An estimated one-quarter of adults in the U.S. have nonalcoholic fatty liver disease (NAFLD), an excess of fat in liver cells that can cause chronic inflammation and liver damage, increasing the risk of liver cancer. Now, UT Southwestern researchers have developed a simple blood test to predict which NAFLD patients are most likely to develop liver cancer.
Four out of five Americans 65 and older want to stay in their homes as they age, according to a recent Associated Press poll. But deciding how long an elderly relative should live alone and when they should move to an environment with more support – such as assisted living or a nursing home – can be difficult.
A collaborative study from UT Southwestern scientists has identified a new function for a protein called TAO2 that appears to be key to inhibiting replication of the influenza virus, which sickens millions of individuals worldwide each year and kills hundreds of thousands. The findings were published in PNAS.
T Southwestern researchers Zhijian “James” Chen, Ph.D., and Sihan Wu, Ph.D., are part of a team that has been awarded a Cancer Grand Challenges grant, a unique award that aims to solve some of cancer’s toughest problems by bringing together global teams with diverse areas of expertise.
Individuals should weigh their own personal health and risk levels in deciding when to receive a second booster of the COVID-19 vaccine, UT Southwestern infectious diseases experts advise.
New research from UT Southwestern suggests that RNA exosomes – the cellular machines that degrade old molecules of RNA – play a key role in the development of B cells, which are critical to the immune system’s ability to protect against infection. The findings, published in Science Immunology, explain why patients with rare mutations in a gene that codes for this machinery are often immunodeficient and could offer new approaches to treat autoimmune diseases.
A student group at UT Southwestern Medical School has been named the 2022 Chapter of the Year by the Texas Medical Association Medical Student Section.
Fifteen scientists in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern received more than $17 million in research funds in the latest round of grants awarded by the Cancer Prevention and Research Institute of Texas (CPRIT). The grants will be used to address scientific questions covering a wide range of cancer types and topics.
Researchers at UT Southwestern have developed a first-of-its-kind ultrasound-guided cancer immunotherapy platform that delivers immune-stimulating agents to cells for the development of systemic anti-tumor immunity. The technology, termed Microbubble-assisted Ultrasound-guided Immunotherapy of Cancer (MUSIC), was described in a study published in Nature Nanotechnology.
A compound synthesized by a team led by UT Southwestern scientists kills a range of hard-to-treat cancer types by targeting a previously unexploited vulnerability, a new study reports. The findings, published in Nature Cancer, could eventually lead to new drugs to fight these cancers, which currently have few effective treatments.
Protein complexes that play a critical role in launching an immune response assemble in droplets that form within the liquid environment in cells much like oil droplets in water, UT Southwestern scientists report in a new study. The findings, published in Molecular Cell, could lead to new interventions to regulate immunity in individuals with overactive or underactive immune responses.
The rapid adoption of telemedicine and increased use of continuous glucose monitoring helped to attenuate the impacts of the COVID-19 pandemic on children with Type 1 diabetes, according to a new study from UT Southwestern researchers.
With summer approaching and temperatures on the rise, it’s important to protect not just your skin but also your eyes from the sun’s rays.
When Vickie Bell-Percival was offered the opportunity to have a nodule on her thyroid treated with a new nonsurgical technique called radiofrequency ablation (RFA), she didn’t hesitate.
A multicenter study performed by a large international consortium that includes UT Southwestern has outlined a set of risk factors and outcomes for patients with autoimmune hepatitis (AIH) that recurs after liver transplantation. The findings, published in the Journal of Hepatology, represent a first step toward better managing and potentially preventing this uncommon condition.
UT Southwestern researchers have discovered a molecular pathway that allows cells to sense when their lipid supplies become depleted, prompting a flurry of activity that prevents starvation. The findings, reported in Nature, might someday lead to new ways to combat metabolic disorders and a variety of other health conditions.
For three decades, scientists have debated the underlying cause of Gulf War illness (GWI), a collection of unexplained and chronic symptoms affecting veterans of the Persian Gulf War. Now researchers led by Robert Haley, M.D., Professor of Internal Medicine and Director of the Division of Epidemiology at UT Southwestern, have solved the mystery, showing through a detailed genetic study that the nerve gas sarin was largely responsible for the syndrome.
A new study in mice led by neuroscientists at UT Southwestern’s Peter O’Donnell Jr. Brain Institute shows that it’s not just calories that count.
