A study by UT Southwestern researchers finds that changing the biochemistry of parts of brain cells abolished the formation of amyloid beta plaques in a mouse model of Alzheimer’s disease. The finding, published in eLife, might eventually lead to treatments that prevent the memory-robbing condition in humans.
UT Southwestern researchers have identified a new mechanism by which stress causes cells to stop dividing.
Samuel Achilefu, Ph.D., the incoming Inaugural Chair of UT Southwestern Medical Center’s new Department of Biomedical Engineering, is among 100 members elected to the National Academy of Medicine (NAM) this year.
A genome engineering technique developed at UT Southwestern Medical Center helped make the institution a research partner in a new $185 million National Institutes of Health (NIH) initiative to build on findings of the Human Genome Project.
How cancers metastasize remains poorly understood. The process begins when cancer cells break off from a tumor and invade blood and lymphatic vessels, the body’s alleyways. But studying invasion - typically a microscopic process - is challenging.
Oxygen-deprived newborns who undergo cooling therapy to protect their brains are at an elevated risk of seizures and brain damage during the rewarming period, which could be a precursor of disability or death, a new study by a team of researchers led by a UT Southwestern pediatrician suggests. The finding, published online in JAMA Neurology, could lead to better ways to protect these vulnerable patients during an often overlooked yet critical period of cooling – or hypothermia – therapy.
Peter O’Donnell Jr., whose vision, legendary generosity, and cherished friendship graced UT Southwestern Medical Center for many decades, passed away Oct. 10 at the age of 97.
A team of researchers at UT Southwestern Medical Center’s Touchstone Diabetes Center have successfully used CRISPR gene editing to turn fat cells normally used for storage into energy-burning cells.
Specialized cells that conduct electricity to keep the heart beating have a previously unrecognized ability to regenerate in the days after birth, a new study in mice by UT Southwestern researchers suggests. The finding, published online in the Journal of Clinical Investigation, could eventually lead to treatments for heart rhythm disorders that avoid the need for invasive pacemakers or drugs by instead encouraging the heart to heal itself.
Lu Sun, Ph.D., Assistant Professor of Molecular Biology at UT Southwestern, has been awarded $1.5 million from the National Institutes of Health (NIH) to study interactions between neurons and glial cells in the brain, which could provide insight into the causes of neurological disorders.
Jian Zhou, Ph.D., Assistant Professor in UT Southwestern’s Lyda Hill Department of Bioinformatics, has been awarded $1.5 million from the National Institutes of Health (NIH) to use artificial intelligence to investigate the three-dimensional structure of DNA and its impact on health.
Lorena Saelices Gomez, Ph.D., Assistant Professor of Biophysics and in the Center for Alzheimer’s and Neurodegenerative Diseases at UT Southwestern, has been awarded $1.5 million from the National Institutes of Health (NIH) to determine the structure of amyloids, key proteins that have been tied to diseases including Alzheimer’s and ATTR amyloidosis.
A UT Southwestern research team has received the National Institutes of Health’s prestigious Transformative Research Award to further their study of zebra finches to investigate the genetic basis of vocal imitation abilities.
An international panel of experts from four renowned diabetes research centers, including UT Southwestern Medical Center, has reviewed current literature and is recommending a pivotal change in treatment of Type 2 diabetes to focus on obesity first and glucose control second.
Unvaccinated pregnant women are increasingly being hospitalized with COVID-19 during a nationwide surge of the Delta variant, according to research from UT Southwestern Medical Center.
UT Southwestern stem cell scientists find that stringent lineage tracing is crucial for studies of nerve cell regeneration. Their results, which are published in Cell, show that this tracing is far from routine in the field and suggest that earlier studies reporting “striking” regeneration results must be reexamined.
Researchers and data scientists at UT Southwestern Medical Center and MD Anderson Cancer Center have developed an artificial intelligence technique that can identify which cell surface peptides produced by cancer cells called neoantigens are recognized by the immune system.
Two UT Southwestern Medical Center researchers – a biochemist and a molecular biologist – are among 33 distinguished scientists nationwide named Howard Hughes Medical Institute (HHMI) Investigators.
A study led by UT Southwestern dermatologists suggests that a common inflammatory skin condition may stem from poorly regulated sex hormones. The finding, published this week in PNAS, could offer an unexpected new target to fight this condition.
