Feature Channels: Stem Cells

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Released: 27-May-2022 3:05 PM EDT
Ancient Viral Elements Embedded in Human Genome Not From Fossil Retrovirus
Kumamoto University

Using a next generation sequencing analysis to examine human endogenous retrovirus (HERV) integration sites, researchers from Kumamoto University, the National Institute of Genetics (Japan), and the University of Michigan (USA) have discovered that these ancient retroviruses can undergo retrotransposition (DNA sequence insertion with RNA mediation) into iPS cells.

Released: 26-May-2022 12:00 PM EDT
Mesenchymal stem cell-derived exosomes: A novel and potential remedy for cutaneous wound healing and regeneration
World Journal of Stem Cells

Poor healing of cutaneous wounds is a common medical problem in the field of traumatology. Due to the intricate pathophysiological processes of wound healing, the use of conventional treatment methods, such as chemical molecule drugs and tradit

Released: 26-May-2022 12:00 PM EDT
Inhibition of glutathione metabolism can limit the development of pancreatic cancer
World Journal of Stem Cells

Pharmacological inhibitors of glutathione synthesis and circulation, such as buthionine-sulfoximine, inhibit glutathione metabolism. These drugs decrease the aggressiveness of pancreatic cancer, inhibit tumor stem cell survival, and reduce chem

Released: 26-May-2022 12:00 PM EDT
Human amniotic fluid stem cell therapy can help regain bladder function in type 2 diabetic rats
World Journal of Stem Cells

BACKGROUNDDiabetes mellitus (DM) is a serious and growing global health burden. It is estimated that 80% of diabetic patients have micturition problems such as poor emptying, urinary incontinence, urgency, and urgency incontinence. Patients wit

Released: 26-May-2022 12:00 PM EDT
Soluble factors secreted by human Wharton’s jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection: A mechanistic study with integrating network biology
World Journal of Stem Cells

BACKGROUNDHuman Wharton’s jelly-derived mesenchymal stromal/stem cells (hWJ-MSCs) have gained considerable attention in their applications in cell-based therapy due to several advantages offered by them. Recently, we reported that hWJ-MSCs an

Newswise: Internationally Renowned Cancer Researcher Joins Cancer Center’s Leadership Team
Released: 26-May-2022 11:05 AM EDT
Internationally Renowned Cancer Researcher Joins Cancer Center’s Leadership Team
UC Davis Comprehensive Cancer Center

UC Davis Comprehensive Cancer Center has a new chief science officer and associate director for basic science. Xiao-Jing Wang comes from the University of Colorado Anshutz Medical Campus where she focused on skin as well as head and neck cancers

Released: 25-May-2022 5:15 PM EDT
Double agents: How stomach stem cells change allegiance upon injury
Institute of Molecular Biotechnology

A stomach adult stem cell population can fulfill two distinct functions: either help with digestion under normal conditions or take the lead on injury response.

Newswise: New Hematology Chief and Director of the Wesley Center for Immunotherapy Named for University Hospitals Seidman Cancer Center
Released: 25-May-2022 2:30 PM EDT
New Hematology Chief and Director of the Wesley Center for Immunotherapy Named for University Hospitals Seidman Cancer Center
University Hospitals Cleveland Medical Center

Announcement of Koen van Besien, MD, PhD, being named leader of the new Wesley Center for Immunotherapy at University Hospitals Seidman Cancer Center in Cleveland, Ohio. He also will head the Division of Hematology.

