New study suggests that readily available PET scanning could enable a whole-body analysis of the effects of systemic STING-activating therapy in humans, potentially providing a diagnostic tool to guide clinical development of this treatment approach.
Fast data processing of overdose deaths, which have increased in recent years, is crucial to developing a rapid public health response. But the system now in place lacks precision and takes months. To correct that, UCLA researchers have developed an automated process that reduces data collection to a few weeks.
The four-year award, part of the NIH’s BRAIN Initiative, will support the design, manufacturing and distribution of two types of new "miniscopes" that will allow scientists to peer much deeper into the brain than before.
New research led by UCLA Jonsson Comprehensive Cancer Center investigators suggests that new technology in development may lead to a better way to detect early-stage hepatocellular carcinoma (HCC).
UCLA researchers and colleagues at Emory University and other research centers have combined data simulation and experimental observation to bridge a gap between two major properties of large-scale organization of the human brain – stationary and traveling waves of activity.
UCLA Health is joining a new effort to increase the ability to quickly respond to emerging pathogens by creating the capability to detect all existing and new respiratory RNA viruses in a single test.
The inaugural cohort of innovators has been selected to participate in UCLA Health’s new TechQuity Accelerator.
Key takeaways: • Just like the real thing. The stem cell–derived interneurons, which play a role in sensations like touch and pain, are indistinguishable from their real-life counterparts in the body. • Tomorrow’s therapies. In addition to potential treatments for injury-related sensation loss, the discovery could lead to new methods for screening drugs for chronic pain. • Moving forward. While stem cells from mice were used in the research, scientists are now working to replicate the findings with human cells.
Peer comparison, a commonly used behavioral intervention comparing primary care physicians' performance to that of their peers, has no statistically significant impact on preventive care performance. It does, however, decrease physicians’ job satisfaction while increasing burnout.
UCLA has received a $59 million Clinical and Translational Science Award from the National Center for Advancing Translational Sciences (NCATS). The five-year award supports the UCLA Clinical and Translational Science Institute (CTSI), a research partnership among UCLA, Charles Drew University of Medicine and Science, the Lundquist Institute at Harbor-UCLA Medical Center, and Cedars-Sinai Medical Center.
A unique study of brain activity in the cerebral cortex of epilepsy patients found there was a robust response to sound during sleep that largely mirrored the brain’s response during wakefulness. However, there was one key difference from wakefulness.
A UCLA study offers the first evidence that transgender patients who receive gender-affirming facial feminization surgery reported better mental health after their procedures.
Outpatient antibiotic management of selected patients with appendicitis is safe, allowing many patients to avoid surgery and hospitalization, and should be considered as part of shared decision-making between doctor and patient.
HIV has an “early and substantial” impact on aging in infected people, accelerating biological changes in the body associated with normal aging within just two to three years of infection.
Medicare could waste up to $605 million per year on the controversial Alzheimer’s drug aducanumab if it is eventually approved for widespread use because it is supplied in vials containing fixed doses that may not be appropriate for all patients–resulting in the trashing of large volumes of unused drug
Doctors at the UCLA Gender Health Program have developed a technique to reduce an Adam’s apple bump without leaving a scar on the patient’s neck.
A new study from UCLA researchers indicates a previously undocumented impact of the promotion of Covid-19 vaccines on other public health behaviors. Adult flu vaccination rates have declined in states with low rates of Covid-19 vaccination, which the authors say may be a harbinger of declining trust in public health and could make some populations more vulnerable to preventable disease.
A research team led by UCLA’s Anusha Kalbasi, MD, has shown that a synthetic IL-9 receptor allows cancer-fighting T cells to do their work without the need for chemotherapy or radiation.
A new study in mice finds that a gene therapy developed by a UCLA researcher appears to correct a rare creatine deficiency disorder that commonly results in intellectual disabilities, problems with speech, involuntary movements and recurrent seizures.
A new study in mice by UCLA scientists reveals how exposure to traffic-related air pollutants causes cellular changes in the placenta that can lead to pregnancy complications and affect the health of both mother and offspring.
New UCLA research published in The Journal of Physiology points to a novel treatment for respiratory depression associated with opioid use that administers electrical pulses to the back of the neck, helping patients regain respiratory control following high dosage opioid use. This could offer an alternative to pharmacological treatments, which can cause withdrawal symptoms, heart problems and can negatively affect the central nervous system.
One powerful way cancer cells defend against tumor-killing immune cells is to load up their cell surface with a protein known as PD-L1. Now a team of UCLA Jonsson Comprehensive Cancer Center researchers led by Roger S. Lo, MD, PhD, has identified a method to degrade tumor cell-surface PD-L1, thereby making tumors susceptible to immune attack.
A new UCLA study has identified a gene on the Y chromosome that protects against pulmonary hypertension – a rare but fatal disease that occurs four times more often in women than men.
Data from 44 hospitals in 26 states show that suicide or self-injury and depressive disorders were the primary mental health reasons children received emergency department (ED) or hospital inpatient care after statewide school closures were enacted during the first part of the COVID-19 pandemic.
UCLA researchers have taken the initial step in identifying what may be an effective way to detect gestational diabetes mellitus (GDM) earlier in pregnancy, potentially improving diagnosis and treatment for what is the most common disorder of pregnancy.
UCLA scientists have discovered how the brain links memories and a way to restore this function in aging mice--as well as an FDA-approved drug that achieves the same thing. The Nature findings suggest a new method for combatting middle-aged memory loss.
