PHILADELPHIA – For their landmark research that set a foundation for the mRNA SARS-CoV-2 vaccines, Drew Weissman, MD, PhD, the Roberts Family Professor of Vaccine Research, and Katalin Karikó;, PhD, an adjunct professor of Neurosurgery at the Perelman School of Medicine at the University of Pennsylvania and a senior vice president at BioNTech, have been selected to receive the 2021 Albany Prize.
The United States’ longest-running NIH-sponsored musculoskeletal research center will receive $4M to continue its studies of everything from ligament tears to osteoarthritis
PHILADELPHIA – The U.S. Food and Drug Administration (FDA) has given the first full approval to a COVID-19 mRNA vaccine, which uses modified mRNA technology invented and developed by scientists in the Perelman School of Medicine at the University of Pennsylvania, whose years of research in mRNA science laid a critical piece of the foundation for the largest global vaccination campaign in history.
In one of the most comprehensive genome-wide association studies of its kind, Penn researchers have identified 182 genes likely responsible for kidney function — many of which can be targeted with existing drugs — and 88 genes for hypertension.
Messenger-RNA (mRNA) vaccines against the coronavirus that causes COVID-19 provoke a swift and strong response by the immune system’s T cells—the heavy armor of the immune system—according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania.
A new study from the Perelman School of Medicine at the University of Pennsylvania shows how to overcome resistance to CAR T cell therapy with an experimental small molecule inhibitor.
A new study shows that over a third of all members of Congress held health care-related assets with a median total value per member of over $43,000 between 2004 and 2014.
Penn Medicine hospitals have once again been ranked among the top in the nation by U.S News & World Report. The combined enterprise of the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center is ranked #13 in the nation on the magazine’s prestigious annual Honor Roll for the 15th consecutive year. HUP/PPMC is also ranked as the top hospital in Pennsylvania and #1 in the Philadelphia metro area.
To better coordinate health data projects across the health system and cement its status as a leader in informatics, Penn Medicine is launching a new hub center
Researchers have discovered a limitation of the immune system in battles against cancers or viruses: T cells remain programmed to stay exhausted even weeks after exposure to a virus ended. Scientists need to take this "T cell exhaustion” into account when devising immune-based therapies.
A new technology for cellular immunotherapy developed by Abramson Cancer Center researchers at Penn Medicine showed promising anti-tumor activity in the lab against hard-to-treat cancers driven by the once-considered “undruggable” KRAS mutation, including lung, colorectal, and pancreatic.
In Philadelphia, when a home received repairs through a city-funded program, total crime dropped by 21.9% on that block, and as the number of repaired houses on a block increased, instances of crime fell even further, according to research from the Perelman School of Medicine at the University of Pennsylvania published today in JAMA Network Open.
New research reveals that the same framework of proteins and peptides that can detect Alzheimer's disease in cerebrospinal fluid can also detect other forms of neurodegeneration, like frontotemporal degeneration.
The Cardio-Oncology Translational Center of Excellence at Penn Medicine has been awarded $2.9 million by the American Heart Association as part of a larger effort to reduce disparities in cardio-oncology and increase understanding of cardiovascular disease among cancer patients and survivors from minority populations. As part of this newly established research program, scientists from the University of Pennsylvania and other institutions will study patients with breast or prostate cancer, the most common cancers in women and men, respectively, with a focus on Black and Hispanic communities.
The Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania, the world’s first comprehensive center aimed at advancing research, treatment, and prevention of BRCA-related cancers, has announced Andre Nussenzweig, PhD, of the National Cancer Institute (NCI) as the recipient of the ninth annual Basser Global Prize. Nussenzweig serves as branch chief of the Laboratory of Genome Integrity in the NCI’s Center for Cancer Research.
Daily step counts increased by approximately 1,200 among veterans who were given goals and participated in game-like interventions with loss-framed cash rewards
Academic articles published by women in high-impact medical journals also have fewer citations than those written by men, especially when women are primary and senior authors, according to new research.
COVID-19 complicated patient care in a range of ways, from increased incidence of heart attacks to decreased cancer screenings. The virus also caused a six-fold increase in the risk of complications and death among trauma patients, according to new research.
Penn Medicine will continue its collaboration with the West and Southwest Philadelphia communities to operate a series of COVID-19 vaccine clinics in partnership with community organizations, faith-based institutions, restaurants, barbershops, and even professional sports teams thanks to $1 million in funding from the City of Philadelphia, in partnership with PMHCC.
