this collection and includes the addition of new innovative products to expand the collection. The NIA Aging Cell Repository was established at Coriell in 1974 and Coriell has continuously managed this unique resource ever since.

Newswise: Leveraging layers for enhanced tissue repair
Released: 16-Mar-2020 12:55 PM EDT
Leveraging layers for enhanced tissue repair
National Institute of Biomedical Imaging and Bioengineering

Bioengineers have created a 3D-printed scaffold designed to regenerate complex tissues composed of multiple layers of cells with different biological and mechanical properties.

Newswise: rep_francis_collins_1000px.jpg
Released: 16-Mar-2020 10:30 AM EDT
Looking to the future with Dr. Francis Collins
University of Alabama at Birmingham

At a presentation at UAB, NIH director Francis Collins outlined the top 10 area of excitement and promise in science.

Released: 12-Mar-2020 4:25 PM EDT
Mayo Clinic research discovers how stem cells repair damage from heart attacks
Mayo Clinic

Mayo Clinic researchers have uncovered stem cell-activated mechanisms of healing after a heart attack. Stem cells restored cardiac muscle back to its condition before the heart attack, in turn providing a blueprint of how stem cells may work.

Released: 10-Mar-2020 11:30 AM EDT
Muscle stem cells compiled in ‘atlas’
Cornell University

A team of Cornell researchers led by Ben Cosgrove, assistant professor in the Meinig School of Biomedical Engineering, used a new cellular profiling technology to probe and catalog the activity of almost every kind of cell involved in muscle repair. They compiled their findings into a “cell atlas” of muscle regeneration that is one of the largest datasets of its kind.

Newswise: ‘Primitive’ Stem Cells Shown to Regenerate Blood Vessels in The Eye
Released: 9-Mar-2020 9:00 AM EDT
‘Primitive’ Stem Cells Shown to Regenerate Blood Vessels in The Eye
Johns Hopkins Medicine

Johns Hopkins Medicine scientists say they have successfully turned back the biological hands of time, coaxing adult human cells in the laboratory to revert to a primitive state, and unlocking their potential to replace and repair damage to blood vessels in the retina caused by diabetes. The findings from this experimental study, they say, advance regenerative medicine techniques aimed at reversing the course of diabetic retinopathy and other blinding eye diseases.

Released: 4-Mar-2020 9:40 AM EST
‘Optical tweezers’ help in quest for better cancer treatments
Michigan State University

Stem cells involved in replenishing human tissues and blood depend on an enzyme known as telomerase to continue working throughout our lives. When telomerase malfunctions, it can lead to both cancer and premature aging conditions. Roughly 90% of cancer cells require inappropriate telomerase activity to survive.  In a groundbreaking new study, an interdisciplinary team of Michigan State University researchers has observed telomerase activity at a single-molecule level with unprecedented precision ­­­­– expanding our understanding of the vital enzyme and progressing toward better cancer treatments.

Released: 28-Feb-2020 9:35 AM EST
Inhalation Therapy Shows Promise Against Pulmonary Fibrosis in Mice, Rats
North Carolina State University

A new study shows that lung stem cell secretions – specifically exosomes and secretomes – delivered via nebulizer, can help repair lung injuries due to multiple types of pulmonary fibrosis in mice and rats.

Newswise: Researchers: Drug combination could accelerate body’s ability to heal bone fractures
Released: 27-Feb-2020 4:30 PM EST
Researchers: Drug combination could accelerate body’s ability to heal bone fractures
Beaumont Health

Scientists have discovered a combination of two commonly available drugs could boost the body’s ability to heal bone fractures – accelerating bone formation and healing.

Newswise: Newly identified cellular trash removal program helps create new neurons
Released: 27-Feb-2020 1:05 PM EST
Newly identified cellular trash removal program helps create new neurons
University of Wisconsin-Madison

New research by University of Wisconsin–Madison scientists reveals how a cellular filament helps neural stem cells clear damaged and clumped proteins, an important step in eventually producing new neurons.

Released: 27-Feb-2020 12:20 PM EST
Cells carrying Parkinson’s mutation could lead to new model for studying disease
University of Wisconsin-Madison

Parkinson’s disease researchers have used gene-editing tools to introduce the disorder’s most common genetic mutation into marmoset monkey stem cells and to successfully tamp down cellular chemistry that often goes awry in Parkinson’s patients.

Newswise: Missouri S&T researchers create organ tissue with bioactive glass, stem cells and 3D printer
Released: 27-Feb-2020 12:10 PM EST
Missouri S&T researchers create organ tissue with bioactive glass, stem cells and 3D printer
Missouri University of Science and Technology

An interdisciplinary team of Missouri S&T researchers is creating organ tissue samples using bioactive glass, stem cells and a 3D printer. The project could advance pharmaceutical testing and lead to a better understanding of how diseases affect human cells. The researchers grow stem cells and add them to hydrogels made of alginate, gelatin or similar substances.


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