Released: 25-May-2022 12:00 PM EDT
miR-582-5p regulates cell stemness and recurrence in bladder cancer via targeting CD81
Preprints

TianLei Xie, Zhongqing Zhang, Wenmin Cao, Wei Chen, Hongqian Guo, Junlong Zhuang

Released: 25-May-2022 12:00 PM EDT
Endometrial stem cell-derived exosomes repair cisplatin-induced premature ovarian failure via Hippo/YAP pathway
Preprints

Lijun Wang, Lihui Wang, Rongli Wang, Ting Xu, Jingyuan Wang, Zhiwei Cui, Feiyan Cheng, Wei Wang, Xinyuan Yang

Released: 25-May-2022 12:00 PM EDT
Lineage-Specific Differences and Regulatory Networks Governing Human Chondrocyte Development
Preprints

Daniel Richard, Steven Pregizer, Divya Venkatasubramanian, Pushpanathan Muthuirulan, Zun Liu, Terence D. Capellini, April M. Craft

Released: 24-May-2022 2:50 PM EDT
Stem Cell Cloning Experts Unraveling Cystic Fibrosis
University of Houston

Two nationally recognized experts in cloning and stem cell science from the University of Houston are taking the first step toward limiting the consequences of chronic inflammation in cystic fibrosis (CF) by identifying the source of this persistent and enigmatic inflammation in CF lungs.

Released: 24-May-2022 12:00 PM EDT
Body image in adolescent survivors of childhood cancer: the role of chronic health conditions
Preprints

Fabiën Belle, Tomáš Sláma, Christina Schindera, Tamara Diesch, Mutlu Kartal-Kaess, Claudia Kuehni, Luzius Mader

Released: 24-May-2022 12:00 PM EDT
Robust genome editing via modRNA-based Cas9 or base editor in human pluripotent stem cells
Preprints

Tahir Haideri, Alessandro Howells, Yuqian Jiang, Jian Yang, Xiaoping Bao, Xiaojun Lian

Released: 24-May-2022 12:00 PM EDT
A CRISPR-dCas13 RNA-editing tool to study alternative splicing
Preprints

Yaiza Nunez-Alvarez, Tristan Espie--Caullet, Reini F Luco

Released: 23-May-2022 12:00 PM EDT
Public Cord Blood Banks as a source of starting material for clinical grade HLA-homozygous induced pluripotent stem cells
Preprints

Belen Alvarez-Palomo, Anna Veiga, Angel Raya, Margarita Codinach, Silvia Torrents, Laura Ponce Verdugo, Clara Rodriguez-Aierbe, Leopoldo Cuellar, Raquel Alenda, Cristina Arbona, Dolores Hernández-Maraver, Cristina Fusté, Sergi Querol

Released: 23-May-2022 12:00 PM EDT
Evaluating the Safety and Efficacy of MSCs-derived Exosomes for Treatment of Resistant Perianal Fistula in IBD patients; Clinical Trial Phase I
Preprints

Hojjatollah Nazari, Asieh Heirani, Masoud Soleimani, Reza Akbari Asbagh, Behnam Behboudi, Mohammad Sadegh Fazeli, Mojgan Rahimi, Mohammad Reza Keramati, Amir Keshvari, Alireza Kazemeini, Foroogh Alborzi, Seyed Mohsen Ahmadi Tafti

Released: 23-May-2022 12:00 PM EDT
Acceptance of Murine Islet Allografts Without Immunosuppression in the Inguinal Subcutaneous White Adipose Tissue Pretreated with bFGF
Preprints

Yuki Nakafusa, Naoyoshi Nitta, Kazunari Ishii, Naoto Shirasu, Takahiro Iwamoto, Takayuki Nemoto, Masafumi Nakamura, Masafumi Goto, Hiroo Iwata, Masaru Taniguchi, Yohichi Yasunami

Released: 23-May-2022 12:00 PM EDT
Multiplexed Microfluidic Platform for Stem-Cell Derived Pancreatic Islet β Cells
Preprints

Ishan Goswami, Eleonora de Klerk, Phichitpol Carnese, Matthias Hebrok, Kevin Healy

Released: 23-May-2022 12:00 PM EDT
Characteristics of anti-CLL1 based CAR-T therapy for children with relapsed or refractory acute myeloid leukemia: the multi-center efficacy and safety interim analysis
Preprints

