Researchers at Duke Medicine and the University of Alberta are reporting the identification of a new biochemical pathway to control insulin secretion from islet beta cells in the pancreas, establishing a potential target for insulin control.
A new study has shown that for certain cancer drugs, participants in clinical trials are often not representative of the patients that ultimately take the drugs, raising questions about the direct applicability of trial data.
The UNC Lineberger Comprehensive Cancer Center’s application for renewal of a major five-year, federal grant earned an "exceptional" rating from the National Cancer Institute. The rating is the highest that a cancer center can earn for the application.
Scientists at Duke University have released a highly detailed model of connections in the mouse brain that could provide generations of neuroscientists new insights into brain circuits and origins of mental illness, such as depression and schizophrenia. The findings are published in the journal Cerebral Cortex.
A special series of articles addressing the ethical and regulatory challenges to pragmatic clinical trials appears this week on the website of the journal Clinical Trials. The 12 articles were sponsored by the NIH Health Care Systems Research Collaboratory with additional support from the Patient-Centered Outcomes Research Institute, and include authors drawn from the fields of clinical research and patient advocacy, as well as clinicians, bioethicists, and regulatory experts.
A $6 million federal grant, the largest ever awarded to Wake Forest University, will enable health and exercise science researchers to further study knee osteoarthritis and successful treatment measures in community-based settings.
Science faculty and the Learning Assistance Center (LAC) at Wake Forest University are collaborating this fall to help first-year students deal with test anxiety through a three-part workshop, “How to prevent a panic attack on your first college science exam.”
In a small pilot study, researchers from North Carolina State University have demonstrated a rapid, simple way to generate large numbers of lung stem cells for use in disease treatment.
Inside our bones there is fat. Diabetes increases the amount of this marrow fat. And now a study from the UNC School of Medicine shows how some diabetes drugs substantially increase bone fat and thus the risk of bone fractures.
The study, published in Nature Genetics, paves the way for potential personalized medicine approaches for the deadly cancer type.
A commonly prescribed antidepressant may alter brain structures in depressed and non-depressed individuals in very different ways, according to new research at Wake Forest Baptist Medical Center.
While much national media attention focuses on the moral failures of people in the public spotlight, a team of researchers at Wake Forest University has been awarded $3.9 million to search for moral superstars.
NC State linguist says language diversity isn't always celebrated on campus and calls dialect the "last acceptable personal trait to make fun of."
How did the ankylosaur get its tail club? According to research that traces the evolution of the ankylosaur’s distinctive tail, the handle arrived first on the scene, and the knot at the end of the tail followed.
Web-based survey finds "Bicyclists May Use Full Lane," more effective message for signs
A genetic test that helps predict whether some women’s breast cancer will recur might influence how chemotherapy is used, according to a study from Duke Medicine. The study found that low-risk patients who had the test appeared to opt for more treatment, and high-risk patients who were tested got less.
Female mice exposed in utero, or in the womb, to low levels of arsenic through drinking water displayed signs of early puberty and became obese as adults, according to scientists from the National Institutes of Health. The finding is significant because the exposure level of 10 parts per billion used in the study is the current U.S. Environmental Protection Agency standard, or maximum allowable amount, for arsenic in drinking water. The study, which appeared online August 21 in the journal Environmental Health Perspectives, serves as a good starting point for examining whether low-dose arsenic exposure could have similar health outcomes in humans.
Faculty in UNC Charlotte College of Health and Human Services have published a paper in the American Journal of Preventative medicine that outlines a novel approach to studying public health data.
Here’s one more reason to cut down on the amount of red meat you eat. Using an animal model, researchers at Wake Forest Baptist Medical Center have found that dietary iron intake, equivalent to heavy red meat consumption, suppresses leptin, a hormone that regulates appetite.
A new WFU study on archerfish and spitting prowess shows for first time that there is little difference in the amount of force of water jets based on target distance.
Female fish in the Bahamas have developed ways of showing males that “No means no.”
Metformin was introduced as a type-2 diabetes treatment decades ago, but researchers still debate how the drug works. A new study shows that metformin’s primary effect occurs in the gut, not the bloodstream. And a new version of the drug could help more people control their diabetes.
Every year falls affect approximately one in three older adults living at home, with approximately one in 10 falls resulting in serious injury. Even if an injury does not occur, the fear of falling can lead to reduced activity and a loss of independence. Research has shown that vitamin D plays a key role in maintaining muscle integrity and strength and some studies suggest vitamin D may reduce the risk of falls.
