The Coriell Institute for Medical Research has been awarded a $9.2 million grant through an open competition from the National Institute of General Medical Sciences (NIGMS). This five-year award keeps Coriell in place as the steward of the NIGMS Human Genetic Cell Repository, a world-renowned collection of high quality cell lines and DNA samples representing genetic diseases, distinct human populations around the world, and more.
Los investigadores de Mayo Clinic descubrieron cuáles son los mecanismos de recuperación que las células madre activan después de un ataque cardíaco. Las células madre restablecieron el músculo cardíaco al estado que tenía antes del ataque al corazón, lo cual, a su vez, facilitó un diagrama del posible funcionamiento de estas células.
The regulators of apoptosis watch over cell replication and the decision to enter the cell cycle. Researchers now show a direct link between the protein MCL1 — a member of the BCL2 protein family known as the gatekeepers of apoptosis — and the cell-cycle checkpoint protein P18.
A new study from Washington University School of Medicine in St. Louis suggests that the age of certain immune cells used in immunotherapy plays a role in how effective it is. These cells — natural killer (NK) cells — appear to be more effective the earlier they are in development, opening the door to the possibility of an immunotherapy that would not utilize cells from the patient or a matched donor. Instead, they could be developed from existing supplies of what are called human pluripotent stem cells.
A team of University of California, Irvine researchers have published the first comprehensive overview of the major changes that occur in mammalian skin cells as they prepare to heal wounds. Results from the study provide a blueprint for future investigation into pathological conditions associated with poor wound healing, such as in diabetic patients.
The newly awarded $8.6 million funding keeps Coriell in place as the trusted steward of this collection and includes the addition of new innovative products to expand the collection. The NIA Aging Cell Repository was established at Coriell in 1974 and Coriell has continuously managed this unique resource ever since.