Immunologists and geneticists at UT Southwestern Medical Center have discovered how vitamin A enters immune cells in the intestines – findings that could offer insight to treat digestive diseases and perhaps help improve the efficacy of some vaccines.
UT Southwestern Medical Center will lead the nation’s first study of suicide prevention for LGBTQ+ young adults – a group at higher risk for depression and suicide.
Adenomyosis – an abnormal tissue growth into the muscular wall of the uterus that causes painful cramps and heavy or prolonged menstrual bleeding – is more common than generally appreciated, a review of the literature by gynecologists at UT Southwestern Medical Center revealed.
A new study by UT Southwestern scientists indicates that an enzyme called protein phosphatase 2 (PP2A) appears to be a major driver of preeclampsia, a dangerous pregnancy complication characterized by the development of high blood pressure and excess protein in the urine. The finding, published in Circulation Research, could lead to new treatments for preeclampsia other than premature delivery, which is often the only option.
The National Cancer Institute has renewed the Harold C. Simmons Comprehensive Cancer Center’s comprehensive designation, reaffirming its place among the country’s elite cancer institutes.
UT Southwestern Medical Center was recognized as the top health care employer in Texas, one of the top 10 employers across all industries in the state, and among the nation’s Best-in-State employers nationally by Forbes/Statista.
UT Southwestern Medical Center is one of just 15 surgical centers in the world using next-generation augmented reality (AR) in the operating room for shoulder arthroplasty. Shoulder specialist Michael Khazzam M.D., Associate Professor of Orthopaedic Surgery, became the first orthopedic surgeon in Texas to use the Food and Drug Administration-approved technique while operating to restore shoulder function.
In a move that will increase access and efficiency of clinical trials for patients with sickle cell disease, UT Southwestern has become a founding member of the new Sickle Cell Disease Clinical Trials Network (SCD CTN) to bring treatments and curative options to people suffering from this potentially life-shortening red blood-cell disorder.
DALLAS – Aug. 23, 2021 – A first-in-kind kidney cancer drug developed from laboratory and translational studies conducted at UT Southwestern Medical Center received approval from the Food and Drug Administration, providing a new treatment for patients with familial kidney cancer.
DALLAS – Aug. 20, 2021 – Artificial intelligence, along with a $71-million expansion of Radiation Oncology services, is allowing UT Southwestern Medical Center cancer physicians to pioneer a new PULSAR radiation-therapy strategy that improves tumor control compared with traditional daily therapy.
DALLAS – Aug. 20, 2021 – A stress signal received by the heart from fat could help protect against cardiac damage induced by obesity, a new study led by UT Southwestern researchers suggests. The finding, published online in Cell Metabolism, could help explain the “obesity paradox,” a phenomenon in which obese individuals have better short- and medium-term cardiovascular disease prognoses compared with those who are lean, but with ultimately worse long-term outcomes.
Moderately ill patients hospitalized with COVID-19 have better chances of survival if treated with therapeutic-dose anticoagulation, according to an international study involving 121 sites, including UT Southwestern Medical Center.
DALLAS – Aug. 19, 2021 – A gene called Npas4, already known to play a key role in balancing excitatory and inhibitory inputs in brain cells, appears to also be a master timekeeper for the brain’s circadian clock, new research led by UT Southwestern scientists suggests. The finding, published online today in Neuron, broadens understanding of the circadian clock’s molecular mechanisms, which could eventually lead to new treatments for managing challenges such as jet lag, shift work, and sleep disorders.
A two-arm molecule can effectively deplete cancer-protecting cells inside tumors, allowing the immune system to fight off tumors without becoming overactive. The finding, published online in Science Translational Medicine, could leaA two-arm molecule can effectively deplete cancer-protecting cells inside tumors, allowing the immune system to fight off tumors without becoming overactive. The finding, published online in Science Translational Medicine, could lead to new types of cancer immunotherapies.d to new types of cancer immunotherapies.
Using a virus to purposely mutate genes that produce cancer-driving proteins could shed light on the resistance that inevitably develops to cancer drugs that target them, a new study led by UT Southwestern scientists suggests. The findings, published online in Cancer Research, could help researchers develop drugs that circumvent resistance, validate new drug targets, or better understand the interaction between drugs and their target proteins.
Using artificial intelligence (AI), researchers from UT Southwestern have developed a way to accurately predict which skin cancers are highly metastatic. The findings, published as the July cover article of Cell Systems, show the potential for AI-based tools to revolutionize pathology for cancer and a variety of other diseases.