Min Luo, Hui Zhang, Chaoke Bu, Zhiyong Peng, Guangchao Li, Zhao Zhou, Wen Ding, Yongwei Zheng, Yingyi He, Zhengbin Hu, Kunlin Pei, Chunfu Li

Released: 20-May-2022 12:00 PM EDT
Carbonic anhydrase IX-targeted chemodynamic & photodynamic cancer stem cell therapy
Preprints

Hyo Sung Jung, Seyoung Koo, Miae Won, Seeun An, Haebeen Park, Jonathan Sessler, Jiyou Han, Jong Seung Kim

Released: 19-May-2022 12:00 PM EDT
Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model
Preprints

Sudip Paul, Masamitsu Sone, Ashwini Patil, Hisaya Kato, Yoshiro Maezawa, Motohiko Oshima, Masaki Fukuyo, Bahityar Rahmutulla, Yasuo Ouchi, Kyoko Tsujimura, Mahito Nakanishi, Atsushi Kaneda, Atsushi Iwama, Koutaro Yokote, Koji Eto, Naoya Takayama

Released: 19-May-2022 12:00 PM EDT
Mesenchymal Stromal Cells showed an alteration of differentiation potential under Environmental Micro and Nanoplastics Exposure
Preprints

Hana Najahi, Nicola Alessio, Tiziana Squillaro, Gea Oliveri Conti, Margherita Ferrante, Giovanni Di Bernardo, Umberto Galderisi, Imed Messaoudi, Sergio Minucci, Mohamed Banni

Released: 18-May-2022 12:00 PM EDT
Effects of a monoclonal antibody against (pro)renin receptor on gliomagenesis
Preprints

Takeshi Fujimori, Yuki Shibayama, Takahiro Kanda, Kenta Suzuki, Daisuke Ogawa, Ryo Ishikawa, Kyuichi Kadota, Toru Matsunaga, Keisuke Miyake, Akira Nishiyama, Takashi Tamiya

Released: 18-May-2022 12:00 PM EDT
High-throughput preclinical screening of CD123 scFv to design 3rd generation of CAR T-cell in the treatment of BPDCN patient
Preprints

Maxime Fredon, Margaux Poussard, Sabeha Biichle, Francis Bonnefoy, Evan Seffar, Elodie Bôle-Richard, Florian Renosi, Romain Boidot, François Anna, Maria Loustau, Julien Caumartin, Philippe Saas, Eric Deconinck, Etienne Daguindeau, Xavier Roussel, Olivier Adotevi, Fanny Angelot-Delettre, Jeanne Galaine, Francne Garnache-Ottou

Released: 17-May-2022 12:00 PM EDT
Downregulation of circBIRC6 and circCORO1C during differentiation of human cord blood-derived CD34 cells
Preprints

Roqaye Karimi, Amir Atashi, Mina Soufi Zomorrod, Monireh Agami, Mansoureh Ajami

Newswise: Can Spurring Neuron Growth in Adulthood Improve Cognitive Health, Mood?
Released: 16-May-2022 2:55 PM EDT
Can Spurring Neuron Growth in Adulthood Improve Cognitive Health, Mood?
University of North Carolina School of Medicine

UNC-Chapel Hill scientists boosted electrical activity between cells in the hypothalamus and the hippocampus to create new neurons – an important process called neurogenesis -- in animal models.

Released: 16-May-2022 12:00 PM EDT
A Label-Free Cell Sorting Approach to Highlight the Impact of Intratumoral Cellular Heterogeneity and Cancer Stem Cells on Response to Therapies
Preprints

Céline Hervieu, Mireille Verdier, Gaëlle Bégaud, Niki Christou, Magali Sage, Julie Pannequin, Serge Battu, Muriel Mathonnet

Released: 16-May-2022 8:35 AM EDT
Factor Bioscience to Deliver Four Presentations at the American Society of Gene & Cell Therapy (ASGCT) 25th Annual Meeting
Factor Bioscience

Factor Bioscience Inc., a Cambridge-based biotechnology company focused on developing mRNA and cell-engineering technologies, announced its participation in the American Society of Gene & Cell Therapy (ASGCT) 25th Annual Meeting to be held in Washington, D.C. from May 16-19, 2022.