Scar-like cells that make up a sizable portion of malignant pancreatic tumors and shield these cancers from immune attack are derived from mesothelial cells that line tissues and organs, a new study led by UT Southwestern researchers suggests. The findings, published in Cancer Cell, could offer a new strategy to fight pancreatic cancer, a deadly disease for which no truly effective treatments exist.
The findings, published in The Laryngoscope, show that only 1 in 7 subsequently needed surgery for injuries that weren’t resolved with vocal therapy and other conservative management. Researchers determined which vocal injuries were most common by sex, age, training, and professional/amateur status, and what kinds of treatment these patients subsequently required.
The National Academy of Sciences (NAS) today elected UT Southwestern scientist Jonathan Cohen, Ph.D., into its membership, one of the highest honors for American scientists. Dr. Cohen, Professor of Internal Medicine in the Center for Human Nutrition and the Eugene McDermott Center for Human Growth and Development at UT Southwestern, was elected by his peers in recognition of distinguished and continuing achievements in original research. His research centers on identifying genes that play major roles in the metabolism of cholesterol and triglycerides and elucidating the biological roles of their protein products.
For years, women recovering from cesarean section (C-section) deliveries have been given devices that let them, with a button, control the flow of opioid painkillers into their IV line. But as researchers and policymakers push to curb the use of opioids, clinicians are developing new strategies for treating pain after C-sections.
UT Southwestern Medical Center is ranked as the top health care employer for diversity in the U.S. and among the top 20 across all industries, according to America’s Best Employers for Diversity 2022 list compiled by Forbes and Statista. UT Southwestern is the only health care institution listed among the top 20 employers nationally.
Women who were pregnant during the recent Omicron surge were diagnosed with COVID-19 at a much higher rate than during previous phases of the pandemic, but were less likely to develop severe illness, a study by UT Southwestern and Parkland Health scientists found. The research, reported in JAMA, is the first published evidence documenting how the boom in COVID-19 cases late last year and early this year impacted the health of pregnant women.
UT Southwestern Medical Center is among the Top Producing Institutions of 2021-2022 Fulbright Students in the U.S., and one of the top producers of U.S. Fulbright students among 4-year, special-focus institutions.
The National Institutes of Health (NIH) and the National Institute on Aging recently approved funding for a 2022 study by the Institute for Exercise and Environmental Medicine (IEEM), where a research team will look into how body weight – even extra weight gain like the kind recently resulting from the COVID-19 pandemic – may adversely affect breathing in seniors.
Imaging at near-atomic resolution of a key immune protein commonly known as STING has revealed a previously unrecognized binding site that appears to be pivotal for launching immune attacks, UT Southwestern scientists report in a new study. The findings, published in Nature, could lead to new ways of manipulating STING to prompt stronger immune responses or stem its action in autoimmune diseases.
Cellphone “selfies” distort facial features, an effect that may be driving an uptick in requests for plastic surgery, UT Southwestern researchers show in a new study. The findings, reported in Plastic and Reconstructive Surgery, highlight an unexpected consequence of social media and the need for plastic surgeons to discuss this phenomenon with their patients.
UTSW scientists identify key molecule produced by male parasitic worms that affects sexual maturity in females and leads to schistosomiasis
Babies and toddlers who need a tracheostomy – a tube surgically inserted into their windpipe to help relieve breathing problems – are at a high risk of accumulating fluid behind their eardrum when on a ventilator. That’s the conclusion of a new study, published in the International Journal of Pediatric Otorhinolaryngology, by UT Southwestern head and neck surgeons. This buildup of fluid, called a middle ear effusion, can put them at risk for ear infections, hearing loss, and delays in speech and language development.
UT Southwestern researchers have identified a four-protein complex that appears to play a key role in generating ribosomes – organelles that serve as protein factories for cells – as well as a surprising part in neurodevelopmental disorders. These findings, published in Cell Reports, could lead to new ways to manipulate ribosome production, which could impact a variety of conditions that affect human health.
The dominant form of heart failure worldwide appears to be caused by a strong, bidirectional interaction between the body’s response to metabolic stress and the immune system, according to a review article written by UT Southwestern researchers and colleagues. The article, published in Nature Cardiovascular Research, argues for more research into this root cause to develop truly effective treatments.
More than 200 UT Southwestern medical students matched to more than 80 programs across the nation, including Harvard, Yale, and Johns Hopkins, as well as a dozen medical programs across Texas.
