Newswise — In the May 2019 issue, Toxicological Sciences features papers on CRISPR screening and acetaldehyde tolerance; systems toxicology for predicting renal toxicity; polycyclic aromatic hydrocarbons (PAHs) and endocrine effects on testicular gap junctions; and vincristine-induced atresia in ovarian follicles. There also are open access papers on intercellular communication in acetaminophen-induced pericentral necrosis and the evaluation of genes involved in non-genotoxic carcinogenesis.
Highlights of Toxicological Sciences Volume 169, Issue 1 include:
- Editor’s Highlight: Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde
- Editor’s Highlight: A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro
- Editor’s Highlight: Polycyclic Aromatic Hydrocarbons and Endocrine Disruption: Role of Testicular Gap Junctional Intercellular Communication and Connexins
- Editor’s Highlight: Vincristine Chemotherapy Induces Atresia of Growing Ovarian Follicles in Mice
- Open Access: Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange
- Open Access: Expression Characteristics of Genes Hypermethylated and Downregulated in Rat Liver Specific to Nongenotoxic Hepatocarcinogens
Toxicological Sciences is the official journal of the Society of Toxicology (SOT), a professional and scholarly organization of more than 8,000 scientists from academic institutions, government, and industry representing the great variety of individuals who practice toxicology in the United States and abroad.
Journal Link: Toxicological Sciences, Volume 169 Issue 1, May 2019