Scientists at The Scripps Research Institute (TSRI) have found a way to change leukemia cells into leukemia-killing immune cells. The surprise finding could lead to a powerful new therapy for leukemia and possibly other cancers.
Researchers at The Scripps Research Institute in California, USA, and two German institutes, the Center for Integrated Psychiatry Kiel and the Fraunhofer Institute for Molecular Biology and Applied Ecology IME, have announced a partnership to advance the quality control of human stem cells.
Matthew Disney, a professor on the Florida campus of The Scripps Research Institute, has won the 2016 Tetrahedron Young Investigator Award for Bioorganic and Medicinal Chemistry, a distinction recognizing a scientist who have exhibited "exceptional creativity and dedication."
Matthew Disney, a professor on the Florida campus of The Scripps Research Institute has been awarded the National Institutes of Health’s prestigious 2015 Pioneer Award. The award enables scientists to develop groundbreaking approaches with a significant impact on broad areas of biomedical science.
A new study led by scientists at The Scripps Research Institute shows that a technology used in thousands of laboratories, called gas chromatography mass spectrometry, fundamentally alters the samples it analyzes.
Scientists from the Florida campus of The Scripps Research Institute have uncovered a significant—and potentially treatable—relationship between a chemical that helps transmit signals in the brain and genetic mutations present in a subset of individuals with autism spectrum disorder.
In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) describe a class of compounds with the potential to stop chronic itch without the adverse side effects normally associated with medicating the condition.
Scientists from the Florida campus of The Scripps Research Institute have been awarded up to nearly $6 million dollars from the Bill & Melinda Gates Foundation to develop a revolutionary HIV/AIDS alternative vaccine that has demonstrated great potential in animal models.
The National Science Foundation has awarded more than $1.5 million to Lisa Stowers, associate professor at The Scripps Research, to support research using 1,000 odor molecules.
A new study from The Scripps Research Institute has shown that a specific molecule controls morphine receptor signaling in a small group of brain cells. The findings could lead to a new drug target for developing less-addictive pain medications.
The Scripps Research Institute (TSRI) today announced the appointment of chemist Peter G. Schultz as CEO and biologist Steve A. Kay as President.
Drawing on complementary strengths of two San Diego institutions, The Scripps Research Institute and the University of California, San Diego have formed a new consortium with a big mission: to map cells in space and time.
The Scripps Research Institute announced today that it has received a $5.65 million gift from Helen Dorris, a San Diego mental health advocate and founder of TSRI’s Dorris Neuroscience Center.
Scientists at The Scripps Research Institute have received a grant of nearly $4.5 million—with the possibility of up to $10 million including outsourced studies—from the National Institute of Neurological Disorders and Stroke to complete preclinical studies on a new anti-migraine drug candidate.
Scientists from The Scripps Research Institute Florida campus have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output, findings that could aid future drug design.
Scientists from The Scripps Research Institute (TSRI) and the Janssen Pharmaceutical Companies of Johnson & Johnson (Janssen) have found a way to induce antibodies to fight a wide range of influenza subtypes—work that could one day eliminate the need for repeated seasonal flu shots.
Scientists at The Scripps Research Institute have discovered that the human pathogen Staphylococcus aureus develops resistance to the antibiotic arylomycin by “switching on” a previously uncharacterized set of genes, explaining higher antibiotic resistance rates in some bacteria.
Working as part of an international team in the United States and West Africa, a researcher at The Scripps Research Institute has published new findings showing the ancient roots of the deadly Lassa virus, a relative of Ebola virus, and how Lassa virus has changed over time.
A team led by scientists at The Scripps Research Institute has devised an improved method to re-engineer proteins into larger proteins, such as antibodies, to improve their usefulness.
With implications for future drug design, scientists The Scripps Research Institute’s Florida camps have shown an unprecedented mechanism for how a natural antibiotic with antitumor properties incorporates sulfur into its molecular structure, an essential ingredient of its antitumor activity.
A study from scientists at The Scripps Research Institute explores a bacterial enzyme that might be used as a drug candidate to help people quit smoking. The research shows this enzyme can be recreated in lab settings and possesses a number of promising characteristics for drug development.
Scientists from the Florida campus of The Scripps Research Institute have shown how aging cripples the production of new immune cells, decreasing the immune system’s response to vaccines and putting the elderly at risk of infection.
Scientists from the Florida campus of The Scripps Research Institute have made a discovery that brings them closer to a new therapy based on selectively erasing dangerous and tenacious drug-associated memories.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded $1.4 million from the National Institute of Mental Health of the National Institutes of Health (NIH) to explore the development of drug candidates for a wide range of conditions, including circadian rhythm disorders.
Scientists from the Florida campus of The Scripps Research Institute have been awarded nearly $1.5 million from the National Institute of General Medical Sciences to explore the therapeutic potential of a class of proteins that play essential roles in the regulation and maintenance of human health.
