The University of Pittsburgh School of Dental Medicine is the first in the nation to establish opioid-free pain management guidelines for the vast majority of procedures performed in all of its clinics.
Using U.S. transplant registry data, clinical researchers at the University of Pittsburgh found that kidney transplants between identical twins have high success rates, but also surprisingly high rates of immunosuppressant use.
Physicians who received gifts from pharmaceutical companies related to opioid medications were more likely to prescribe opioids to their patients in the following year, according to a new analysis.
How bacteria live – whether as independent cells or in a communal biofilm – determines the course of their evolution, with implications for drug-resistant infections.
New research led by scientists at the University of Pittsburgh Graduate School of Public Health and published today in the journal Obstetrics & Gynecology is beginning to establish evidence-based guidelines for maternal weight gain while pregnant with twins.
The first comprehensive look at the immune system of the fetal gut shows that it is far more developed before birth, and could help develop new maternal vaccines and understand if we are predisposed to autoimmune diseases before birth.
Surgery can mend congenital heart defects shortly after birth, but those babies will carry a higher risk of heart failure for the rest of their lives. UPMC Children’s Hospital researchers found that β-blockers could supplement surgery to mitigate the lasting effects of congenital heart disease.
The health care market is failing to support new antibiotics used to treat some of the world’s most dangerous, drug-resistant “superbugs,” according to a new analysis by University of Pittsburgh School of Medicine infectious disease scientists.
To guide the emerging practice of using video as an integral part of the scientific process, University of Pittsburgh Graduate School of Public Health scientists performed the first review of studies on use of film in public health research.
In March 2016, the Organ Procurement and Transplantation Network revised its criteria for prioritizing children awaiting heart transplantation in the U.S. with the intention of reducing the number of deaths on the waitlist, but a new study suggests unintended consequences.
UPMC Children's Hospital researchers find that the presence of adult social support is linked to less violence among at-risk teen boys.
America has the highest maternal mortality rate in the developed world. Since cardiovascular disease is the primary cause, researchers have created a blood pressure home-monitoring system to rapidly detect concerning trends in postpartum women before their situation becomes critical.
One out of every five tweets mentioning JUUL indentified for a new analysis also references addiction-related themes.
Targeted damage to mitochondria produces a "Chernobyl effect" inside cells, pelting the nucleus with harmful reactive oxygen species and causing chromosomal damage.
In a decade, Medicare recipients saw a sevenfold increase in out of pocket costs for multiple sclerosis drugs. Spending on these drugs by Medicare itself increased by tenfold.
New, more effective antibiotics are being prescribed in only about a quarter of infections by carbapenem-resistant Enterobacteriaceae (CRE), a family of the world’s most intractable drug-resistant bacteria.
Critically ill children brought to hospital emergency departments that are ill-prepared to care for pediatric emergencies have more than three times the odds of dying compared to those brought to hospitals well-equipped to care for them.
The growing number of children arriving at Texas schools unvaccinated makes the state increasingly vulnerable to measles outbreaks. A 5% further decrease in vaccination rates that have been on a downward trend since 2003 would increase the size of a potential measles outbreak by up to 4,000%.
There is a dearth of scientifically investigated, evidence-based interventions to address substance use, mental health problems and violence victimization in sexual and gender minority youth, according to new research.
Researchers studying schizophrenia-affected brains have discovered that the daily timing of gene expression is highly disrupted in the region responsible for cognition and memory. The findings could help reveal previously missed genetic links to the disease.
One out of four sepsis patients who survive their hospital stay have elevated levels of inflammation a year after discharge, and they are at higher risk for major health problems and death.
In a proof-of-concept paper, Pitt researchers chronicle how they transformed genetically engineered human cells into functional, 3D liver tissue that mimics non-alcoholic fatty liver disease (NAFLD) – a condition involving fat buildup in the liver, which can lead to cirrhosis or even liver failure.
One young transgender woman was able to produce viable sperm after a few months of discontinuing her puberty-halting medication, whereas a second case wasn’t able to produce sperm during the time she could tolerate being off her medication.
A study from the University of Pittsburgh Graduate School of Public Health shows that using an estradiol patch was associated with accumulation of fat around the heart and worsening of coronary artery calcification.
A surprising new discovery in mouse models reveals a previously unknown role for pain in immunity and has implications for treating autoimmune diseases
Using single-molecule imaging, researchers witness how molecules find and fix damaged DNA
Death rates from sepsis fell faster in New York than expected – and faster than in peer states – following the introduction of the nation’s first state-mandated sepsis regulation.
