The study published today in the journal Cancer Cell suggests that leukemia cells change in unique ways in response to the chemotherapy, allowing them to masquerade for a short time so they are able to start disease regeneration.
A new analysis of human hair taken from the remains of one of the members of the Franklin expedition, is providing further evidence that lead poisoning was just one of many different factors contributing to the deaths of the crew, and not the primary cause, casting new doubt on the theory that has been the subject of debate amongst scientists and historians for decades.
A group of McMaster researchers has designed and built specialized hardware for their research using an in-house 3D printer. The new lab instrument is capable of collecting massive amounts of data that will help these researchers in their quest to discover new antibiotics.
Now scientists of the Population Health Research Institute (PHRI) of McMaster University and Hamilton Health Sciences are using research from several large global studies to develop an updated, international approach of identifying a healthy diet.
Patients with cardiovascular disease who develop major internal bleeding are much more likely to be diagnosed with cancer, a large international clinical trial has found. Patients with gastrointestinal (GI) bleeding are 18 times more likely to be diagnosed with GI tract cancer, and those who major genitourinary (GU) tract bleeding are 80-fold more likely to be diagnosed with GU cancer, than patients without internal GI or GU bleeding, respectively.
New research shows that for the vast majority of individuals, sodium consumption does not increase health risks except for those who eat more than five grams a day, the equivalent of 2.5 teaspoons of salt. The research, published in The Lancet, is by scientists of the Population Health Research Institute (PHRI) of McMaster University and Hamilton Health Sciences, along with their research colleagues from 21 countries.
Just two weeks without much activity can have a dramatic impact on health from which it is difficult to recover, according to researchers who studied overweight older adults at risk of developing Type 2 diabetes.
McMaster University researchers have developed a new theory on Huntington’s disease which is being welcomed for showing promise to open new avenues of drug development for the condition.
In what is believed to be the first major science gathering on a First Nation in Canada, researchers from across the country will come together June 3 – 6 for the inaugural meeting of Global Water Futures (GWF) on the Six Nations of the Grand River and at McMaster University to discuss critically important issues related to Canada’s fresh water resources.
People with mild asthma are often prescribed a daily treatment regimen, but up to 80 per cent do not follow the routine, using inhalers only when they have an asthma attack. Now the researchers have found an as-needed combined-drug inhaler is a viable treatment option.
Researchers have uncovered important genomic data from the remains of an ancient giant ground sloth, or Mylodon darwinii, the emblematic creature named after Charles Darwin, whose discovery of fossilized remains in South America is considered to be one of his significant scientific achievements.
Extensive data analyses show that supplemental oxygen, when given liberally to acutely ill adults, increases the risk of death without improving other health outcomes.
The research team analyzed muscle biopsies of young adults with and without Type 1 diabetes who exceed Diabetes Canada's recommended weekly levels for physical activity. The researchers found structural and functional changes in the power generation parts of the cell, or mitochondria, of those with diabetes. Not only were the mitochondria less capable of producing energy for the muscle, they were also releasing high amounts of toxic reactive oxygen species, related to cell damage.
New research from a team of scientists at McMaster University suggests that brief exercise breaks during lectures can help university students focus their attention, retain information and improve overall learning.
McMaster researchers have developed a test to bring certainty to the delicate but critical question of whether meat and other foods are safe to eat or need to be thrown out.
The study enrolled 1,754 patients in 19 countries, 51 percent of whom were male, with an average age of 70 years. After an average follow-up of 16 months, 11 percent of patients treated with dabigatran experienced a MINS-related event, compared with 15 percent of patients who received a placebo. This translates to a 28 percent reduction in risk for patients receiving dabigatran.
The researchers used genetically engineered models and computer algorithms to study a human genome, which allowed them to pinpoint the single gene in question.
An international team of researchers has produced one of the most comprehensive evolutionary pictures to date by looking at one of the world's most iconic animal families - namely elephants, and their relatives mammoths and mastodons-spanning millions of years.
The study included completion of an online survey by 27 physicians, who reported working in 15 of 26 provincial correctional facilities for adults in Ontario. This included 10 of the 13 facilities with a population of more than 200. The study identified that about half of the physicians prescribed methadone and half prescribed buprenorphine/naloxone to treat opioid dependence.
The debate is over. Dietary protein supplements significantly improve muscle strength and size when taken by healthy adults who lift weights, a determination reached by McMaster scientists who analyzed dozens of research studies.
Two McMaster University biochemists are working to explain the mysteries of DNA through a novel new public course, called DNA Decoded, which is available to everyone.
Pharmaceuticals and other man-made contaminants are forcing fish that live downstream from a typical sewage treatment plant to work at least 30 per cent harder just to survive, McMaster researchers have found.
New data analysis suggests that people born at the time of the 1957 H2N2 or Asian Flu pandemic were at a higher risk of dying during the 2009 H1N1 Swine Flu pandemic as well as the resurgent H1N1 outbreak in 2013-2014. And it is not the first time this has happened.
Scientists have sequenced the complete genome of an ancient strain of Hepatitis B, shedding new light on a pathogen that today kills nearly one million people every year. The findings, based on data extracted from the mummified remains of a small child buried in Naples, Italy, confirm the idea that HBV has existed in humans for centuries.
The researchers looked at 37 genes that are well established as modulating the body mass in 75,230 adults with European ancestry and found the nine with the snowball effect.
There is a more than 50 per cent reduction in the occurrence of headaches with the atraumatic needles, and also more than a 50 per cent reduction in patient readmissions and return to emergency rooms for narcotics or blood patches.