The Hospital of the University of Pennsylvania (HUP) and Penn Presbyterian Medical Center (PPMC) rank #27 in the United States and #50 globally on Newsweek’s World’s Best Smart Hospitals 2021, which ranks the 250 best medical institutions that are leading the field in smart technologies, like digital surgery, imaging, artificial intelligence, telehealth and electronic medical records. Results are based on worldwide recommendations from medical professionals.
If Black patients were admitted to the same hospitals that serve a majority of White patients, researchers showed their risk of death would drop by 10 percent
Kellie A. Jurado, PhD, Presidential Assistant Professor of Microbiology, and Colin Conine, PhD, an assistant professor of Pediatrics and Genetics have been named 2021 Pew Scholars in the Biomedical Sciences. Liling Wan, PhD, an assistant professor of Cancer Biology joins the 2021 class of Pew-Stewart Scholars for Cancer Research.
An odor-based test that sniffs out vapors emanating from blood samples was able to distinguish between benign and pancreatic and ovarian cancer cells with up to 95 percent accuracy.
Antibodies aren’t the only immune cells needed to fight off COVID-19 — T cells are equally important and can step up to do the job when antibodies are depleted, suggests a new Penn Medicine study of blood cancer patients with COVID-19 published in Nature Medicine.
As many as one in three COVID-19 survivors experience a mental health or neurological disorder, adding to a growing body of evidence that show COVID-19 can have serious and potentially long-lasting effects on the brain. The Penn Neuro COVID Clinic aims to assess and treat long-haul COVID patients suffering from neurological symptoms.
Philadelphia-Based Top Academic Health System Becomes Nation’s Largest to Mandate Vaccination, Calling for Workforce to Set an Example to End the Pandemic
Penn Medicine CAREs awarded grants to 28 projects, many of which aim to fill vast needs in the community created by the COVID-19 pandemic, while others seek to improve diversity, equity, and inclusion.
A low-cost, rapid diagnostic test for COVID-19 developed by Penn Medicine provides COVID-19 results within four minutes with 90 percent accuracy. A paper published this week in Matter details the fast and inexpensive diagnostic test, called RAPID 1.0. Compared to existing methods for COVID-19 detection, RAPID is inexpensive and highly scalable, allowing the production of millions of units per week.
Statins are prescribed to less than half of eligible U.S. patients, and a new study shows time of day may affect doctors’ likelihood of writing a script
More than two-thirds of pancreatic cancer patients harboring genetic mutations saw their tumor stop growing or shrink substantially after being switched from intensive chemotherapy to the PARP inhibitor rucaparib as a maintenance therapy.
A gene called GAS2 plays a key role in normal hearing, and its absence causes severe hearing loss, according to a study led by researchers in the Perelman School of Medicine at the University of Pennsylvania.
Researchers used microscopy and machine learning to distinguish tau protein aggregates occurring as part of healthy functions from those occurring in disease
Program established at Penn Medicine to improve support for patients after emergency department visits, helping them recover at home instead of the hospital
The Pennsylvania Department of Health’s CURE program announced it will award a $3.5M grant to Penn Medicine researchers and community partners to address the underrepresentation of Black adults in Alszheimer’s Disease research. The grant supports the Aging Brain Cohort Dedicated to Diversity (ABCD2) study, a research and training initiative led by David Wolk, MD.
Penn Medicine and Children’s Hospital of Philadelphia (CHOP) will host a virtual event on May 6 and 7 that will bring together cell and gene therapy leaders from the two institutions and around the world to discuss the latest achievements in the field, novel strategies, and future developments and applications for chimeric antigen receptor, CAR, T cell therapy and more.
Altered neural functioning, like that experienced in patients with Parkinson’s disease, changes the way art is both perceived and valued. People with neurological motor dysfunction demonstrated decreased experiences of motion in abstract art and enhanced preferences for high-motion art, compared to a healthy control group.
Penn Medicine researchers discovered that less is more when it comes to the length of what is known as the single-chain variable fragment in CAR T cells.
Piperlongumine, a chemical compound found in the Indian Long Pepper plant, is known to kill cancerous cells in many tumor types. Now an international team including researchers from Penn has illuminated one way in which the piperlongumine works in animal models against glioblastoma.