UCLA researchers are co-leading a new pre-clinical study that could prevent patients treated for cancer or osteoporosis from experiencing jawbone damage as a result of oral surgery.
A team of researchers at UCLA's Jonsson Comprehensive Cancer, Cedars-Sinai Cancer Center and Dana-Farber Cancer Institute have newly identified 34 genes that are associated with an increased risk for developing the earliest stages of ovarian cancer.
Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have been awarded a $4.6 million grant from the California Institute for Regenerative Medicine – also known as CIRM – to support a phase I clinical trial of a novel treatment for advanced sarcomas and other cancers with a specific tumor marker called NY-ESO-1.
UCLA researchers have developed a new artificial intelligence system to help radiologists improve their ability to diagnose prostate cancer. The system, called FocalNet, helps identify and predict the aggressiveness of the disease evaluating magnetic resonance imaging, or MRI, scans, and it does so with nearly the same level of accuracy as experienced radiologists.
FINDINGS UCLA researchers found that eliminating routine but unnecessary procedures before people undergo cataract surgery has the potential to save costs and resources for hospitals serving lower-income patients. Forgoing routine chest x-rays, electrocardiograms and other preoperative procedures — which studies have found to have no clinical benefit prior to cataract surgery — was associated with a savings of $67,241 over three years at one of the medical centers analyzed in the study.
In a study published online in Springer Nature, UCLA researchers have proven the impact of a new class of gene mutations on normal cellular biology. These mutations are in parts of the DNA that have only recently been discovered and shown to be powerful regulators in human biology. The mutation studied, called the KRAS-variant, has previously been shown to serve as a biomarker that can help people determine if they are at higher risk for certain cancers and also to help guide cancer treatment in KRAS-variant patients. The KRAS-variant is a germ-line mutation found in all cells and is passed from parents to their children.
Costs are on the rise for many kinds of medical treatments. UCLA researchers are looking for cost-effective ways to treat people who have locally advanced rectal cancer, a cancer located in the end section of the large intestine.
The Transplant Research and Education Center (TREC) at UCLA will launch the Living Donation Storytelling Project, a unique digital library of stories of people sharing their real experiences as living donors, recipients of living donor kidney transplants, and those in need of transplants.
In a new study published in the International Journal of Radiation Oncology, Biology, Physics, 160 articles about the usage of stereotactic body radiation or stereotactic ablative radio therapy were evaluated to determine the optimal dose to treat this cancer. The results of this study outline the recommended dose.
Measurements of hazardous air pollutant concentrations near operational sites have generally failed to capture levels above standard health benchmarks; yet, the majority of studies continue to find poor health outcomes increasing as distance from these operations decreases.
A preclinical study led by scientists at the UCLA Jonsson Comprehensive Cancer suggests that heating solid tumors during CAR T-cell therapy can enhance the treatment’s success.
A new study by UCLA researchers has found that female radiation oncologists submit fewer charges to Medicare, are reimbursed less per charge submitted and receive lower Medicare payments overall in comparison to male radiation oncologists.
A study has found that out-of-pocket health care spending and medical debt are substantially higher when adults have a history of adverse childhood experiences. The study showed that household medical costs were 30 percent higher, and the likelihood of medical debt was doubled, when an adult had lived through three or more adverse experiences during childhood.
FINDINGS The menopause transition, also known as perimenopause, is the time in a woman’s life when hormonal changes lead to irregular menstruation, hot flashes and other symptoms leading up to menopause, when menstruation stops altogether. The researchers found that women undergoing perimenopause lost lean body mass and more than doubled their fat mass.
Researchers from UCLA’s Jonsson Comprehensive Cancer Center have identified a possible new therapeutic strategy using two types of drug inhibitors at once to treat one of the world’s deadliest cancers.
FINDINGS Researchers found that more than 97 percent of the surgeries for appendicitis were laparoscopic, or minimally invasive, and most patients were discharged the same day or the next day. Only 3 percent of the procedures resulted in complications. Rates of unnecessary surgery — removing a “normal” appendix — were low (less than 4 percent), but were much higher in people without imaging studies before their operation (nearly 20 percent).
UCLA scientists have developed a new method to quickly screen hundreds of drugs in order to identify treatments that can target specific tumors.
Recognizing the persistence of health inequities in the Americas, an emerging Health Equity Network of the Americas (HENA) describes its approach to promoting health equity through intersectoral partnerships in a newly released issue of Ethnicity & Disease.
