The Influenza IMPRINT Cohort study will explore the emerging idea that a person’s very first influenza virus exposure impacts the magnitude, durability and breadth of their immune response to all future flu exposures.
Although KJ Upshaw’s official job title at Cincinnati Children’s is floor tech in Environmental Services, he refers to himself simply as the housekeeper. For two little boys in the medical center’s Bone Marrow Transplant unit, KJ is much more. He’s a cherished friend who helped make their lives in the hospital brighter and more fulfilling.
A study in Nature shows stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to enhance the mechanical properties of the injured area.
After decades of little or no progress, biomedical researchers are finally making some headway at detecting and treating sepsis, a deadly medical complication that sends a surge of pathogenic infection through the body and remains a major public health problem. They report data in Science Translational Medicine.
Bariatric surgery can be a life-changer for severely obese teens. However, some recipients may develop nutritional deficiencies years after treatment. Also, one of the two primary forms of bariatric surgery, gastric bypass, appears to cause more nutritional disruption than the other, vertical sleeve gastrectomy, according to study led by experts at Cincinnati Children’s published online Nov. 8, 2019 in the journal Clinical Gastroenterology and Hepatology.
A study led by experts at Cincinnati Children's reports new details about a rare lung complication affecting children with systemic JIA. The complications appear related to how some patients react to treatments called "biologics."
In a finding that could help lead to new therapies for immune diseases like multiple sclerosis and IBD, scientists report in the Journal of Experimental Medicine identifying a gene and family of proteins critical to the formation of mature and fully functioning T cells in the immune system.
Young adult women with a documented history of being maltreated as children report higher levels of pain than women not maltreated in childhood, according to a new study.
Cincinnati Children's will use a $28M federal grant to serve as the data coordinating center for the Rare Diseases Clinical Research Network. The network includes 20 groups of medical centers searching for improved treatments for hundreds of rare diseases.
The mehealth web portal for ADHD can support a physician’s selection of behavioral medications, appropriate dosing and testing of other interventions.
Three new studies by scientists at Cincinnati Children’s, in collaboration with researchers at the University of Cincinnati, highlight the relationship between air pollution and mental health in children.
Building upon the initial five-year plan, LungMAP 2 includes research on normal lung development in early adulthood and abnormal development in selected rare lung diseases.
Targeting the protein Eyes Absent 3 (EYA3) may help prevent vascular remodeling in pulmonary arterial hypertension (PAH), according to new study from Cincinnati Children's.
Researchers used a powerful new computer-assisted technology called single-cell transcriptomics that measures thousands of individual cells simultaneously to map cell types and molecular cascades that drive the growth of SHH-medulloblastoma. In a study published Aug. 29 by the journal Cancer Cell
In a study based on mouse models, scientists at Cincinnati Children's reveal that NK cell transplants may help reduce the risk of severe bleeding during childbirth caused by placental accreta.
Clinical trials are a critical tool for getting new treatments to people who need them, but research shows that difficulty finding the right volunteer subjects can undermine the effectiveness of these studies. Researchers designed and tested a new computerized solution that used artificial intelligence (AI) to effectively identify eligible subjects from Electronic Health Records (EHRs), allowing busy clinical staff to focus their limited time on evaluating the highest quality candidates
Scientists created human pancreas on a chip that allowed them to identify the possible cause of a frequent and deadly complication of cystic fibrosis (CF) called CF-Related Diabetes, or CFRD. It may be feasible to also use the small two-chambered device, which features bioengineered human pancreatic organoids to study the causes of non-CF-related conditions such as type 1 and 2 diabetes, according to researchers who report findings in Nature Communications.
Researchers suggest a possible cell-based therapy to stimulate lung development in fragile premature infants who suffer from a rare condition called Bronchopulmonary Dysplasia (BPD), which in the most severe cases can lead to lifelong breathing problems and even death. Scientists publish their preclinical findings report the American Journal of Respiratory and Critical Care Medicine.
Scientists used a gene editing method called CRISPR/Cas9 to generate mice that mimic a respiratory disorder in newborn infants that turns their lips and skin blue. The new laboratory model allowed researchers to find the ailment’s cause and a potential, desperately needed nanoparticle-based treatment.
June 19 is World Sickle Cell Awareness Day. Scientists at Cincinnati Children's have recently made three important steps forward in helping people with sickle cell in the U.S. and in sub-Saharan Africa live longer, better lives.
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