Researchers have created a machine-learning algorithm that can pick up on subtle signs of osteoarthritis – too abstract to register in the eye of a trained radiologist – on an MRI scan taken years before symptom onset.
People with atrial fibrillation who are exposed to greater levels of pollution have a higher risk of stroke than their peers who live with less pollution.
The slight decline in drug overdose deaths in 2018 coincides with Chinese regulations on the powerful opioid carfentanil, rather than the result of domestic U.S. efforts to curb the opioid epidemic, a University of Pittsburgh Graduate School of Public Health analysis revealed today.
Scientists announced today that they have isolated the smallest biological molecule to date that completely and specifically neutralizes the SARS-CoV-2 virus, which is the cause of COVID-19.
The $1 million Magee Prize will support a collaborative team whose groundbreaking research in reproductive sciences and women’s health could improve lives globally.
Researchers created a system that uses CRISPR in a new way. Rather than acting on the genome to create permanent change, their system briefly suppresses genes specific to adenovirus antibody production, just long enough for the virus to deliver its gene therapy cargo unimpeded.
The FDA just revoked their EUA for intubation boxes - plastic shields that supposedly protect health care workers from becoming infected with SARS-CoV-2 - due to concerns over aerosol leaks. This study describes a better box, with negative pressure and filtration, that contains airborne virus.
Contrary to earlier observational results, vitamin D supplements do not prevent severe asthma attacks in at-risk children, according to the first placebo-controlled clinical trial to test this relationship.
Hepatocytes – the chief functional cells of the liver – are natural regenerators, and the lymph nodes serve as a nurturing place where they can multiply. Researchers demonstrated that large animals with ailing livers can grow a new organ in their lymph nodes from their own hepatocytes.
Men at particular risk for HIV are very likely to consistently take prevention medication during vacations when their odds of contracting the virus are higher, according to a new study.
In the first large, multicenter analysis of its kind, the 40-hospital UPMC health system today reported its findings on clinician-directed retesting of patients for presence of SARS-CoV-2, the virus that causes COVID-19.
New research by neuroscientists at the University of Pittsburgh and UC San Francisco (UCSF) revealed that a simple, earbud-like device developed at UCSF that imperceptibly stimulates a key nerve leading to the brain could significantly improve the wearer’s ability to learn sounds of a new language.
Study finds that men who harbor more harmful attitudes about masculinity – including beliefs about aggression and homophobia – also tend toward bullying, sexual harassment, depression and suicidal thoughts.
Study reports 98% sensitivity and 97% specificity in recognizing and characterizing prostate cancer using an artificial intelligence (AI) program.
Critics of the universal hepatitis C screening argue that it’s wasteful to test pregnant women for a disease that can’t be immediately treated, but results of a small phase I clinical trial suggest otherwise: pregnancy could be an excellent time to diagnose and cure hepatitis C infection.
Devices commonly implanted for chronic pain could expand patient access to prosthetic arms that "feel."
New study on how immune memory can be targeted and improve immunotherapy and prevent cancer recurrence.
Infusing umbilical cord blood – a readily available source of stem cells – safely and effectively treated 44 children born with various non-cancerous genetic disorders, including sickle cell, thalassemia, Hunter syndrome, Krabbe disease, MLD, and an array of immune deficiencies.
The National Institutes of Health has renewed a five-year grant for $5 million for the Alliance for Regenerative Rehabilitation and Training (AR3T) to continue its work expanding scientific knowledge, expertise and methodologies focused on science and regenerative medicine.
Mice that received an injection of a new experimental drug, TAT-DP-2, after a stroke had smaller areas of damage, and their long-term neurological function was better than that of untreated animals.
Using skin cells from human volunteers, researchers at the University of Pittsburgh School of Medicine have created fully functional mini livers, which they then transplanted into rats. In this proof-of-concept experiment, the lab-made organs survived for four days inside their animal hosts.
A multidisciplinary team of clinicians and researchers led by UPMC Sports Medicine has developed guidelines to assist coaches, athletic trainers and organizers creating a safe environment for youth athletes, fans and staff as they consider a return to play.
Using rabies virus injected into the stomach of rats, researchers trace the nerves back to the brain and find distinct "fight or flight" and "rest and digest" circuits. These results explain how mental states can affect the gut, and present new ways to treat gastrointestinal problems.
A new discovery in mice shows the innate immune system has "memory," previously thought to be a unique feature of the adaptive immune system. Blocking this memory prevented transplanted organs from being rejected, providing a way to more specific drugs that could lengthen organ transplant survival.
The generation a person was born into – Silent Generation, Baby Boomer, Generation X or Millennial – strongly predicts how likely they are to die from a drug overdose, and at what age. Within each generation, there was a steady march toward greater overdose risk at younger ages.
Through serendipity, researchers at the University of Pittsburgh Graduate School of Public Health considerably reduced the toxicity of a potential antibiotic against the most feared drug-resistant bacteria, while also improving its stability in fighting infections.