UCLA researchers have identified for the first time the origin of an immune cell that plays a critical role in the formation of healthy heart valves. The findings could pave the way for new treatments for heart valve disorders, which can be caused by congenital defects, aging or disease. Their study, led by Dr. Atsushi “Austin” Nakano, a UCLA associate professor of molecular, cell and developmental biology and member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, was published in the journal Developmental Cell.
UCLA neuroscientists found that patients born without a gene called CCR5 recover better from mild stroke. Published in Cell, the discovery could lead to the first pill to reverse the physical and mental aftermath of the disease.
Colorectal cancer is one of the most common cancers in both men and women – but it needn’t be. Oncologist Zev Wainberg, MD, debunks four common myths about the disease.
Music therapists at UCLA Mattel Children's Hospital worked with a family with triplets to test whether a pacifier device playing a lullaby recorded by parents helps premature babies learn skills vital to feeding
UCLA researchers have found that people involved in electric scooter accidents are sometimes injured badly enough — from fractures, dislocated joints and head injuries — to require treatment in an emergency department. The researchers examined data from 249 people who were treated at the emergency departments of UCLA Medical Center, Santa Monica, and Ronald Reagan UCLA Medical Center between Sept.
Music therapists at UCLA worked with families with premature infants, including a family with triplets, to study whether a lullaby device can help newborns born early develop the skills necessary for feeding
A UCLA-led study suggests that for people with recurrent glioblastoma, administering an immunotherapy drug before surgery is more effective than using the drug afterward.
The E. Richard Brown Symposium will be held on March 1st and will focus on universal health care in California.
A new UCLA-led study shows that men with low- or intermediate-risk prostate cancer can safely undergo higher doses of radiation over a significantly shorter period of time and still have the same, successful outcomes as from a much longer course of treatment.
The murder rate in Mexico increased so dramatically between 2005 and 2015 that it partially offset expected gains in life expectancy among men there, according to a new study by a UCLA public health researcher.
A study by UCLA researchers is the first to demonstrate a technique for coaxing pluripotent stem cells — which can give rise to every cell type in the body and which can be grown indefinitely in the lab — into becoming mature T cells capable of killing tumor cells.
UCLA researchers led by Dr. Donald Kohn have created a method for modifying blood stem cells to reverse the genetic mutation that causes a life-threatening autoimmune syndrome called IPEX.
Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered that squamous cell skin cancers do not require increased glucose to power their development and growth, contrary to a long-held belief about cancer metabolism. The findings could bring about a better understanding of many cancers' metabolic needs and lead to the development of more effective therapies for squamous cell skin cancer and other forms of epithelial cancer.
FINDINGS Emergency medical personnel in Alameda County, California, use a screening process for determining whether to “medically clear” patients experiencing psychiatric emergencies before transporting them. They identify patients who are at low risk for medical emergencies and take them directly to a special psychiatric emergency service facility specifically designed for people experiencing psychiatric crises.
A new study by UCLA scientists shows that enhancers, snippets of DNA that contribute to gene regulation, fall into the same “insulated neighborhoods” or chromatin loops as the target gene and other gene-specific regulatory elements.
Two studies have linked DNA changes to their molecular effects in the brain, revealing new mechanisms for psychiatric diseases. The findings provide a roadmap for developing a new generation of therapies for conditions like autism, schizophrenia and bipolar disorder.
By age 12 to 18 months, 6.25% of children exposed to Zika during their mothers’ pregnancies had eye abnormalities, 12.2% had hearing problems, and 11.7% had severe delays in language, motor skills and/or cognitive function. In all, 14.5% had at least one of the three abnormalities.
Many people who are diagnosed with cancer will undergo some type of surgery to treat their disease — almost 95 percent of people with early-diagnosed breast cancer will require surgery and it’s often the first line of treatment for people with brain tumors, for example. But despite improvements in surgical techniques over the past decade, the cancer often comes back after the procedure.
Few governments make pre-primary education available on a tuition-free basis for two or more years, according to a new study from the WORLD Policy Analysis Center.
A UCLA-led research team has identified genetic processes involved in the neurodegeneration that occurs in dementia — an important step on the path toward developing therapies that could slow or halt the course of the disease. The findings appear Dec. 3 in the journal Nature Medicine.
Opioid use in Mexico has been low, but national and international factors are converging and a threat of increased drug and addiction rates exists. Many of these factors may have originated in the U.S., making this a potential joint U.S.-Mexico epidemic.
UCLA researchers have found that commonly used hormone therapies for women diagnosed with breast cancer do not appear to cause significant cognitive dysfunction following the treatment.
The study, led by UCLA professors Claudio Scafoglio and David Shackelford, suggests that a biomarker can help scientists detect lung cancer earlier, when it is much easier to treat.
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