• In a study of 267 patients with chronic kidney disease, 69% of participants experienced at least one hazardous event related to their outpatient care. • Hypoglycemia (in patients with diabetes) and falling or severe dizziness (in patients without diabetes) were most frequently paired with other complications of medical care.
• Biopsy-detected injury in donated kidneys was modestly associated with a delay in organ function in the first week after transplantation, but only for donor kidneys already known to be at high risk. Donor kidney biopsies frequently underreported kidney injury with substantial variability. • There was a large degree of overlap between the results of biopsies from kidneys that were deemed unsuitable for transplantation and kidneys that were approved for transplantation. The quality of biopsies used in acceptance decisions was low.
• For pregnant women with kidney failure who underwent dialysis for more than 36 hours per week, the live birth rate was 85%, while it was only 48% in women dialyzed for 20 hours or less per week. • Infants were a healthier weight at birth when women were dialyzed for more than 20 hours per week than when women were dialyzed for 20 hours or less per week. • Pregnancy complications were few and manageable in patients receiving intensive dialysis.
The risk of a kidney donor developing kidney failure in the remaining organ is much lower than in the population at large, even when compared with people who have two kidneys, according to results of new Johns Hopkins research.
• Hospitalized patients who recovered from acute kidney injury had a 67% increased risk of experiencing coronary events or dying during a recent study. • Acute kidney injury’s harmful effects on heart health were comparable to those attributed to diabetes.
• Domoic acid accumulates in seafood and is toxic to the brain • The toxin damages kidneys at concentrations that are 100 times lower than what causes neurological effects.
Drug could help patients forgo toxic standard treatments that are often ineffective
• African-American dialysis patients with sickle cell trait received about 13% more of the medications used to treat anemia than other African-American patients to reach the same level of hemoglobin. • Sickle cell trait was slightly more common in African-American patients on dialysis (10%) than in the general African-American population (6.5% to 8.7%).
A new study by Joslin Diabetes Center researchers that compares the metabolic fingerprints of patients who develop ESRD versus those who don’t has furnished new clues to the disease.
Patients with chronic kidney disease who received robot-assisted partial nephrectomy to treat kidney cancer have minimal loss of kidney function -- a smaller amount even than patients with normal kidney function, according to researchers at Henry Ford Hospital’s Vattikuti Urology Institute.
• A single low dose of lithium given to mice following acute kidney injury promotes kidney repair and accelerates the recovery of kidney function.
• Putative kidney progenitor cells contribute to kidney function decline by causing kidney scarring. Targeting these cells may therefore help prevent or treat kidney failure. • Researchers have identified an additional but limited reserve of kidney filtering cells that are present at birth and become mature and functional filter cells by adulthood.
• Among women on chronic dialysis, sexual inactivity is common, with the most frequently described reasons being lack of interest in sex and lack of a partner. Rarely is sexual difficulty reported as a reason for lack of interest • Most women on chronic dialysis—including those lacking interest in sex—are satisfied with their sex lives.
• Even small amounts of physical activity can lead to up to a 31% decreased risk of developing kidney stones. • Eating more than 2200 calories per day may increase one’s risk of developing kidney stones by up to 42%.
• In individuals with moderate-to-severe kidney disease, those performing more than 150 minutes of physical activity per week had the lowest rate of kidney function decline. • Each 60-minute increment in weekly physical activity was linked with a 0.5% slower decline per year in kidney function.
Changes to a key protein amplified its natural ability to counter kidney disease, according to a study published today by researchers at the University of Alabama at Birmingham in the journal Nature Medicine.
A large study co-authored by Dominic Raj, M.D., director of the division of nephrology and professor of medicine at the GW School of Medicine and Health Sciences., identifies factors that mediate differences in the progression of chronic kidney disease in order to reduce the excess burden of end-stage renal disease and its complications in black patients.
Researchers found, in a genome-wide survey, significant differences in the pattern of chemical modifications on DNA that affect gene expression in kidney cells from patients with chronic kidney disease versus healthy controls. This is the first study to show that changes in these modifications – the cornerstone of the field of epigenetics – might explain chronic kidney disease.
• Most older adults initiate chronic dialysis in the hospital. • Those who have a prolonged hospital stay and receive other forms of life support around the time of dialysis initiation have limited survival and eventually need to undergo more intensive procedures.
An investigational, man-made blood vessel used in vascular grafts for kidney dialysis patients may potentially show encouraging early results among study patients in Poland, according to preliminary data reported Wednesday by a researcher at Duke Medicine.
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