Even after nearly a decade of strict HIV treatment, cells sheltering the virus could be found in the cerebrospinal fluid of half of participants in a national clinical trial of people living with HIV. Moreover, those participants had higher likelihood of cognitive deficits.
New research from UPMC and Pitt shows that living-donor liver transplant offers numerous advantages over deceased-donor transplant, including superior outcomes and less resource utilization.
New study analyzed 2 million birth records and 3,000 cancer registry records and found that children born to obese mothers were 57% more likely to develop cancer, independent of other factors. This finding offers a rare opportunity for childhood cancer prevention.
Patients with sickle cell disease experience severe organ damage leading to early death. An international clinical trial funded by the NIH will test whether red cell exchange, which replaces sicked red blood cells with normal ones could prevent or reverse organ damage and prolong life.
By dispensing a year's worth of birth control pills up front, the VA could prevent 583 unintended pregnancies and save $2M per year on health care costs each year.
A move by the White House in 2017 – decried by many health policy analysts as an attempt to undercut the Affordable Care Act – had unanticipated consequences that improved the affordability of health insurance for Marketplace enrollees.
The University of Pittsburgh School of Medicine and UPMC will lead nearly two dozen emergency medical service agencies across the country in a Department of Defense (DOD)-funded clinical trial aimed at improving survival among people who have difficulty breathing after a trauma.
People who receive opioids for the first time while hospitalized have double the risk of continuing to receive opioids for months after discharge compared with their hospitalized peers who are not given opioids. The findings are among the first to shed light on in-patient opioid prescribing.
Human and mouse experiments show that an antibody in breastmilk is necessary to prevent necrotizing enterocolitis – an often deadly bacterial disease of the intestine.
The faster fluid is removed using continuous dialysis from patients with failing kidneys, the higher the likelihood they will die in the next several months, according to a study published today in JAMA Network Open by University of Pittsburgh School of Medicine researchers.
The death rate from drug- and alcohol-related causes in people who’ve had Roux-en-Y gastric bypass surgery is nearly triple that of the general public, according to University of Pittsburgh research published today in Surgery for Obesity and Related Diseases.
The University of Pittsburgh School of Medicine and Carnegie Mellon University have each been awarded 4-year contracts totaling nearly $7.5 million from the U.S. Department of Defense to create an autonomous trauma care system that fits in a backpack and can treat and stabilize soldiers injured in
Backed by a five-year, $6.7 million National Institutes of Health grant, the University of Pittsburgh today announced that it plans to lead a culture shift in data-sharing rippling through scientific fields and harness it to improve global knowledge of infectious diseases.
Reversibly paralyzing and heavily sedating hospitalized patients with severe breathing problems do not improve outcomes in most cases, according to a clinical trial conducted at dozens of North American hospitals. The trial settles a long-standing debate in the critical care medicine community.
Much like cancer, sepsis isn’t simply one condition, but rather many conditions with varying clinical characteristics that could benefit from different treatments, according to a study involving more than 100,000 patients. The findings could explain why several recent clinical trials have failed.
First causal evidence that oxidative stress works directly on telomeres to speed cellular aging
Children with HIV are much more susceptible to TB and also much more likely to die from it. This grant will fund international research to investigate why, both in the lab and in the field.
Reactive neurostimulation reduces seizure frequency by remodeling the brain, and early electrical signatures of this process could be used to accelerate and personalize treatment.
Children with acute respiratory infections were prescribed antibiotics more often during direct-to-consumer telemedicine visits than during in-person primary care appointments or urgent care visits, according to UPMC Children’s Hospital of Pittsburgh research reported today in Pediatrics.
In the years following bariatric surgery, a person’s overall eating behaviors and the amount of time spent watching television, playing video games and using a computer are a better indication of long-term weight loss success than specific weight control practices like counting calories.
In a first on the quest to cure HIV, University of Pittsburgh scientists report that they’ve developed an all-in-one immunotherapy approach that not only kicks HIV out of hiding in the immune system, but also kills it. The key lies in immune cells designed to recognize an entirely different virus.
In a first, researchers at the University of Pittsburgh School of Medicine and the Magee-Womens Research Institute have reported in a non-human primate model that immature testicular tissue can be cryopreserved, and later be used to restore fertility to the same animal.
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