PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes

Efficient maturation of in vitro-generated cells remains a challenge and the underlying mechanisms are poorly understood. Here Wickramasinghe and colleagues show that PPAR signaling acts in an isoform-specific manner to enhance metabolic and electrophysiological maturation of pluripotent stem-cell-derived cardiomyocytes.