Latest News from: Sanford Burnham Prebys Medical Discovery Institute

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Newswise: The secret to a long life? For worms, a cellular recycling protein is key
  • Embargo expired:
    11-Dec-2019 5:00 AM EST

The secret to a long life? For worms, a cellular recycling protein is key

Sanford Burnham Prebys Medical Discovery Institute

Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that worms live longer lives if they produce excess levels of a protein, p62, which recognizes toxic cell proteins that are tagged for destruction. The discovery, published in Nature Communications, could help uncover treatments for age-related conditions, such as Alzheimer’s disease, which are often caused by accumulation of misfolded proteins.

Channels: Aging, All Journal News, Cell Biology, Nature (journal), Grant Funded News,

Released:
10-Dec-2019 4:05 PM EST
Newswise: One-two punch drug combination offers hope for pancreatic cancer therapy

One-two punch drug combination offers hope for pancreatic cancer therapy

Sanford Burnham Prebys Medical Discovery Institute

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a combination of two anti-cancer compounds that shrank pancreatic tumors in mice—supporting the immediate evaluation of the drugs in a clinical trial. U.S. Food and Drug Administration (FDA)–approved versions of the compounds are used today to treat certain leukemias and solid tumors, including melanoma. The study was published in Nature Cell Biology.

Channels: All Journal News, Cancer, Clinical Trials, Pharmaceuticals, Digestive Disorders, Grant Funded News,

Released:
18-Nov-2019 11:00 AM EST
Research Results
Newswise: Sanford Burnham Prebys awarded $3.58 million NIH grant to advance potential treatment for opioid-use disorders
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    23-Oct-2019 8:00 AM EDT

Sanford Burnham Prebys awarded $3.58 million NIH grant to advance potential treatment for opioid-use disorders

Sanford Burnham Prebys Medical Discovery Institute

The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $3.58 million grant to Sanford Burnham Prebys scientist Anthony Pinkerton, Ph.D., to advance a potential treatment for opioid-use disorders, called SBI-553.

Channels: Addiction, All Journal News, Drugs and Drug Abuse, Public Health, Substance Abuse, National Institutes of Health (NIH),

Released:
21-Oct-2019 1:35 PM EDT
Research Results
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Machine Learning’s Next Frontier: Epigenetic Drug Discovery

Sanford Burnham Prebys Medical Discovery Institute

Scientists at Sanford Burnham Prebys Medical Discovery Institute have developed a machine-learning algorithm that gleans information from microscope images—allowing for high-throughput epigenetic drug screens that could unlock new treatments for cancer, heart disease, mental illness and more. The study was published in eLife.

Channels: All Journal News, Cancer, Cardiovascular Health, Cell Biology, Heart Disease, Mental Health, Pharmaceuticals, Grant Funded News, Artificial Intelligence,

Released:
22-Oct-2019 8:00 AM EDT
Announcement
Newswise: New Insights Into How to Protect Premature Babies From Common Brain Disorder
  • Embargo expired:
    9-Oct-2019 2:00 PM EDT

New Insights Into How to Protect Premature Babies From Common Brain Disorder

Sanford Burnham Prebys Medical Discovery Institute

Premature babies have delicate brain tissue that is prone to bleeding and can result in post-hemorrhagic hydrocephalus, a dangerous condition that leads to excess fluid accumulation and brain dysfunction. Now, scientists from Sanford Burnham Prebys Medical Discovery Institute have identified a new disease mechanism and potential molecular drug target that may protect premature newborns from developing the brain disorder. The study was published in Science Advances.

Channels: Cell Biology, Children's Health, Neuro, All Journal News, Grant Funded News,

Released:
8-Oct-2019 4:05 PM EDT
Research Results
Newswise: $4.96 Million CIRM Grant Awarded to Sanford Burnham Prebys to Help the Tiniest Patients

$4.96 Million CIRM Grant Awarded to Sanford Burnham Prebys to Help the Tiniest Patients

Sanford Burnham Prebys Medical Discovery Institute

The California Institute for Regenerative Medicine (CIRM) has awarded a $4.96 million grant to Sanford Burnham Prebys Professor Evan Y. Snyder, M.D., Ph.D. The funding will allow Snyder to complete pre-investigational new drug (IND)-enabling studies, a step toward securing U.S. Food & Drug Administration (FDA) approval of a human trial for neural stem cells as a potential treatment for newborns who experience oxygen and blood-flow deprivation during birth. Called perinatal hypoxic-ischemic brain injury (HII), the lack of oxygen and blood flow to the brain can cause cerebral palsy and other permanent neurological disorders.

Channels: Children's Health, Regenerative Medicine, Stem Cells, All Journal News,

Released:
19-Aug-2019 8:00 AM EDT
Research Results
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Sanford Burnham Prebys expands collaboration with Lilly to investigate immunological therapies

Sanford Burnham Prebys Medical Discovery Institute

Sanford Burnham Prebys Medical Discovery Institute today announced a three-year extension to its existing collaboration with Eli Lilly and Company (Lilly) to discover and develop immunological therapies. The goals of the agreement are to advance ongoing projects—including a Phase 1 clinical trial of an immune therapy that arose from the research collaboration—and to expand the previous scope to include omics-based target identification studies.

Channels: Autoimmune Diseases, Entrepreneurship, Immunology, Infectious Diseases,

Released:
14-Aug-2019 8:00 AM EDT
Announcement
Newswise: Functional Hair Follicles Grown from Stem Cells
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    27-Jun-2019 4:55 PM EDT

Functional Hair Follicles Grown from Stem Cells

Sanford Burnham Prebys Medical Discovery Institute

Scientists from Sanford Burnham Prebys have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry. The findings were presented today at the annual meeting of the International Society for Stem Cell Research (ISSCR) and received a Merit Award. A newly formed company, Stemson Therapeutics, has licensed the technology.

Channels: Cell Biology, Regenerative Medicine, Stem Cells, Medical Meetings,

Released:
25-Jun-2019 2:00 PM EDT
Announcement
Newswise: Nutritional Cues Regulate Pancreatic Tumor’s “Cell Drinking”
  • Embargo expired:
    27-Jun-2019 11:00 AM EDT

Nutritional Cues Regulate Pancreatic Tumor’s “Cell Drinking”

Sanford Burnham Prebys Medical Discovery Institute

Desperate for nutrients, rapidly growing pancreatic tumors resort to scavenging “fuel” through an alternative supply route, called macropinocytosis. Blocking this process, often described as “cellular drinking,” could lead to tumor-starving drugs. Now, scientists from Sanford Burnham Prebys have identified a signaling pathway that regulates macropinocytosis, the nutritional cue that triggers the process and key metabolic differences between tumors—revealing new directions for drug development and patient treatment. The findings were published in Developmental Cell.

Channels: Cancer, Cell Biology, All Journal News,

Released:
20-Jun-2019 4:55 PM EDT
Research Results
Newswise: ALS research reveals new treatment approach

ALS research reveals new treatment approach

Sanford Burnham Prebys Medical Discovery Institute

New research on amyotrophic lateral sclerosis (AML) has revealed that a protein called membralin plays a key role in the disease process. The study, published in Journal of Clinical Investigation, suggests that membralin-boosting gene therapy is a potential therapeutic direction to treat this often deadly disease.

Channels: All Journal News, Neuro, Grant Funded News,

Released:
23-May-2019 5:05 PM EDT
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