Released: 16-May-2022 5:45 AM EDT
Efficacy of azacitidine in preventing relapse after hematopoietic stem cell transplantation for advanced myeloid malignancies: a systematic review and meta-analysis
Expert Review of Hematology

Background Relapse is the leading cause of death from myeloid malignancies after allogeneic hematopoietic stem cell transplantation (HSCT). Azacitidine has gained attention in recent years in the prophylaxis of relapsed refractory hematologic …

Released: 16-May-2022 5:45 AM EDT
Treosulfan plus fludarabine versus TEAM as conditioning treatment before autologous stem cell transplantation for B-cell Non-Hodgkin lymphoma
Bone Marrow Transplantation

Conditioning with treosulfan and fludarabine (Treo/Flu) has been proven to be feasible and efficient in several types of malignancies before allogeneic hematopoietic stem cell transplantation (allo-HSCT). Given its favorable reduced …

Released: 16-May-2022 5:45 AM EDT
The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
Oncogene

It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this …

Released: 16-May-2022 5:45 AM EDT
PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents
Cell Reports

… Given the important function of PTBP1 in directing lineage choice in diverse stem cell systems and the overall relevance of mRNA splicing in hematopoiesis, we hypothesized that PTBP1 might play a role as a regulator of posttranscriptional …

Released: 16-May-2022 5:45 AM EDT
T and NK Cells in IL2RG-Deficient Patient 50 Years After Hematopoietic Stem Cell Transplantation
Journal of Clinical Immunology

… To investigate the status of the T-cell compartment of UPN1 up to 51 years post-HSCT in the context of a stem cell boost at 37 years after HSCT, we aimed to combine detailed phenotyping with TCR repertoire analysis. Development of a T-cell-focused …

Released: 13-May-2022 5:45 AM EDT
Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders
Journal of Tissue Engineering

The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs development pipeline by mimicking the physiological environment and functions of human organs. The translational value of OoC is further enhanced when …

Released: 13-May-2022 5:45 AM EDT
Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival
Proceedings of the National Academy of Sciences (PNAS)

… for Atg5, the stem cell loss in vivo was more pronounced than in vitro, suggesting that additional cell populations likely depend upon Atg5 function to support ileum health. We first tested whether ATG5-dependent WNT signaling was required for …

Released: 13-May-2022 5:45 AM EDT
Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches
Nature Communications

… With Select-seq, we analyse the cancer stem cell-like microniches in relation to the tumour microenvironment of triple-negative breast cancer patients. We identify alternative splice variants, perform complementarity-determining region analysis of …

Released: 13-May-2022 5:45 AM EDT
Haematopoietic stem cell gene therapy in inborn errors of metabolism
British Journal of Haematology

Over the last 30 years, allogeneic haematopoietic stem cell transplantation (allo‐HSCT) has been adopted as a therapeutic strategy for many inborn errors of metabolism (IEM), due to the ability of donor‐derived cells to provide life‐long enzyme delivery to …

Released: 12-May-2022 12:00 PM EDT
Identification of potential crucial genes in sarcopenia: a bioinformatic analysis
Preprints

Youxiang Su, Nianhu Li, Jian Xin, Shang Gao, Yun Song, Xintian Qu, Yan Liu, Xiusen Ma

Released: 12-May-2022 5:00 AM EDT
Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia–reperfusion injure by restoring CPT1A mediated fatty acid oxidation
Stem Cell Research & Therapy

Renal fibrosis is a common pathological process of chronic kidney diseases induced by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance the efficacy of secreted extracellular vesicles (MSC-EVs) on various diseases, but it …


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