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Newswise: Access matters: lack of resources is associated with increased mortality in childhood cancer survivors
8-Feb-2023 4:00 PM EST
Access matters: lack of resources is associated with increased mortality in childhood cancer survivors
St. Jude Children's Research Hospital

St. Jude Children’s Research Hospital researchers find increased risk of mortality in childhood cancer survivors is associated independently with local poverty, chronic conditions and frailty.

Newswise: Detect minor clones in blood cells: St. Jude looks deep to find source of accelerated aging in childhood cancer survivors
7-Feb-2023 6:05 PM EST
Detect minor clones in blood cells: St. Jude looks deep to find source of accelerated aging in childhood cancer survivors
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital used deep sequencing data from childhood cancer survivors and found the mutational fingerprint of a toxic chemotherapy associated with a marker of accelerated aging.

Newswise: St. Jude scientists create more efficient CAR immunotherapies using a molecular anchor
Released: 2-Feb-2023 2:15 PM EST
St. Jude scientists create more efficient CAR immunotherapies using a molecular anchor
St. Jude Children's Research Hospital

St. Jude scientists added a small physical structure called an anchor domain to the CAR molecule. The anchor domain connects the CAR to the internal infrastructure of the immune cell. It augments and helps organize the immune synapse

   
Newswise: Thirumala-Devi Kanneganti, Ph.D. named 2022 AAAS Fellow
Released: 31-Jan-2023 5:05 PM EST
Thirumala-Devi Kanneganti, Ph.D. named 2022 AAAS Fellow
St. Jude Children's Research Hospital

Immunologist recognized for her achievements in the field of innate immunity, developing new concepts in inflammasome biology and inflammatory cell death, PANoptosis.

Newswise: St. Jude names leading researcher as new chair of oncology department
Released: 26-Jan-2023 10:00 AM EST
St. Jude names leading researcher as new chair of oncology department
St. Jude Children's Research Hospital

Julie R. Park, M.D. to succeed longtime chair Ching-Hon Pui, M.D.

   
Newswise: Pioneering approach advances study of CTCF protein in transcription biology
25-Jan-2023 2:00 PM EST
Pioneering approach advances study of CTCF protein in transcription biology
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital used the auxin-inducible degron 2 system on CTCF, bringing the novel approach to bear on a fundamental protein.

   
Newswise: Structural insights reveal how SPOP protein contributes to cancer
22-Jan-2023 11:00 AM EST
Structural insights reveal how SPOP protein contributes to cancer
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital captured the 3D structure of SPOP, revealing how mutations in previously unappreciated regions fuel cancer.

Newswise: Pharmacotyping of childhood leukemia provides a blueprint for ‘true precision medicine’
4-Jan-2023 5:30 PM EST
Pharmacotyping of childhood leukemia provides a blueprint for ‘true precision medicine’
St. Jude Children's Research Hospital

Scientists from St. Jude Children’s Research Hospital performed the largest study yet examining drug sensitivity in childhood acute lymphoblastic leukemia across genomic subtypes and its association with treatment response.

Newswise: Space and time influence G-protein coupled receptor interactions
Released: 5-Dec-2022 3:55 PM EST
Space and time influence G-protein coupled receptor interactions
St. Jude Children's Research Hospital

By simulating molecular dynamics, scientists from St. Jude Children’s Research Hospital revealed how the selectivity or promiscuity of GPCR coupling relies on the location and duration of intermolecular interactions.

Newswise: Model demonstrates how RNA splicing defects contribute to Alzheimer’s disease
Released: 13-Oct-2022 2:40 PM EDT
Model demonstrates how RNA splicing defects contribute to Alzheimer’s disease
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital created a model to study the role of RNA splicing defects in Alzheimer’s disease, revealing degeneration and toxicity caused by neuron hyperexcitability.

