Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia

Newswise — Sebert, Gachet et al. analyzed longitudinal data from patients with Fanconi anemia, a rare inherited DNA-repair disease. They provided genomic and functional insights into MDM4-driven p53 response modulation yielding clonal hematopoiesis and preceding transformation to myeloid leukemia in the background of chromosomal instability and HSC attrition.