Decoding m⁶A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance

Newswise — Cheng et al. delineate a comprehensive m6A landscape during acute myeloid leukemia (AML) development and identify PRMT6, regulated by IGF2BP2, acting as a key for leukemia stem cell maintenance by restraining MFSD2A expression and docosahexaenoic acid levels. These findings provide the rationale for targeting PRMT6-MFSD2A signaling axis in AML therapy.