Novel 'learning while doing' clinical trial approach called REMAP helps doctors find the optimal trade-off between quickly adopting new therapies during a pandemic, such as the anti-malarial drug hydroxychloroquine, and waiting until they are tested in longer clinical trials. The trial announced today at UPMC, called UPMC-REMAP-COVID19 learns from similar trials enrolling around the world and uses artificial intelligence to quickly arrive at answers.
A potential COVID-19 vaccine, delivered by microscopic needles, produces antibodies specific to the virus when tested in mice. This is the first peer-reviewed paper describing a COVID-19 vaccine candidate. The next step is a human clinical trial.
UPMC is implementing a staffing and pay protection program, which will ensure that all staff will continue to be paid at their current rate for normally scheduled hours through May 9, 2020 even if they are assigned to alternative work during their regular hours.
Inspired by a tactic cancer cells use to evade the immune system, University of Pittsburgh researchers have engineered tiny particles that can trick the body into accepting transplanted tissue as its own, while leaving the immune system intact.
Researchers from seven institutions team up to create a device combining artificial intelligence, bioelectronics and regenerative medicine for regrowing muscle tissue, especially after combat injuries.
The net cost of prescription drugs – meaning sticker price minus manufacturer discounts – rose over three times faster than the rate of inflation over the course of a decade, according to a study published today in JAMA. It’s the first to report trends in all brand name net drug costs in the U.S.
Although 1 in 7 adults smoke cigarettes the year prior to undergoing weight-loss surgery, nearly all successfully quit at least a month before their operation. However, smoking prevalence steadily climbs to pre-surgery levels within seven years, according to new research.
Researchers surveyed 153 transgender youths receiving gender-affirming care at a specialty clinic, and even in this relatively "out" population, nearly half reported intentionally hiding their gender identity from a health care provider outside the clinic.
During a press briefing Friday at AAAS, Dr. Rory Cooper will discuss how people with disabilities are shut off from STEM careers and why inclusivity matters.
A marker for heart disease risk considerably worsens as women transition through menopause, according to a new analysis from the largest and longest running study of women’s health in midlife. Black women experience this accelerated decline earlier in menopause than their white counterparts.
Nearly 2 of every 5 women of reproductive age in the U.S. live in counties where Catholic hospitals have a high market share, according to a new analysis. Catholic hospitals do not provide certain reproductive health options.
University of Pittsburgh researchers have created a biodegradable nerve guide – a polymer tube – filled with growth-promoting protein that can regenerate long sections of damaged nerves, without the need for transplanting stem cells or a donor nerve.
Advanced stage cancer diagnoses declined following health insurance expansion in Massachusetts, likely due to increased access to screening and diagnostic services that identified cancers earlier, according to new research.
Overweight and obese vitamin D-deficient children who took a relatively high dose of vitamin D every day for six months had lower blood pressure and improved insulin sensitivity than their peers who took a lower dose, according to the results of a new clinical trial.
Commercially insured children in the U.S. are seeing pediatricians less often than they did a decade ago, according to a new analysis led by a pediatrician-scientist at the University of Pittsburgh and UPMC Children’s Hospital of Pittsburgh.
Twice as many people as previously believed are dying of sepsis worldwide, according to an analysis published today in The Lancet and announced at the Critical Care Reviews annual meeting in Belfast. Among them are a disproportionately high number of children in poor areas.
A study involving tens of thousands of bariatric surgery patients found that gastric bypass patients were significantly more likely than gastric sleeve patients to end up back in the hospital in the years following surgery.
UPMC is the first center in the U.S. to implant a wireless retinal device to treat advanced age-related macular degeneration.
Coaching Boys Into Men, a program that seeks to prevent dating violence and sexual assault, reduces abusive behaviors among middle school male athletes toward their female peers, according to clinical trial results published today in JAMA Pediatrics.
Worldwide, more people die from tuberculosis than any other infectious disease, even though the vast majority were vaccinated. The vaccine just isn’t that reliable. But a new Nature study finds that simply changing the way the vaccine is administered could dramatically boost its protective power.
Teenage boys who witness their peers abusing women and girls are much more likely to bully and fight with others, as well as behave abusively toward their dates, compared to teenage boys who don’t witness such behaviors, according to a new study.
People in rural areas of the U.S. who receive subsidies to buy health insurance in the Health Insurance Marketplaces pay less in premiums than their counterparts in urban areas, a flip that occurred in 2018 and has been widening since, according to a new analysis.
Epigenetic disorders are more common among children born through assisted reproductive technology. A new mouse study suggests that the fertility treatments themselves are to blame, not the age of the mother.
A qualitative study by researchers at the University of Pittsburgh School of Medicine found that women in their 60s report various reasons behind why they lack libido – including sexual dysfunction in their partners.
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