The Scripps Research Institute has been awarded two grants from the Bill & Melinda Gates Foundation totaling more than $4.5 million to fund new tools to collect and process high-resolution images of HIV proteins interacting with antibodies with goal to develop a vaccine against HIV/AIDS.
Scientists at The Scripps Research Institute Florida campus have been awarded a pair of grants totaling nearly $2.8 million to develop a new therapeutic agent to reduce latent levels of HIV that hide from the immune system in infected individuals.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered how mutations in a specific autism risk gene alter the basic trajectory of early brain development in animal models.
Researchers from The Scripps Research Institute have received a grant of more than $1.2 million from the National Institute of Environmental Health Sciences’ ViCTER program to augment existing research into how environmental factors trigger such autoimmune diseases.
Scientists from the Florida campus of The Scripps Research Institute have shown that, unlike other antiretroviral therapies, a natural compound called Cortistatin A establishes a near-permanent state of latency and greatly diminishing the HIV virus’ capacity for reactivation.
Scientists from the Florida campus of The Scripps Research Institute have found that a type of genetic material called “microRNA” plays surprisingly different roles in the formation of memory in animal models. In some cases, these RNAs increase memory, while others decrease it.
A new study led by scientists at The Scripps Research Institute identifies new immune molecules that protect against deadly Marburg virus, a relative of Ebola virus. The research provides ingredients needed to develop treatments for future Marburg outbreaks.
A new study led by scientists at The Scripps Research Institute reveals a key part of the Ebola virus life cycle at a higher resolution than ever before. The research sheds light on how Ebola virus assembles—and how researchers might stop the often-fatal infection.
Scientists from the Florida campus of The Scripps Research Institute have been awarded $3.5 million from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health to accelerate development of a new class of anti-diabetic compounds.
Scientists at The Scripps Research Institute have devised a powerful set of chemical methods for exploring the biology of proteins. The techniques are designed to reveal protein interactions with lipids.
Scientists at The Scripps Research Institute have teamed up with several other institutions and pharmaceutical companies, to publish the first 3D structures of a receptor implicated in many diseases of the brain and in normal physiology throughout the body.
New research led by scientists at The Scripps Research Institute, International AIDS Vaccine Initiative and The Rockefeller University shows in mice that an experimental vaccine candidate designed at TSRI can stimulate the immune system activity necessary to stop HIV infection.
Scientists from the Florida campus of The Scripps Research Institute have established conclusively that an activating protein, called “Rhes,” plays a pivotal role in focusing the toxicity of Huntington’s disease.
Chemists at The Scripps Research Institute have invented the first practical, scalable method for synthesizing jiadifenolide, a plant-derived molecule that may have powerful brain-protecting properties.
Scientists from the Florida campus of The Scripps Research Institute have identified a new therapeutic approach that, while still preliminary, could promote the development of new bone-forming cells in patients suffering from bone loss.
A new study from The Scripps Research Institute, Florida campus, integrates neuroscience and psychological research to reveal how sleep suppresses certain nerve cell activity that promotes forgetting, insuring that at least some memories will last.
While it is well-known that weight gain results from an imbalance between what we eat and our energy expenditure, not so obvious is the role the nervous system plays in controlling energy balance. Scientists from the Florida campus of The Scripps Research Institute have shed light on the question.
Scientists from the Florida campus of The Scripps Research Institute have been awarded $2.1 million from the National Institute of Neurological Disorders and Stroke to study a protein that has been closely linked in animal models to Parkinson’s disease and Huntington’s disease.
Scientists from the Florida campus of The Scripps Research Institute have found that a drug candidate with anticancer potential can be activated by one of the body’s natural responses to cellular stress. Once activated, the agent can kill prostate cancer cells.
Scientists at The Scripps Research Institute have found that state-specific odor “blindness” exists in female mice, who cannot sense the odor of male mice when in diestrus, the period of sexual inactivity during the reproductive cycle, pointing to new avenues for studying senses and behavior.
Scientists from The Scripps Research Institute Florida campus have been awarded nearly $2.2 million by the National Institute of Diabetes and Digestive and Kidney Diseases to advance an innovative approach to the treatment of obesity.
Chemists at The Scripps Research Institute have discovered a broad, strikingly inexpensive method for synthesizing “amines,” a class of organic compounds prominent in drugs and other modern products. The new reaction is particularly useful for synthesizing complex amines valuable in pharmaceuticals, but impractical—or impossible—to make with standard methods.
Interferon proteins are normally considered virus-fighters, but scientists at The Scripps Research Institute have found evidence that one of them, interferon beta, has an immune-suppressing effect that can help some viruses establish persistent infections.
Scientists from The Scripps Research Institute, working closely with researchers at the National Institutes of Health, have mapped out the structure of an important protein involved in cellular function and nervous system development.
Scientists at The Scripps Research Institute have discovered that a brain protein has a key role in controlling binge drinking in animal models.
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