James Bear, PhD, uncovers the intricate mechanisms that allow certain cells to move, discoveries with implications for cancer metastasis.
The liver is unique among organs in its ability to regenerate after being damaged. Exactly how it repairs itself remained a mystery until recently, when researchers supported by the National Institutes of Health discovered a type of cell in mice essential to the process. The researchers also found similar cells in humans.
When fruit flies are attacked by parasites or bacteria they respond by producing offspring with greater genetic variability. These findings demonstrate that parents may purposefully alter the genotypes of their offspring to increase their chance of survival.
While MLK’s first “Dream” speech was played publicly for the first time Tuesday, it’s a speech King had been practicing since he was a teenager. A Wake Forest professor and his student identified striking parallels between the “Dream” speech and an address King delivered as a high school student.
In an article published in JAMA Oncology, a study led by a UNC Lineberger Comprehensive Cancer Center researcher and colleagues shows that a system they developed accurately and reliably captures the patient experience with cancer drug side effects.
To help teams keep infections to a minimum and players at their best, the Duke Infection Control Outreach Network has worked with the NFL and the NFL Players Association to develop a comprehensive reference manual for infection prevention, taking into account the highly contagious dynamics within a professional football team environment.
Charlotte charity Taylor’s Tale helped inspire a law designed to stimulate the creation of new treatments for rare diseases and spur economic development in North Carolina. House Bill 823, signed into law by Governor McCrory on August 6, will establish an Advisory Council on Rare Diseases within the School of Medicine of the University of North Carolina at Chapel Hill (UNC).
Last December, researchers identified more than 1,000 gene mutations in individuals with autism, but how these mutations increased risk for autism was unclear. Now, UNC researchers are the first to show how one of these mutations disables a molecular switch in one of these genes to cause autism.
Researchers from North Carolina State University show that magnetic nanoparticles encased in oily liquid shells can bind together in water, much like sand particles mixed with the right amount of water can form sandcastles.
Picky eating among children is a common but burdensome problem that can result in poor nutrition for kids, family conflict, and frustrated parents. Although many families see picky eating as a phase, a new study from Duke Medicine finds moderate and severe picky eating often coincides with serious childhood issues.
A recent HIV vaccine trial testing the HIV envelope as an immunogen was unsuccessful for protection against HIV infection. A new study has found that this vaccine selectively recruited antibodies reactive with both the HIV envelope and common intestinal microbes — a phenomenon previously reported by the same investigators to occur in the setting of acute HIV infection.
Scientists at the UNC School of Medicine and the UNC Lineberger Comprehensive Cancer Center found that a rare type of stem cell is immune to radiation damage thanks to high levels of a gene called Sox9.
Researchers at the National Institutes of Health have discovered a protein that plays a vital role in healthy egg-sperm union in mice. The protein RGS2 can delay an egg’s development into an embryo in order to allow time for sperm to arrive and merge with the egg in a healthy fertilization process. The embryo cannot survive without the male chromosomes.
The Histone Antibody Specificity Database (www.histoneantibodies.com), is a newly launched online portal that lets scientists find the right antibodies for their research with a much higher degree of confidence than ever before.
A new review article, published in the July 23, 2015 issue of The New England Journal of Medicine, analyzes the pros and cons of five different interventional approaches to gallbladder disease.
Sudden cardiac arrest kills an estimated 200,000 people a year in the United States, but many of those lives could be saved if ordinary bystanders simply performed CPR, a new study led by Duke Medicine shows. The early application of cardio-pulmonary resuscitation (CPR) by an average person nearby, combined with defibrillation by firefighters or police before the arrival of emergency medical services (EMS), was the one intervention that substantially increased survival from cardiac arrest, according to findings reported by Duke researchers and colleagues in the July 21 issue of the Journal of the American Medical Association.
Angelina Jolie received widespread media attention in 2013 when she told the public that she’d tested positive for BRCA1, a gene associated with an increased risk of breast cancer, and subsequently had a double mastectomy. Now research shows this publicity did influence some women’s intentions to seek similar testing.
College women who are more emotionally invested in Facebook and have lots of Facebook friends are less concerned with body size and shape and less likely to engage in risky dieting behaviors. But that’s only if they aren’t using Facebook to compare their bodies to their friends’ bodies, according to the authors of a surprising new study at the University of North Carolina School of Medicine.
In it's second annual ranking of best values among the nation's colleges and universities, Money magazine considered factors such as net price, graduation rate, and alumni earnings.
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