Scientists at St. Jude Children’s Research Hospital solved the 3D structure of a protein in cilia, an organelle important to many diseases at nearly ten times the resolution of previous efforts.
St. Jude Children’s Research Hospital researchers find increased risk of mortality in childhood cancer survivors is associated independently with local poverty, chronic conditions and frailty.
Scientists at St. Jude Children’s Research Hospital used deep sequencing data from childhood cancer survivors and found the mutational fingerprint of a toxic chemotherapy associated with a marker of accelerated aging.
St. Jude scientists added a small physical structure called an anchor domain to the CAR molecule. The anchor domain connects the CAR to the internal infrastructure of the immune cell. It augments and helps organize the immune synapse
Immunologist recognized for her achievements in the field of innate immunity, developing new concepts in inflammasome biology and inflammatory cell death, PANoptosis.
Julie R. Park, M.D. to succeed longtime chair Ching-Hon Pui, M.D.
Scientists at St. Jude Children’s Research Hospital used the auxin-inducible degron 2 system on CTCF, bringing the novel approach to bear on a fundamental protein.
Scientists at St. Jude Children’s Research Hospital captured the 3D structure of SPOP, revealing how mutations in previously unappreciated regions fuel cancer.
Scientists from St. Jude Children’s Research Hospital performed the largest study yet examining drug sensitivity in childhood acute lymphoblastic leukemia across genomic subtypes and its association with treatment response.
By simulating molecular dynamics, scientists from St. Jude Children’s Research Hospital revealed how the selectivity or promiscuity of GPCR coupling relies on the location and duration of intermolecular interactions.
Scientists at St. Jude Children’s Research Hospital created a model to study the role of RNA splicing defects in Alzheimer’s disease, revealing degeneration and toxicity caused by neuron hyperexcitability.
Large-scale collaboration will leverage each institution’s expertise and infrastructure to advance understanding of the biological basis of pediatric cancers, identify new vulnerabilities of these diseases and accelerate cures globally.
St. Jude Children’s Research Hospital scientists found the cellular response to low oxygen also increases fetal hemoglobin expression in adults, which could lead to novel treatments for some common genetic anemias.
Scientists from St. Jude Children's Research Hospital identified the mechanism by which the disorder enhances the ability to discriminate between sounds as interneuron hyperexcitability in the auditory cortex.
St. Jude scientists have created a tool that can find safe places to put corrected genes into the genome, called safe harbor sites, using genomic and epigenetic information from specific tissue, such as blood cells.
Scientists from St. Jude Children’s Research Hospital found that group 3 and 4 medulloblastoma arise from the rhombic lip, knowledge that may help improve research models and therapeutic development.
The St. Jude Comprehensive Cancer Center award extends its current $35 million, five-year Cancer Center Support Grant (CCSG) for an additional two years.
Large populations studies have previously demonstrated that Hodgkin lymphoma occurs in families, pointing to a likely genetic predisposition that makes these families more likely to develop this cancer.
Scientists at St. Jude Children’s Research Hospital discovered how some cancer cells survive treatment and cause cancer to recur, along with a potential way to stop the process.
Scientists at St. Jude sequenced more samples of the most common childhood cancer than ever before to fully characterize the potential mutations driving disease.
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