Study Questions Certain Treatments for Diabetic Patients at High Risk for Heart Disease
American Society of Nephrology (ASN)• In patients with type 2 diabetes at high risk for cardiovascular disease, targeting blood sugar to normal levels (HbA1c<6.0%) reduced the risk for macroalbuminuria (a high amount of protein excreted in the urine) over an average follow-up of 7.7 years, but it had no impact on more significant kidney outcomes such as serum creatinine doubling (a marker of worsening kidney function) or the need for dialysis or transplantation. • Targeting low blood pressures (<120mmHg) or the use of fenofibrate to lower cholesterol increased the risk for doubling of serum creatinine, although it had no impact on the need for dialysis or transplantation.