METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism

Newswise — Deng and colleagues identify METTL16, an m6A writer, as a strong dependency in AML. METTL16 exerts its tumor-promoting role by altering the abundance of m6A-regulated proteins, BCAT1 and BCAT2, and rewiring BCAA metabolism in AML.