In states with bans on affirmative action programs, the proportion of students from underrepresented racial and ethnic minority groups in U.S. public medical schools fell by more than one-third by five years after those bans went into effect.
A new Supplement released today in the journal Pediatrics suggests that although we are starting to connect the dots between events and experiences early in life and later adult health challenges, we are not doing nearly enough to intervene in childhood to optimize later health outcomes.
Researchers studying the effect of the monoclonal antibody Leronlimab on long COVID-19 may have found a surprising clue to the baffling syndrome, one that contradicts their initial hypothesis. An abnormally suppressed immune system may be to blame, not a persistently hyperactive one as they had suspected.
New UCLA research finds that 30% of people treated for COVID-19 developed Post Acute Sequelae of COVID-19 (PASC), most commonly known as “Long COVID.”
A report from the Autism Intervention Research Network on Physical Health (AIR-P), a multi-site collaboration housed within UCLA Health’s Department of Medicine, highlights the intersection of autism, poverty and race/ethnicity and their compounding impact on health and health care.
The rate of overdose deaths among U.S. teenagers nearly doubled in 2020, the first year of the COVID pandemic, and rose another 20% in the first half of 2021 compared with the 10 years before the pandemic, even as drug use remained generally stable during the same period.
For a recent six-year period, the injury rate for riders of electric scooters in one section of Los Angeles was higher than the national rates for riders of motorcycles, bicycles and cars, and pedestrians.
A new study led by researchers at UCLA has shown that a specialized primary care medical home improved the care and treatment of patients with serious mental illness, resulting in better mental health-related quality of life.
A new study led by UCLA Health scientists shows highly creative people’s brains appear to work differently from others', with an atypical approach that makes distant connections more quickly by bypassing the “hubs” seen in non-creative brains.
The National Institute of Mental Health has renewed its support for UCLA’s collaborative Center for HIV Identification, Prevention and Treatment Services, or CHIPTS, with a five-year, $7.5 million grant.
psychedelics may find new, legitimate roles in treatment for anxiety, depression, stress disorders, addiction, and other mental and behavioral health problems. But ensuring they do requires developing rigorous, standardized methods to study and apply the results, according to a new report.
The Dementia Care Study (D-CARE), a nation-wide clinical trial assessing the effectiveness of different approaches to caring for people with Alzheimer’s disease and other dementias, has reached its recruitment goal by enrolling 2,176 persons living with dementia and their caregivers
Researchers say the challenges of treating long COVID are amplified by a critical issue: we do not know what constitutes long COVID or how to formally diagnose it, an issue that is further exacerbated by limited research data of varying quality and consistency.
Researchers at UCLA Health have found that Housing First, a national program to provide housing and support for homeless persons, was effective in helping homeless veterans access housing and remain in their homes five years after it was implemented.
In 2020, the first year of the COVID-19 pandemic, the rate of drug overdose deaths among Black Americans surpassed that of whites for the first time since 1999 — a sharp reversal of the situation a decade earlier, when rates were twice as high for whites as for Blacks.
Analyzing breast-cancer tumors with artificial intelligence has the potential to improve healthcare efficiency and outcomes, but doctors should proceed cautiously, according to a new editorial in JAMA Health Forum co-written by Dr. Joann G. Elmore, a researcher at the UCLA Jonsson Comprehensive Cancer Center.
UCLA Health, in partnership with BioscienceLA and UCLA Biodesign, has launched a new accelerator at the intersection of health equity and technology. Aimed at supporting long-term community health resilience and improvements in the aftermath of the COVID-19 pandemic, the UCLA Health TechQuity Accelerator seeks to bridge clinical excellence and innovation for diverse patient populations.
UCLA researchers presented today the first case of a U.S. woman living with HIV-1 that is in remission after she received a new combination of specialized stem cell transplants for treatment of acute myeloid leukemia (AML). The oral abstract was presented at CROI 2022, the Conference on Retroviruses and Opportunistic Infections.
An interim analysis of an ongoing Phase III study from UCLA Jonsson Comprehensive Cancer Center indicates that using magnetic resonance imaging (MRI) to guide precisely-focused high-dose radiation treatment for prostate cancer reduced side effects associated with the treatment. The findings are being presented at the 2022 ASCO Genitourinary (GU) Cancers Symposium in San Francisco, Calif.
A newly launched UCLA Space Medicine Fellowship, the first of its kind in the U.S., aims to develop the next generation of flight surgeons who will support the health, safety, and well-being of human space flight and planetary expeditions.
A team led by UCLA researchers will receive a multi-million dollar grant to study why some people suffer from a devastating fungal infection called Valley Fever, while others suffer seemingly no impact from the disease.
Investigators from UCLA Jonsson Comprehensive Cancer Center have identified a germline biomarker signature that successfully predicts which patients will suffer serious side effects that occur in up to three in 10 patients on anti-PD1/PDL1 therapy, a promising new approach to treating cancer.
Researchers at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA and the David Geffen School of Medicine at UCLA have developed a new mouse model of Huntington’s disease, providing new clues to the disease and giving researchers a powerful new tool to test new therapies engaging multiple targets.
Neuroscientists at the David Geffen School of Medicine at UCLA in collaboration with scientists at UC Berkeley have discovered that visual stimulation not only guides the way brain cells connect, but actually influences the types of cells that form in the first place – something that was thought to be genetically programmed.
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