If mitigating racial disparities in those who contract pneumococcal diseases, such as meningitis and pneumonia, is a top public health priority, then recommending that all adults get a pneumococcal vaccine at age 50 would likely be effective guidance.
The vast majority of patients with neurodegenerative disorders do not have specific gene mutations, but a single misbehaving protein – called TDP-43 – seems to be at the heart of these diseases. Pitt researchers have found a way to recreate and rescue TDP-43 pathology in a dish.
New research shows that fluctuation and severity of depressive symptoms are much better at predicting risk of suicidal behavior in at-risk young adults.
A high proportion of multidrug-resistant tuberculosis (TB) cases can be cured in conflict-affected communities with molecular diagnostics, shorter treatment periods and socioeconomic incentives, according to the results of a large, long-term study in the Democratic Republic of Congo.
Researchers at the University of Pittsburgh School of Medicine have identified a brain protein at the root of how the brain recovers from stroke. The finding offers a promising avenue for developing therapies that could work even when given beyond the first few hours after a stroke.
Using super-sensitive microscopic imaging, a team of scientists made a fundamental biological discovery that explains the structure of the nuclear envelope and gives tantalizing clues as to how cells squish through narrow openings without springing a leak.
The higher a person’s immunity to dengue virus, the lower their risk of Zika infection, an international team of scientists led by the University of Pittsburgh Graduate School of Public Health, Yale School of Public Health and University of Florida report today in the journal Science.
Research in animal models suggest that liver cancers with a mutation in the β-catenin gene could respond to treatment with rapamycin, a commonly used immunosupressant.
Positive interactions on social media are not making young adults feel more connected, whereas negative experiences increase the likelihood of them reporting loneliness.
Researchers identified the brain circuits that form memories associating environmental cues with cocaine use and used optogenetics to specifically target those memories and reduce relapse-like behavior.
Pharmaceutical companies often cite R&D as the driver behind rising drug costs, but a new analysis shows that price inflation on older drugs is to blame.
Newly described mechanism called 'neuritosis' could play an important role in normal brain development, aging and neurodegenerative disease
Dr. Stephen Badylak among 148 academic innovators elected to the National Academy of Inventors.
The WHO considers Rift Valley fever a potential public health emergency. This study shows just how damaging the virus is during pregnancy and sets the stage for vaccine development.
Black patients with atrial fibrillation are significantly less likely to receive oral anticoagulants--particularly newer, more effective versions-- than white and Hispanic patients.
A protein found in healing muscles of younger mice helps older animals bounce back from injury.
People living in colder regions with less sunlight consume more alcohol and experience more alcoholic liver disease.
Previously incarcerated transgender women can find themselves caught in a cycle that leads to repeat jail time. A new analysis identifies potential solutions that could lead to transgender women being more successfully reintegrated into society.
The MidAtlantic AIDS Education and Training Center (MAAETC) will collaborate with UPMC and local HIV stakeholders to host an all-day educational forum to celebrate the 30th Anniversary of World AIDS Day and the 30th Anniversary of the MAAETC.
Nearly half of black teenagers surveyed in Allegheny County report losing a friend or family member to murder, a disproportionately stark statistic that is associated with suicide attempts and other negative childhood experiences.
Donald S. Burke, M.D., dean of the University of Pittsburgh Graduate School of Public Health and Distinguished University Professor of Health Science and Policy, today will receive the prestigious John Snow Award from the American Public Health Association and the Royal Society for Public Health.
UPMC-developed genetic test helps avoid preventable surgery, curb health care costs.
Progression free survival in triple-negative breast cancer increased when immunotherapy-chemotherapy treatment combination is used as the first treatment option.
E-cigarette brand JUUL’s Twitter handle is attracting adolescents to the point that at least a quarter of its followers appear to be under age 18. Many of these minors – to whom it is illegal to sell nicotine-delivery products – are retweeting JUUL’s messages, amplifying its advertisements.