A team of researchers from Environment Canada and Climate Change Canada and McMaster University have found that fish living downstream from a wastewater treatment plant showed changes to their normal behaviour—ones that made them vulnerable to predators—when exposed to elevated levels of antidepressant drugs in the water.
The study utilized data from 74 mother-infant pairs in the McMaster pilot cohort called Baby & Mi. Participants came from low-risk populations in Hamilton and Burlington, Ontario. The gut bacteria development of the infants was tested at four points over the first 12 weeks of life, including at three days, 10 days, six weeks and 12 weeks.
The study, published in the medical journal Osteoarthritis and Cartilage, found that monocytes, the white blood cells necessary to regulate immune responses, were more activated and pro-inflammatory in women with osteoarthritis, and that elevated inflammation and body mass index were associated with this increased activation.
The health advantages of high-intensity exercise are widely known but new research from McMaster University points to another major benefit: better memory. The findings could have implications for an aging population which is grappling with the growing problem of catastrophic diseases such as dementia and Alzheimer’s.
Using data from more than 2,300 children from across Canada participating in the CHILD Study, the researchers evaluated the presence of AD and allergic sensitization at age one. When the children were three years of age, the researchers performed a clinical assessment to determine the presence of asthma, allergic rhinitis, food allergy and AD. The combined effect of AD and allergic sensitization was found to be greater than the sum of their individual effects, both on the risk of asthma and on reported food allergy.
McMaster University neuroscientists studying sports-related head injuries have found that it takes less than a full concussion to cause memory loss, possibly because even mild trauma can interrupt the production of new neurons in a region of the brain responsible for memory. Though such losses are temporary, the findings raise questions about the long-term effects of repeated injuries and the academic performance of student athletes.
Human teeth hold vital information about Vitamin D deficiency, a serious but often hidden condition that can now be identified by a simple dental X-ray, McMaster anthropologists Lori D’Ortenzio and Megan Brickley have found.
The multidisciplinary Michael G. DeGroote Centre for Medicinal Cannabis Research (CMCR) will focus on conducting research, sharing evidence-based information and creating a network of professionals interested in further understanding medicinal cannabis.
The research team compared samples of vaginal microbiota of both women who were involved in sex work and those who were not sex workers in Nairobi, Kenya.
Researchers at McMaster University have developed a new drug screening technique that could lead to the rapid and accurate identification of fentanyl, as well as a vast number of other drugs of abuse, which up until now have been difficult to detect by traditional urine tests.
Killing cancer cells indirectly by powering up fat cells in the bone marrow could help acute myeloid leukemia patients, according to a study from McMaster University's Stem Cell and Cancer Research Institute and published in Nature Cell Biology.
The study utilized the McMaster Extremely Low Birth Weight (ELBW) Cohort, which includes a group of 179 extremely low birth weight survivors and 145 normal birth weight controls born between 1977 and 1982, which has 40 years' worth of data. The study showed that although these preemies were not necessarily exposed to a larger number of risk factors compared to their normal birth weight counterparts, these stresses appeared to have a greater impact on their mental health as adults. The study utilized the McMaster Extremely Low Birth Weight (ELBW) Cohort, which includes a group of 179 extremely low birth weight survivors and 145 normal birth weight controls born between 1977 and 1982, which has 40 years' worth of data.
The Prospective Urban Rural Epidemiology (PURE) study, led by the Population Health Research Institute of McMaster University and Hamilton Health Sciences, shows any activity is good for people to meet the current guideline of 30 minutes of activity a day, or 150 minutes a week to raise the heart rate.
Antidepressant medications, most commonly prescribed to reduce depression and anxiety, increase the risk of death, according to new findings by a McMaster-led team of researchers.
A new $2.7 million Canadian study is aiming to narrow the gap between the care that frail elderly Canadians want and the care that they receive by evaluating ways to improve care planning conversations between patients, families and health professionals.
Research with more than 135,000 people across five continents has shown that a diet which includes a moderate intake of fat and fruits and vegetables, and avoidance of high carbohydrates, is associated with lower risk of death.
A major international study has found that the combination of two drugs – rivaroxaban and aspirin -- is superior to aspirin alone in preventing further heart complications in people with vascular disease.
Research was based on data from the START Birth Cohort study, which includes more than 1,000 women in their second trimester of pregnancy.
The researchers set out to find which genes can regulate the cells that initiate brain metastases - what are the genes that are sending the signal to leave the lung tumour, go into the blood stream, invade the blood-brain barrier and form a tumour in the brain.
Researchers have identified two new biological markers of cystic fibrosis (CF), a genetic disease which affects children and young adults, leaving them with lifelong health complications including digestive problems and persistent lung infections. The findings, published in the journal ACS Central Science, shed new light on the underlying mechanisms of CF and could lead to improved prognosis and better therapies for a disease which is quite variable, affecting different children in different ways, say researchers.
Whey protein supplements aren’t just for gym buffs according to new research from McMaster University. When taken on a regular basis, a combination of these and other ingredients in a ready-to-drink formula have been found to greatly improve the physical strength of a growing cohort: senior citizens.
New biological information gleaned from the red vizcacha rat, a native species of Argentina, demonstrates how genomes can rapidly change in size. Researchers from McMaster University set out to study this particular species because its genome, or its complete set of DNA, is the largest of all mammals, and appears to have increased in size very rapidly.
A definitive guide to the findings from cutting-edge clinical research on addiction to front-line clinicians is found in a new book, Integrating Psychological and Pharmacological Treatments for Addictive Disorders published by Routledge.
Researchers worked backwards, employing a series of drugs used in the clinic to understand a new way that cancer stem cells can be killed.
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