The PGA of America and Omni Hotels & Resorts today announced a new six-year partnership with UT Southwestern Medical Center, naming the hospital as the “Official Healthcare Partner of PGA Frisco.” The relationship will begin in 2023, to coincide with the official opening of PGA Frisco and Omni PGA Frisco Resort.
Cognitive decline is the biggest factor in determining how long patients with Alzheimer’s disease will live after being diagnosed, according to a new study from researchers at UT Southwestern. The findings, published in the Journal of Alzheimer’s Disease, are a first step that could help health care providers provide reliable prediction and planning assistance for patients with Alzheimer’s disease and their families.
To meet growing demand for primary and preventive health care in Fort Worth, Tarrant and surrounding counties, UT Southwestern Medical Center has launched a new primary care clinic in the UT Southwestern Monty and Tex Moncrief Medical Center at Fort Worth.
A single protein can reverse the developmental clock on adult brain cells called astrocytes, morphing them into stem-like cells that produce neurons and other cell types, UT Southwestern researchers report in a PNAS study. The findings might someday lead to a way to regenerate brain tissue after disease or injury.
Diagnosing heart attacks after heart surgery remains difficult due to shortcomings of current diagnostic tools when applied to postoperative patients, including the electrocardiogram and blood tests to detect levels of cardiac troponins, according to an editorial in the New England Journal of Medicine (NEJM) written by two UT Southwestern faculty members.
UT Southwestern Medical Center is pleased to announce a $100 million gift from the O’Donnell Foundation to endow and support its new School of Public Health. This investment is the largest gift to a School of Public Health at a public university in the U.S. and matches the third largest gift supporting any School of Public Health.
In humans, virtually every cell stores fat. However, patients with a rare condition called congenital lipodystrophy, which is often diagnosed in childhood, cannot properly store fat, which accumulates in the body’s organs and increases the risk of early death from heart or liver disease. In 2001, a transmembrane protein called seipin was identified as a molecule essential for proper fat storage, although its mechanism has remained unknown.
COVID-19 patients who receive a palliative care consultation are 5.6 times more likely to receive comfort care at the end of life and are just as likely to receive CPR if needed as those who did not receive a consultation, according to a UT Southwestern study.
Patients with both a high lipoprotein(a) and high coronary artery calcium score (CAC) face a more than 20% risk of heart attack or stroke over the following 10 years, according to findings from a multicenter study led by preventive cardiologists at UT Southwestern Medical Center.
Blood pressure rose moderately during the early months of the pandemic, according to a UT Southwestern study of patients who monitored themselves at home.
UT Southwestern Medical Center has completed a five-year, $1 billion campaign to fuel its commitment to advance brain research and clinical care at its Peter O’Donnell Jr. Brain Institute, making it one of the largest brain-focused investments at a U.S. academic medical center.
Changes in habits during the pandemic can lead to unexpected health issues with feet and ankles. Orthopedic surgeon Kshitij Manchanda, M.D. at UT Southwestern Orthopaedic Surgery and Sports Medicine has seen an increase in both reported injuries and chronic problems.
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UT Southwestern Medical Center is one of the 10 best large employers in the United States and among the top 5 health care employers, according to the America’s Best Employers 2022 list compiled by Forbes and Statista.
Stroke patients on long-term blood thinners who were given the clot-busting drug alteplase enjoyed better recoveries than those who did not receive the drug and had no increased risk of bleeding, a new study led by UTSW researchers shows. The results run counter to the common practice of withholding the clot-busting drug to these patients due to concerns over complications from bleeding.
Mechanical hearts spur some regeneration in dormant parts of failing hearts, according to a UT Southwestern pilot study that shows promise for developing regenerative heart therapies.
Samuel Achilefu, Ph.D., nationally recognized for expertise in molecular imaging and its application in treating human diseases, has been selected inaugural Chair to launch a new Department of Biomedical Engineering (BME) at UT Southwestern Medical Center. He begins his new responsibilities Feb. 1.
A new approach that targets the cellular machinery that viruses need to reproduce – rather than the virus itself – appears to stem replication of a common childhood pathogen known as respiratory syncytial virus (RSV), UT Southwestern researchers report in a new study. The findings, published in Scientific Reports, could offer a novel strategy to fight this virus and others, including SARS-CoV-2, the virus responsible for the ongoing COVID-19 pandemic.
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