Measuring the percentage of weight regained following the maximum amount of weight lost after bariatric surgery can help predict a patient’s risk of several serious health problems. The study also revealed that the rate of weight regained was highest in the first year following maximum weight loss.
Stiffness of the aorta – more so than blood pressure or subclinical brain disease – is a key risk factor for dementia. Since aortic stiffness can be reduced by medication and healthy lifestyle changes, these results suggest that people can still lower their dementia risk well into old age.
People who undergo Roux-en-Y gastric bypass surgery, a common type of bariatric surgery, are at an increased risk for alcohol-related problems. However, common screening tools that help physicians identify patients at high risk for alcohol use disorder fail to work well in this population.
The inaugural Magee Prize was awarded to Pitt's Dr. Yaacov Barak to research in how placental defects may lead to congenital heart defects.
A UPMC-developed test for diagnosis of thyroid nodules, ThyroSeq® Genomic Classifier, has been approved for coverage by its Medicare Administrative Contractor, Novitas Solutions. This decision paves the way for the test to be accessible to more than 50 million Medicare patients nationwide.
Three Pitt faculty members win highly selective NIH awards supporting high-risk, high-reward research projects
Sexual Harassment and Assault Linked to Worse Physical and Mental Health Among Midlife Women
A total of $475K in prizes was awarded to teams of budding entrepreneurs with the best ideas around improving human performance.
Findings from mouse study suggest organs affected by autoimmune disease suppress immune cells using methods similar to those used by cancer cells to evade detection.
The international summit will convene leaders in reproductive biology, precision medicine, public health and global health advocacy. The experts will share groundbreaking research and will culminate with crowdsourcing ideas on how to move women’s health to the forefront of medical research.
Death rates from drug overdoses in the U.S. have been on an exponential growth curve that began at least 15 years before the mid-1990s surge in opioid prescribing, suggesting that overdose death rates may continue along this same historical growth trajectory for years to come.
Children are at a considerable disadvantage when competing with adults for livers from deceased organ donors in the U.S. allocation system for liver transplants, a University of Pittsburgh Graduate School of Public Health-led analysis reveals today in JAMA Pediatrics.
It’s a longstanding mystery why salamanders can perfectly regenerate their tails whereas lizard tails grow back all wrong. By transplanting neural stem cells between species, Pitt researchers have discovered that the lizard’s native stem cells are the primary factor hampering tail regeneration.
As marine mammals evolved to make water their primary habitat, they lost the ability to make a protein that defends humans and other land-dwelling mammals from the neurotoxic effects of a popular man-made pesticide.
UPMC Presbyterian Hospital has been designated an Antimicrobial Stewardship Center of Excellence by the Infectious Disease Society of America (IDSA).
Caregiving resource will bring together decades of ongoing multidisciplinary research.
Two units of plasma given in a medical helicopter on the way to the hospital could increase the odds of traumatically injured patients with severe bleeding surviving by 10 percent, according to the results of a national clinical trial.
A gene linked to 3 to 4 percent of people with Parkinson’s disease could play an important role in most, if not all, people with the disease, according to a new study. The findings suggest that treatments being developed for this small group of people may benefit many more patients than previously thought.
More than one in 10 children hospitalized with sepsis die, but when a series of clinical treatments and tests is completed within an hour of its detection, the chances of survival increase considerably.
Postmenopausal factors may have an impact on the heart-protective qualities of high-density lipoproteins (HDL) – also known as ‘good cholesterol.’ The findings bring into question the current use of total HDL cholesterol to predict heart disease risk.
Several states are likely dramatically underestimating the effect of opioid-related deaths because of incomplete death certificate reporting, with Pennsylvania leading the pack.
New research from the University of Pittsburgh School of Medicine shows that white bloods cells, which typically heal infections and injuries, can become overactive and cause inflammation in plaques in blood vessels, making them vulnerable to rupture and hemorrhage in people with diabetes.
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