Newswise: Three of the World’s Top Research Institutions Join Forces to Drive Progress Against Pediatric Cancer
Released: 13-Oct-2022 6:00 AM EDT
Three of the World’s Top Research Institutions Join Forces to Drive Progress Against Pediatric Cancer
St. Jude Children's Research Hospital

Large-scale collaboration will leverage each institution’s expertise and infrastructure to advance understanding of the biological basis of pediatric cancers, identify new vulnerabilities of these diseases and accelerate cures globally.

   
Newswise: A link between hypoxia and fetal hemoglobin provides hope for sickle cell disease
Released: 12-Oct-2022 11:05 AM EDT
A link between hypoxia and fetal hemoglobin provides hope for sickle cell disease
St. Jude Children's Research Hospital

St. Jude Children’s Research Hospital scientists found the cellular response to low oxygen also increases fetal hemoglobin expression in adults, which could lead to novel treatments for some common genetic anemias.

Newswise: Findings explain exceptional auditory abilities in Williams-Beuren Syndrome
Released: 23-Sep-2022 11:00 AM EDT
Findings explain exceptional auditory abilities in Williams-Beuren Syndrome
St. Jude Children's Research Hospital

Scientists from St. Jude Children's Research Hospital identified the mechanism by which the disorder enhances the ability to discriminate between sounds as interneuron hyperexcitability in the auditory cortex.

Newswise: St. Jude finds a new way to identify ‘safe harbor’ for gene therapies
Released: 22-Sep-2022 5:05 PM EDT
St. Jude finds a new way to identify ‘safe harbor’ for gene therapies
St. Jude Children's Research Hospital

St. Jude scientists have created a tool that can find safe places to put corrected genes into the genome, called safe harbor sites, using genomic and epigenetic information from specific tissue, such as blood cells.

Newswise: Rhombic lip implicated in origins of high-risk medulloblastoma
Released: 21-Sep-2022 11:00 AM EDT
Rhombic lip implicated in origins of high-risk medulloblastoma
St. Jude Children's Research Hospital

Scientists from St. Jude Children’s Research Hospital found that group 3 and 4 medulloblastoma arise from the rhombic lip, knowledge that may help improve research models and therapeutic development.

Newswise: St. Jude Comprehensive Cancer Center receives Merit Extension Award from NCI
Released: 16-Sep-2022 1:45 PM EDT
St. Jude Comprehensive Cancer Center receives Merit Extension Award from NCI
St. Jude Children's Research Hospital

The St. Jude Comprehensive Cancer Center award extends its current $35 million, five-year Cancer Center Support Grant (CCSG) for an additional two years.

Newswise: Family ties: Inherited genetic variants increase risk of Hodgkin lymphoma
Released: 8-Sep-2022 1:00 PM EDT
Family ties: Inherited genetic variants increase risk of Hodgkin lymphoma
St. Jude Children's Research Hospital

Large populations studies have previously demonstrated that Hodgkin lymphoma occurs in families, pointing to a likely genetic predisposition that makes these families more likely to develop this cancer.

Newswise: A Near-Death Experience Worsens Some Cancer Cells
Released: 1-Sep-2022 2:05 PM EDT
A Near-Death Experience Worsens Some Cancer Cells
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital discovered how some cancer cells survive treatment and cause cancer to recur, along with a potential way to stop the process.

Newswise: To wipe childhood cancer off the map, scientists must chart its genomic landscape
Released: 1-Sep-2022 12:45 PM EDT
To wipe childhood cancer off the map, scientists must chart its genomic landscape
St. Jude Children's Research Hospital

Scientists at St. Jude sequenced more samples of the most common childhood cancer than ever before to fully characterize the potential mutations driving disease.

Newswise: SAFER Ukraine provides a blueprint for responding to global health crises
Released: 31-Aug-2022 12:00 PM EDT
SAFER Ukraine provides a blueprint for responding to global health crises
St. Jude Children's Research Hospital

Russia’s invasion of Ukraine created a dire situation for children with cancer and blood disorders. In response, the St. Jude Global initiative of St. Jude Children’s Research Hospital banded together with international partners and formed SAFER Ukraine. An account appears in The Lancet Haematology.



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