Newswise — Bethesda, MD (May 4, 2021) – The May issue of The American Journal of Gastroenterology includes newly issued updates to ACG Clinical Guidelines on Upper Gastrointestinal and Ulcer Bleeding and Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury. In addition to the guidelines, this issue features clinical research on esophageal cancer, obesity, telemedicine, celiac disease, Crohn’s disease, and more.

The three articles highlighted below include the two updated guidelines and an additional review of the role of small intestinal bacterial overgrowth in functional dyspepsia. Access to any articles from this issue, or past issues, is available upon request. The College is also able to connect members of the press with study authors or outside experts who can comment on the articles.

ACG Clinical Guideline: Upper GI and Ulcer Bleeding
Laine, et al.
In new clinical guidelines from ACG on the management of upper GI and ulcer bleeding, Loren A. Laine, MD, FACG and colleagues addressed predefined clinical questions such as risk stratification, red blood cell transfusion, and pre-endoscopic medical therapy to develop 16 evidence-based recommendations.

ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
Chalasani, et al.
The authors of this updated ACG guideline outline a diagnostic approach to suspected drug-induced liver injury, including when to consider liver biopsy to supplement the work-up, provide important information regarding disease severity, and help exclude competing causes of liver injury. “Characterizing the injury by latency, pattern of injury (e.g., R-value), mortality risk (Hy’s law) and outcome (resolution vs. chronic) is critical in evaluating and managing DILI in clinical practice,” said the authors.

Small Intestinal Bacterial Overgrowth in Functional Dyspepsia: A Systematic Review and Meta-Analysis
Gurusamy, et al.
In this systematic review and meta-analyses of functional dyspepsia and small intestinal bacterial overgrowth, using breath tests as the diagnostic modality, the prevalence of SIBO is significantly increased in patients with FD, as compared to healthy controls and warrants further investigation.

About the American College of Gastroenterology

Founded in 1932, the American College of Gastroenterology (ACG) is an organization with an international membership of over 16,000 individuals from 86 countries. The College’s vision is to be the preeminent professional organization that champions the prevention, diagnosis, and treatment of digestive disorders, serving as a beacon to guide the delivery of the highest quality, compassionate, and evidence-based patient care. The mission of the College is to enhance the ability of our members to provide world class care to patients with digestive disorders and advance the profession through excellence and innovation based upon the pillars of Patient Care, Education, Scientific Investigation, Advocacy and Practice Management.