DALLAS – August 5, 2021 – Significant disparities exist in diagnosing and treating headaches by race, socioeconomic level, and insurance status, despite the fact that headaches afflict nearly all racial and ethnic groups at the same rate, according to research led by UT Southwestern Medical Center faculty.
DALLAS – August 4, 2021 – Researchers at UT Southwestern announced successful results of a clinical trial for a commonly prescribed weight-loss drug called liraglutide. In adults who are overweight or have obesity combined with high cardiovascular risk, once-daily liraglutide combined with lifestyle interventions significantly lowered two types of fat that have been associated with risk to heart health: visceral fat and ectopic fat.
DALLAS – July 30, 2021 – UT Southwestern faculty have discovered what appears to be an Achilles’ heel in ovarian cancers, as well as new biomarkers that could point to which patients are the best candidates for possible new treatments.
DALLAS – July 29, 2021 – Forbes and Statista have selected UT Southwestern among the top 40 Best Employers for Women 2021.
DALLAS – July 28, 2021 – The body’s ability to prevent food poisoning by producing a natural antimicrobial compound increases during the day, when exposure to noxious bacteria is most likely, a new study by UT Southwestern scientists suggests. The findings, published online in Cell, could eventually lead to timed therapies and vaccination regimens designed to maximize this immune response.
UT Southwesternonce again is ranked the No. 1 hospital in Dallas-Fort Worth – the nation’s fourth-largest metro area – among 132 regional hospitals and second in Texas among 566 hospitals for the fifth consecutive year. The recognition comes several months after UT Southwestern completed expansion of its William P. Clements Jr. University Hospital.
UT Southwestern researchers report the first structural confirmation that endogenous – or self-made – molecules can set off innate immunity in mammals via a pair of immune cell proteins called the TLR4−MD-2 receptor complex. The work has wide-ranging implications for finding ways to treat and possibly prevent autoimmune diseases such as multiple sclerosis and antiphospholipid syndrome.
UT Southwestern researchers have identified an immune protein tied to the rare neurodegenerative condition known as Niemann-Pick disease type C. The finding, made in mouse models and published online in Nature, could offer a powerful new therapeutic target for Niemann-Pick disease type C, a condition that was identified more than a century ago but still lacks effective treatments.
Jere Mitchell, M.D., former director of the Harry S. Moss Heart Center at UT Southwestern Medical Center and an internationally recognized exercise physiologist whose seminal findings on maximal oxygen uptake changed conventional medical practice on bed rest and laid the foundation for central command physiology, died July 17. He was 92.
Using artificial intelligence, UT Southwestern scientists have identified thousands of genetic mutations likely to affect the immune system in mice. The work is part of one Nobel laureate’s quest to find virtually all such variations in mammals.
DALLAS – June 30, 2021 – A relative decline in wealth during midlife increases the likelihood of a cardiac event or heart disease after age 65 while an increase in wealth between ages 50 and 64 is associated with lower cardiovascular risk, according to a new study in JAMA Cardiology.
What if a microscope allowed us to explore the 3D microcosm of blood vessels, nerves, and cancer cells instantaneously in virtual reality? What if it could provide views from multiple directions in real time without physically moving the specimen and worked up to 100 times faster than current technology?
The University of Texas at Arlington (UTA), University of Texas Health Science Center at Houston (UTHealth), and the University of Texas Southwestern Medical Center (UTSW) are pleased to announce the formation of the Texas Health Informatics Alliance (THIA) and plans for its first Texas Health Informatics Alliance Conference, to be held virtually on Sept. 9.
DALLAS – June 28, 2021 – Lowering iron content in fat cells prevented mice fed a high-fat diet from gaining excess weight and developing associated health problems by limiting the amount of lipids absorbed by the intestines, UT Southwestern scientists report in a new study. The findings, published online in Cell Metabolism, could eventually lead to new strategies to protect people against obesity and related diseases.
A new approach using precisely targeted, high-dose radiation to treat invasive kidney cancer proves safe, based on a clinical trial by the UT Southwestern Harold C. Simmons Comprehensive Cancer Center’s kidney cancer program. The study, published in the International Journal of Radiation Oncology*Biology*Physics, could offer new hope for patients with a historically dismal condition.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right
